Anticoagulant Activity of Nucleic Acid Nanoparticles (NANPs) Assessed by Thrombin Generation Dynamics on a Fully Automated System

Immunostimulation of Fibrous Nucleic Acid Nanoparticles Can be Modulated through Aptamer-Based Functional Moieties: Unveiling the Structure–Activity Relationship and Mechanistic Insights

“…For instance, fibrous materials offer a large surface area, allowing the delivery of a more significant number of functional moieties than a spherical nanocarrier may offer. − Moreover, a nonspherical shape has been suggested to improve the vascular transport of nanomaterials and therapeutic cargo delivery into the interstitial space. , To leverage these benefits of fibrous shape while avoiding undesirable inflammatory responses, researchers turned their attention to “soft” and biodegradable materials such as those made of natural RNA and DNA biopolymers. The field of nucleic acid nanoparticles (NANPs) is fast growing and has already demonstrated numerous beneficial, safe, and environmentally friendly applications ranging from therapeutic indications − as nanomedicines to the use as structural components of light-emitting diodes, functional photonic devices, and biosensors. − …”