Anticholinesterase Drugs in the Treatment of Tetrodotoxin Poisoning

Chew, Suok Kai; Chew, L.S.; Wang, Kuo Weng; Mah, P. K.; Tan, Bock Yam

doi:10.1016/s0140-6736(84)90282-4

Cited by 26 publications

(4 citation statements)

References 2 publications

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“…Chew et al ., 1984 [200] have tried to make use of an anti-cholinesterase drug for treating TTX. During the large TTX incident in Bangladesh [19], 21 victims were given anticholinesterases; neostigmine and atropine but it wasn’t seen to improve their condition.…”

Section: Clinical Studymentioning

confidence: 99%

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Bane

Lehane

Dikshit

et al. 2014

Toxins

325

286

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Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan. TTX was believed to be confined to regions of South East Asia, but recent studies have demonstrated that the toxin has spread to regions in the Pacific and the Mediterranean. There is no known antidote to TTX which is a powerful sodium channel inhibitor. This review aims to collect pertinent information available to date on TTX and its analogues with a special emphasis on the structure, aetiology, distribution, effects and the analytical methods employed for its detection.

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Section: Clinical Studymentioning

confidence: 99%

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Bane

Lehane

Dikshit

et al. 2014

Toxins

325

286

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“…Notwithstanding that in 1984 a work group tried to make use of an anti-cholinesterase drug for treating TTX poisoning, no known antidote exists nowadays [ 97 ].…”

Section: Therapies For Ttx Intoxicationmentioning

confidence: 99%

Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses

et al. 2015

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Tetrodotoxin (TTX) is a potent neurotoxin responsible for many human intoxications and fatalities each year. The origin of TTX is unknown, but in the pufferfish, it seems to be produced by endosymbiotic bacteria that often seem to be passed down the food chain. The ingestion of contaminated pufferfish, considered the most delicious fish in Japan, is the usual route of toxicity. This neurotoxin, reported as a threat to human health in Asian countries, has spread to the Pacific and Mediterranean, due to the increase of temperature waters worldwide. TTX, for which there is no known antidote, inhibits sodium channel producing heart failure in many cases and consequently death. In Japan, a regulatory limit of 2 mg eq TTX/kg was established, although the restaurant preparation of “fugu” is strictly controlled by law and only chefs qualified are allowed to prepare the fish. Due to its paralysis effect, this neurotoxin could be used in the medical field as an analgesic to treat some cancer pains.

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“…A notable example of this includes the use of anti-cholinesterase drugs in treating TTX poisoning. A 1984 study described anti-cholinesterase drugs, specifically edrophonium, being helpful for poisoning after using it to treat patients suffering from poisoning [17]. In later cases in 2008 [11] and 2018 [16], the anticholinesterase drug neostigmine is given to patients suffering from TTX poisoning.…”

Section: Treatment With Disputed Resultsmentioning

confidence: 99%

Treatment of Tetrodotoxin Poisoning

2023

TNS

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Tetrodotoxin (TTX), a natural toxin found in pufferfish and other organisms causes poisoning in many people who consume inadequately prepared fugu, a Japanese delicacy containing pufferfish. TTX functions as a voltage-gated sodium channel blocker and is highly toxic, with current treatment being only supportive. This review summarizes the current state of treatment of TTX poisoning, including current treatments and supportive care along with potential treatments from anti-TTX antibodies and vaccines tested in mice, but not yet in humans. Current treatment of TTX poisoning contains offering the patient respiratory support and treating the poisoning symptomatically. Multiple antibodies and antiserums against TTX have been developed and tested both in vitro and in vivo, and showed anti-TTX effect in mice, but not yet advanced to the stage of human testing.

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Anticholinesterase Drugs in the Treatment of Tetrodotoxin Poisoning

Cited by 26 publications

References 2 publications

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses

Treatment of Tetrodotoxin Poisoning

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