Anticholinesterase Activity of<i>Astragalus gombiformis</i>Extracts

Teyeb, Hassen; Mabrouk, H.; Neffati, Mohamed; Najjar, Mohamed Fadhel

doi:10.1080/22311866.2011.10719103

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…The administration of A. kahiricus extract (25 or 50 mg/kg) 30 minutes before the administration of ethanol markedly decreased the activity of AChE in a dose-dependent manner compared to that in both the control and Eth groups, revealing that A. kahiricus extracts have anticholinesterase activity. Notably, A. gombiformis extracts inhibit AChE activity (15).…”

Section: Discussionmentioning

confidence: 99%

“…Many Astragalus species have been used in traditional Chinese medicine as approved drugs for many years (9,10). Different Astragalus species have been involved in many studies as neuroprotective agents, such as extracts of Astragalus mongholicus, Astragalus hamosus, and Astragalus gombiformis (11)(12)(13)(14)(15). In addition, the active constituent isolated from Astragalus membranaceus, astragaloside (IV) can prevent Aβ 1-42 neurotoxicity in cell lines (16).…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice

Abdelaziz

Helmy

Mohamed

et al. 2019

J Herbmed Pharmacol

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Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder that has no definite cure. Currently, there is great interest in using plant-based medicines to treat AD. In the present study, the neuroprotective effects of Astragalus kahiricus root extract were evaluated in a retrograde amnesia model. Methods: Male albino mice were given four training sessions in the Morris water maze for seven consecutive days. Treated groups were administered A. kahiricus (25 or 50 mg/kg, i.p.) before ethanol (3.5 gm/kg, i.p) injection. All animals were given a test session in the Morris water maze apparatus. Acetylcholinesterase activity and the levels of oxidative stress biomarkers were also measured. Results: Memory impairment was observed, after ethanol administration, as increased escape latency time and path length travelled by the animals. On the other hand, A. kahiricus significantly reduced both escape latency time and path length. In addition, the extract demonstrated an inhibitory effect on acetylcholinesterase activity and total nitrite level. Moreover, A. kahiricus significantly increased the level of reduced glutathione in mice brain. Conclusion: This study demonstrated the potential behavioural and biochemical neuroprotective properties of A. kahiricus root extract, which might further be considered an important candidate for the treatment of AD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice

Abdelaziz

Helmy

Mohamed

et al. 2019

J Herbmed Pharmacol

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“…Ethyl acetate and methanol extracts + Xiao, Zhang, Qiu, Dong, & Jiang, 2014) A. eremophilus Boiss. Shkondrov et al, 2018a; A. glycyphyllos L. and enzyme inhibitory (anticholinesterase) activities (Teyeb, Mabrouk, Neffati, Douki, & Najjar, 2011;Teyeb, Zanina, Neffati, Douki, & Najjar, 2012) A. hamosus L. (Hakim, Tajuddin, Ghufran, & Nasreen, 2010;Kondeva-Burdina, Krasteva, & Mitcheva, 2014;Krasteva, Momekov, Zdraveva, Konstantinov, & Nikolov, 2008;Shojaii, Motaghinejad, Norouzi, & Motevalian, 2015;Verotta et al, 2002) Aqueous and alcoholic extracts + (Hakim et al, 2010;Kondeva-Burdina et al, 2014;Shojaii et al, 2015;Verotta et al, 2002) Rhamnocitrin 4-β-D-galactopyranoside + + (Hakim et al, 2010;Kondeva-Burdina et al, 2014;Shojaii et al, 2015;Verotta et al, 2002) Rhamnocitrin 4 0 -β-D-galactopyranoside +…”

Section: Antiinfective Properties Of the Astragalus Sppmentioning

confidence: 99%

Astragalus species: Insights on its chemical composition toward pharmacological applications

Salehi

Carneiro

Rocha

et al. 2020

Phytotherapy Research

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Astragalus L. is widely distributed throughout the temperate regions of Europe, Asia, and North America. The genus is widely used in folk medicine and in dietary supplements, as well as in cosmetics, teas, coffee, vegetable gums, and as forage for animals.The major phytoconstituents of Astragalus species with beneficial properties are saponins, flavonoids, and polysaccharides. Astragalus extracts and their isolated components exhibited promising in vitro and in vivo biological activities, including antiaging, antiinfective, cytoprotective, antiinflammatory, antioxidant, antitumor, antidiabesity, and immune-enhancing properties. Considering their proven therapeutic potential, the aim of this work is to give a comprehensive summary of the Astragalus spp. and their active components, in an attempt to provide new insight for further clinical development of these xenobiotics. This is the first review that briefly describes their ethnopharmacology, composition, biological, and toxicological properties.

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“…The anticholinesterase activity was determined by colorimetry using a Cholinesterase Kit (Chronolab, Spain). 28 PEA and PEB stock solutions were prepared by dissolution 20 mg of PEA or PEB in 2 mL of 10 % DMSO (Sigma-Aldrich). Human Plasma was provided from the Biochemistry-Toxicology Laboratory, University Hospital "Fattouma Bourguiba" of Monastir (Tunisia) and used as a source of butyrylcholinesterase (BChE).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Antimicrobial, antioxidant, cytotoxic and anticholinesterase activities of water-soluble polysaccharides extracted from microalgae Isochrysis galbana and Nannochloropsis oculata

et al. 2017

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The present work is carried out to evaluate potential applications of aqueous extracts of two microalgae Isochrysis galbana (PEA) and Nannochloropsis oculata (PEB) containing mainly polysaccharides. The monosaccharide composition of microalgal extracts was determined. GC-MS analyses after derivatization show that glucose is the major compound in both microalgae PEA (56.88 %) and PEB (68.23 %). Mannitol (38.8 %) and inositol (20.32 %) are respectively the second major compounds in PEA and PEB. Silylation of monosaccharides allows the determination of sorbitol that attained 3.38 % in PEB. The determination of antioxidant, antimicrobial and cytotoxic properties were also analyzed. Antioxidant activity was evaluated from the DPPH scavenging activity. PEA and PEB show a concentration dependent DPPH·radical scavenging activity. At concentration of 10 mg/mL, both PEA and PEB exhibit an antioxidant activity of 41.45 and 59.07 %, respectively. PEB and PEA are able to inhibit the growth of Gram-negative bacteria, Grampositive bacteria and three Candida species. Cytotoxic activity was evaluated on human HeLa cervical cancer cells. HeLa cell proliferation was totally inhibited after treatment with PEA and PEB (1 mg/mL) and the inhibition was dose dependent (from 0.031 to 1 mg/mL). Their anticholinesterase activity was also investigated against butyrylcholinesterase enzymes. These polysaccharides possess interesting antimicrobial, anticancer and anticholinesterase activities that could represent an additional value for these microalgal products.

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Anticholinesterase Activity ofAstragalus gombiformisExtracts

Cited by 5 publications

References 18 publications

Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice

Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice

Astragalus species: Insights on its chemical composition toward pharmacological applications

Antimicrobial, antioxidant, cytotoxic and anticholinesterase activities of water-soluble polysaccharides extracted from microalgae Isochrysis galbana and Nannochloropsis oculata

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