Anticoagulant, Antiplatelet and Antianemic Effects  of Citrus paradisi (Grape Fruit) Juice in Rabbits

Mallick, Neelam; Khan, Rafeeq Alam; Riaz, Azra; Afroz, Syeda

doi:10.4236/pp.2016.710047

Cited by 2 publications

(2 citation statements)

References 42 publications

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“…Structurally, flavonoids could be categorised into six major classes, including flavanones, flavones, flavanols, isoflavones, flavonols, and anthocyanidins [52]. Even though the flavones and flavanols are in low concentrations compared to flavanones, but are more potent antioxidants and free radical scavengers [53]. The high contents of phytochemicals, including naringin, hesperidin, limonene, and other flavonoids in citrus limon could significantly reduce the morbidity or mortality in the patients at risk of developing cardiovascular events [53].…”

Section: Traditional Medicationsmentioning

confidence: 99%

Anticoagulants and Hypercoagulability

Kwaifa¹

2022

Anticoagulation - Current Perspectives

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Anticoagulants are chemical substances that prevent coagulation or prolong the clotting time by suppressing the functions or synthesis of coagulation factors in the blood. Anticoagulation mechanisms are essential in controlling the formation of a blood clot at the site of injury. The abnormalities in the coagulation and fibrinolytic mechanisms could lead to a hypercoagulability state. Inherited hypercoagulable state due, including Factor V Leiden (FVL), prothrombin gene mutation, defective natural proteins that inhibit coagulation, including antithrombin III (ATIII), protein C and S, high levels of FVII, FIX and FXI, are well-documented. Abnormalities of the fibrinolytic system, including tissue-type plasminogen activator (t-PA) and urokinase plasminogen activator (u-PA), and elevated levels of plasminogen activator inhibitor-1 (PAI-1) have been linked to hypercoagulation. Acquired conditions, including certain cancers and their medications, trauma or surgery, pregnancy, obesity and hyperlipidaemia, have been implicated with hypercoagulable events. The clinical symptoms of hypercoagulability can be devastating and may even have lethal outcomes. This activity reviews the principles of anticoagulation, haemostasis, deficiencies associated with hypercoagulability (both coagulation and fibrinolytic disorders), mechanisms of action of some natural-based products with anticoagulant potentials and highlights new clinical and traditional therapeutic strategies to be taken in improving healthcare for patients demanding anticoagulation.

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Section: Traditional Medicationsmentioning

confidence: 99%

Anticoagulants and Hypercoagulability

Kwaifa¹

2022

Anticoagulation - Current Perspectives

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“…They are also used as natural preservatives that preserve food from different oxidative or microbial alterations [11]. Some citrus extracts, such as aqueous extracts, essential oils and juice, have already been studied for their anticoagulant activity [3,12]. They are endowed with important broad-spectrum activities [13], and have revealed great potential in their use against bacteria and fungi [14,15].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Screening of Antimicrobial and Anti-Coagulant Activities, ADME Profiling, and Molecular Docking Study of Citrus limon L. and Citrus paradisi L. Cold-Pressed Volatile Oils

Hamdi,

Horchani,

Jannet

et al. 2023

Pharmaceuticals

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Citrus, which belongs to the Rutaceae family, is a very widespread genus in the Mediterranean Basin. In Tunisia, various parts of these spontaneous or cultivated plants are used in common dishes or in traditional medicine. The purpose of this work was to investigate C. limon and C. paradisi essential oil (EO). The samples were studied for their chemical composition using SPME/MS, as well as their antibacterial and antifungal activities. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) methods were used to evaluate the anticoagulant potentialities. The obtained results show that both essential oils are rich in monoterpenes hydrocarbons, whereby limonene is the main compound in C. paradisi EO (86.8%) and C. limon EO (60.6%). Moreover, C. paradisi EO contains β-pinene (13.3%), sabinene (2.2%) and α-pinene (2.1%). The antibacterial assay of the essential oils showed important bactericidal and fungicidal effects against all strains tested. In fact, the MICs values of C. limon EO ranged from 0.625 to 2.5 mg/mL against all Gram-positive and Gram-negative bacteria, and from 6.25 to 12.5 mg/mL for Candida spp. strains, while C. paradisi EO was more active against all bacteria with low MICs values ranging from 0.192 to 0.786 mg/mL, and about 1.5 mg/mL against Candida species. Both tested Citrus EOs exhibited interesting anticoagulant activities as compared to heparin. The molecular docking approach was used to study the binding affinity and molecular interactions of all identified compounds with active sites of cytidine deaminase from Klebsiella pneumoniae (PDB: 6K63) and the C (30) carotenoid dehydrosqualene synthase from Staphylococcus aureus (PDB: 2ZCQ). The obtained results show that limonene had the highest binding score of −4.6 kcal.mol−1 with 6K63 enzyme, and −6.7 kcal.mol−1 with 2ZCQ receptor. The ADME profiling of the major constituents confirmed their important pharmacokinetic and drug-like properties. Hence, the obtained results highlight the potential use of both C. limon and C. paradisi essential oils as sources of bioactive compounds with antibacterial, antifungal, and anti-coagulant activities.

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Anticoagulant, Antiplatelet and Antianemic Effects of Citrus paradisi (Grape Fruit) Juice in Rabbits

Cited by 2 publications

References 42 publications

Anticoagulants and Hypercoagulability

Anticoagulants and Hypercoagulability

In Vitro Screening of Antimicrobial and Anti-Coagulant Activities, ADME Profiling, and Molecular Docking Study of Citrus limon L. and Citrus paradisi L. Cold-Pressed Volatile Oils

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