Anticoagulant Activity of Fucoidan from Brown Algae Fucus evanescens of the Okhotsk Sea

Abstract

In vitro and in vivo experiments showed that anticoagulant activity of sulfated polysaccharide from Fucus evanescens (brown algae of the Okhotsk Sea) was similar to that of heparin. Anticoagulant properties of fucoidan are determined by thrombin inhibition mediated via plasma antithrombin III.

Structural Study of Sulfated Fuco-Oligosaccharide Branched Glucuronomannan fromKjellmaniella crassifoliaby ESI-CID-MS/MS

“…Sulfated polysaccharides, especially fucoidans, extracted from some brown algae and invertebrates have attracted considerable attention in recent years due to their interesting biological activities, for example, anticoagulant, [1,2] anti-inflammatory, [3,4] and antioxidative activities. [5][6][7] However, the relationship between the structure of fucoidans and their biological activities has not been clarified because of the complexity of their structure.…”

Fucoidan Extracted from Fucus Evanescens Brown Algae Corrects Immunity and Hemostasis Disorders in Experimental Endotoxemia

“…These signs are characteristic of the initial stage of the DIC syndrome [11][12][13][14]. Treatment with fucoidan according to the therapeutic protocol (group 2) arrested hypercoagulation, which was seen by the APTT and TT and higher FA of the blood, presumably due to the anticlotting and fibrinolytic activities of fucoidan [1,3], but the blood clotting characteristics did not reach the control level (Table 1). Preventive fucoidan treatment (group 3) induced hypocoagulation shifts, manifesting by prolonged blood clotting time in comparison with group 1 and control (p=0.000).…”

Molecular characteristics of sulfated polysaccharides from Monostroma nitidum and their in vitro anticancer and immunomodulatory activities

“…Studies on sulfated polysaccharides from marine algae have mainly focused on fucoidans, ascophyllan, sargassan and glucuronoxylofucan (from brown algae) and agar and carrageenan (from red algae) due to their effective anticoagulant, antitumor, antiviral, immunomodulatory, anti-inflammatory and antioxidant activities [1][2][3][4][5]. The sulfated polysaccharides from green algae are referred to as ulvans.…”