The leitmotif across this edition's papers of the Forum of Systems and Complexity Science is that of 'struggling with uncertainty'.
| UNCERTAINTY -AN UNAVOIDABLE FACT OF LIFEIf certainty in a complex adaptive world is an unattainable illusion, 1 we are left with having to acknowledge the 'reality of uncertainty'. Being uncertain about something is an acknowledgement that one cannot know for sure, or that one is unable to interpret or make sense of the said something. [2][3][4][5][6] While this may be logically acceptable, it nevertheless evokes an unpleasant sense of vulnerability that most of us want to overcome by searching for more certainty (or at times constructing alternative facts).The quest for more certainty in turn has long been the driver for research, and on many accounts, research has provided us with an unprecedented level of new information (not infrequently dressed up as knowledge) about many facets of our world. Only the act of synthesizing and integrating pieces of information results in the creation of new knowledge. 7 However, we have to appreciate knowledge with an important caveatall knowledge is situated in a particular context, and that context shapes our understanding, an observation first made by Goethe and Humboldt in the 1790s (end of the Enlightenment period). 8 We only understand 'a thing' if we know how it is connected and how it interacts with 'other things' in its particular context at a particular point in time. This insight about the interconnected nature of things laid the foundations for the emergence of systems and complexity thinking, a framework to understand 'how we know what'. 2,9 Given Goethe's and Humboldt's insights it is amazing that it has had so little impact on medical research over the past nearly 230 years. Medical research is stuck in the reductionist research paradigm characterized by the 'scientific method'generate a hypothesis, set up an experiment, observe, and analyse if the hypothesis is to be rejected or accepted. Its most trustworthy application is proclaimed to be the randomized controlled trial (RCT), whose findings are widely believed to result in the most