Anticoagulant potential of regioselective derivatized cellulose

Groth, Thomas; Wagenknecht, W.

doi:10.1016/s0142-9612(01)00013-8

Cited by 87 publications

(69 citation statements)

References 33 publications

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“…Therefore, a lower degree of O-6-sulfation may also contribute to the results observed in this study. This pattern is also known to be important for the blood-coagulating activity of cellulose sulfates (23).…”

Section: Discussionmentioning

confidence: 89%

Inhibition of Chondroitin-4-Sulfate-Specific Adhesion of Plasmodium falciparum -Infected Erythrocytes by Sulfated Polysaccharides

et al. 2005

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Adhesion of Plasmodium falciparum-infected erythrocytes to placental chondroitin 4-sulfate (CSA) has been linked to the severe disease outcome of pregnancy-associated malaria. Soluble polysaccharides that release mature-stage parasitized erythrocytes into the peripheral circulation may help elucidate these interactions and have the potential to aid in developing therapeutic strategies. We have screened a panel of 11 sulfated polysaccharides for their capacities to inhibit adhesion of infected erythrocytes to CSA expressed on CHO-K1 cells and ex vivo human placental tissue. Two carrageenans and a cellulose sulfate (CS10) were able to inhibit adhesion to CSA and to cause already bound infected erythrocytes to de-adhere in a dose-dependent manner. CS10, like CSA and in contrast to all other compounds tested, remained bound to infected erythrocytes after washing and continued to inhibit binding. Both carrageenans and CS10 inhibited adhesion to placental tissue. Although highly sulfated dextran sulfate can inhibit CSA-mediated adhesion to CHO cells, this polysaccharide amplified adhesion to placental tissue severalfold, demonstrating the importance of evaluating inhibitory compounds in systems as close to in vivo as possible. Interestingly, and in contrast to all other compounds tested, which had a random distribution of sulfate groups, CS10 exhibited a clustered sulfate pattern along the polymer chain, similar to that of the undersulfated placental CSA preferred by placental-tissue-binding infected erythrocytes. Therefore, the specific antiadhesive capacity observed here seems to depend not only on the degree of charge and sulfation but also on a particular pattern of sulfation.

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Section: Discussionmentioning

confidence: 89%

Inhibition of Chondroitin-4-Sulfate-Specific Adhesion of Plasmodium falciparum -Infected Erythrocytes by Sulfated Polysaccharides

et al. 2005

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“…Beyond that, partially sulfated cellulose was considered promising for biomaterials coatings [10]. Due to their action on AT, such coatings were demonstrated to reduce the coagulation processes at the blood/material interface [11][12][13]. Such coatings could be useful for the surface-selective modification of catheters and several other devices temporarily applied in direct blood contact.…”

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confidence: 99%

Sulfated cellulose thin films with antithrombin affinity

Grombe¹,

Gouzy²,

Freudenberg³

et al. 2009

Express Polym. Lett.

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Cellulose thin films were chemically modified by in situ sulfation to produce surfaces with anticoagulant characteristics. Two celluloses differing in their degree of polymerization (DP): CEL I (DP 215–240) and CEL II (DP 1300–1400) were tethered to maleic anhydride copolymer (MA) layers and subsequently exposed to SO3•NMe3 solutions at elevated temperature. The impact of the resulting sulfation on the physicochemical properties of the cellulose films was investigated with respect to film thickness, atomic composition, wettability and roughness. The sulfation was optimized to gain a maximal surface concentration of sulfate groups. The scavenging of antithrombin (AT) by the surfaces was determined to conclude on their potential anticoagulant properties

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“…The demand for effective and non-toxic antibacterial therapeutics has become even greater with the increased incidence of bacterial infections. Substances with anticoagulant activity are among the first choices as functional components which are being used to open up new areas of application for anticoagulant pathogens [3] .…”

Section: Introductionmentioning

confidence: 99%