Antichronic Gastric Ulcer Effect of Zinc-Baicalin Complex on the Acetic Acid-Induced Chronic Gastric Ulcer Rat Model

Abstract

Background Baicalin (BA) has been shown to have anti-inflammatory and antioxidant activity. Zinc is a nutrient element. Objective This study is aimed at investigating the antichronic gastric ulcer activity of Zn-Baicalin complex (BA-Zn) and its related mechanisms in an acetic acid-induced gastric ulcer rat model. Results The severely ulcerated gastric mucosa of model rats had lower GSH-Px (52.21 ± 7.13) and SOD (7.03 ± 0.10) activity, and higher MDA (2.39 ± 0.03) content compared to sham rats. BA-Zn reduced the gastric ulcer index in a dose-dependent manner, significantly increased SOD activity and GSH-Px level, and reduced the MDA content and IL-8 and TNF-α levels in the gastric mucosa. BA-Zn (6.5 and 13 mg/kg) exerted a greater antiulcerogenic effect than both BA and zinc-gluconate, leading to a reduced ulcer index (18.43 ± 1.11, 15.00 ± 1.44), decreased MDA content (1.33 ± 0.07, 0.63 ± 0.01), and increased SOD activity (17.62 ± 0.11, 20.12 ± 0.32) and GSH-Px levels (102.12 ± 9.11, 120.25 ± 9.07). In addition, our results from Western blot suggested that BA-Zn (6.5 and 13 mg/kg) has a greater antiulcerogenic effect than both BA and zinc-gluconate. Conclusion The BA-Zn complex possesses greater antichronic gastric ulcer properties compared to BA and zinc-gluconate due to its ability of oxidation resistance and anti-inflammatory effects.

A Review of the Role of Flavonoids in Peptic Ulcer (2010–2020)

“…In addition, the Zinc–Baicalin (BA–Zn) complex was evaluated in the acetic acid model in rats, showing significant anti-inflammatory and antioxidant effects. BA-Zn (6.5 and 13 mg/kg) increased SOD activity and GPx level and reduced the MDA content and IL-8 and TNF-α levels in the gastric mucosa [ 85 ].…”

“…Their development involves changes in the levels of PGE 2 , NO, growth factors, and cytokines, as well as changes in the microcirculation and the mucus adhesion pattern [ 171 ]. Rutin [ 65 ], hesperdidin [ 121 ], chrysin [ 90 ], and baicalin [ 85 ] showed antiulcerogenic and healing activity in this model; it can be inferred that flavonoids were able to accelerate the healing of ulcers, thereby being an important mechanism to reduce disease recurrences.…”

Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats

“…Herbs represent excellent resources for cost-effective and readily available gastro-protective remedies without significant side effects [14,15,16,17]. Medicinal/herbal plants and extracts represent some of the most attractive resources of new drugs and have shown promising results for the treatment of gastric ulcers [17,18,19,20,21,22,23,24]. The natural products obtained from medicinal plants, including flavonoids, polyphenols, terpenoids [18], saponins [24], alkaloids [12], and mucilaginous polysaccharides [25], show immense pharmacological significance such as anti-inflammatory, antimicrobial, antiulcer, anti-oxidant, and anticancer activities [24,26,27].…”

Gastroprotective Effects of Nelumbinis Rhizomatis Nodus- Derived Carbon Dots on Ethanol-Induced Gastric Ulcers in Rats

“…SOD, CAT and GSH constitute an endogenous antioxidant system, which can be used to remove excess oxygen-derived free radicals and maintain them at physiological levels [32]. GSH-Px also plays an important role in protecting against oxidative gastric mucosal injury [33]. In this experiments, we rstly showed that ethanol administration clearly altered the gastric mucosa by macroscopic evaluation of gastric lesions, and the NRNC-CDs signi cantly reduced the areas of gastric ulcer formation and ulcer index, suggesting the ability of these CDs in protecting gastric ulcer.…”