Anticipating the fate and impact of organic environmental contaminants: A new approach applied to the pharmaceutical furosemide

Laurencé, Céline; Rivard, Michaël; Martens, Thierry; Morin, Christophe; Buisson, Didier; Bourcier, Sophie; Sablier, Michel; Oturan, Mehmet A.

doi:10.1016/j.chemosphere.2014.05.036

Cited by 31 publications

(16 citation statements)

References 55 publications

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“…Furthermore, based on data from the batch experiment, only a small variation was observed in pH (from 3 to 3.4) with different applied voltages (Fig. S1), which was in the optimum EF and BEF process reaction ranges reported by the previous literature (Laurencé et al, 2014;Sellers, 1980;Zhang et al, 2012). In conclusion, the results demonstrate the feasibility of this novel 20-L BEF process for pharmaceutical-containing wastewater treatment.…”

Section: Pharmaceuticals Elimination In Batch Modesupporting

confidence: 70%

“…Furthermore, previous BEF process studies focused mainly on wastewater containing a single pharmaceutical, while the continuous degradation of pharmaceuticals in wastewater has never been reported, let alone in terms of a 20-L system. Thus, the core purpose of current work is to develop a 20-L BEF reactor for the continuous treatment of pharmaceutical wastewater containing NSAIDs (diclofenac, ibuprofen, ketoprofen, and naproxen), an anticonvulsant (carbamazepine) and a lipid regulator (clorfibric acid), all of which Journal Pre-proof J o u r n a l P r e -p r o o f 5 have been detected in varying concentrations in urban effluent (Gurke et al, 2015;Laurencé et al, 2014;Papageorgiou et al, 2016). The previous studies regarding pharmaceuticals removal by labscale BEF process are shown in Table 1.…”

Section: Introductionmentioning

confidence: 99%

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Degradation of pharmaceuticals from wastewater in a 20-L continuous flow bio-electro-Fenton (BEF) system

Zou

Angelidaki

Yang

et al. 2020

Science of The Total Environment

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Section: Pharmaceuticals Elimination In Batch Modesupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Degradation of pharmaceuticals from wastewater in a 20-L continuous flow bio-electro-Fenton (BEF) system

Zou

Angelidaki

Yang

et al. 2020

Science of The Total Environment

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“…9a shows a summary of the degradation scheme of furosemide by SBP, with the proposed structure of the 249 m/z intermediate. A number of research groups have shown that furosemide can be degraded into smaller breakdown products by various other remediation approaches, including photodegradation [34, 35], electro-Fenton and bioremediation [36]. Table 3 summarizes of these degradation studies, showing the various furosemide breakdown products that have been previously reported.…”

Section: Resultsmentioning

confidence: 99%

LC-MSMS based screening of emerging pollutant degradation by different peroxidases

et al. 2019

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BackgroundThe presence of a wide range of bioactive organic pollutants in wastewater and municipal water sources is raising concerns about their potential effects on humans. Not surprisingly, various approaches are being explored that can efficiently degrade these persistent organic pollutants. Use of peroxidases has recently been recognized as a novel remediation approach that may have potential advantages over conventional degradation techniques. However, testing the abilities of different peroxidases to degrade diverse emerging pollutants is tedious and cumbersome.ResultsIn the present study, we present a rapid and robust approach to easily test the degradability of 21 different emerging pollutants by five different peroxidases (soybean peroxidase, chloroperoxidase, lactoperoxidase, manganese peroxidase, and horseradish peroxidase) using an LC-MSMS approach. Furthermore, this approach was also used to examine the role of a redox mediator in these enzymatic degradation assays. Our results show that some of the organic pollutants can be easily degraded by all five of the peroxidases tested, whereas others are only degraded by a specific peroxidase (or when a redox mediator was present) and there are some that are completely resistant to degradation by any of the peroxidases tested (even in the presence of a redox mediator). The degradation of furosemide and trimethoprim by soybean peroxidase and chloroperoxidase, respectively, was investigated in detail by examining the transformation products generated during their degradation. Some of the products generated during enzymatic breakdown of these pollutants have been previously reported by others, however, we report many new transformation products.ConclusionsLC-MSMS approaches, like the one described here, can be used to rapidly evaluate the potential of different peroxidases (and redox requirements) to be used as bioremediation agents. Our preliminary result shows peroxidases hold tremendous potential for being used in a final wastewater treatment step.

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“…Recently, we described the preparation of an N -arylated pyridinium . Later, the toxicological evaluation of this compound showed its ability to induce cell death by apoptosis on human neuroblastoma cells (SH-SY5Y) . Based on these preliminary results, we next aimed to prepare a series of N -arylated pyridiniums by Zincke reaction, including challenging compounds deriving from poorly nucleophilic anilines.…”

Section: Introductionmentioning

confidence: 76%

Microwaves and Aqueous Solvents Promote the Reaction of Poorly Nucleophilic Anilines with a Zincke Salt

et al. 2016

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The Zincke reaction allows the transformation of primary amines into their respective N-alkylated or N-arylated pyridinium salts. While nucleophilic primary amines (typically, aliphatic primary amines) often lead to quantitative reactions and has been documented profusely, the use of poorly nucleophilic amines still requires an in depth account. To date, the lack of nucleophilicity of the amines is redhibitory. The subject addressed in this article is a series of primary amines deriving from aniline having been engaged in Zincke reactions. Efficient transformations were obtained, even when conducted on electronically deactivated, eventually also sterically hindered, substrates. This was achieved by the combined use of microwave activation and aqueous solvents. Under our conditions, the role of water revealed indeed crucial to avoid the self-degradation of the Zincke salt, the reagent of the reaction.

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Anticipating the fate and impact of organic environmental contaminants: A new approach applied to the pharmaceutical furosemide

Cited by 31 publications

References 55 publications

Degradation of pharmaceuticals from wastewater in a 20-L continuous flow bio-electro-Fenton (BEF) system

Degradation of pharmaceuticals from wastewater in a 20-L continuous flow bio-electro-Fenton (BEF) system

LC-MSMS based screening of emerging pollutant degradation by different peroxidases

Microwaves and Aqueous Solvents Promote the Reaction of Poorly Nucleophilic Anilines with a Zincke Salt

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