Anticoagulant Therapy For Acute Coronary Syndromes

Onwordi, Eunice; Gamal, Amr; Zaman, Azfar

doi:10.15420/icr.2017:26:1

Cited by 13 publications

(16 citation statements)

References 67 publications

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“…Fondaparinux is a low molecular weight heparin anticoagulant and is one of the first synthetic molecules developed for targeted action against specific coagulation proteins [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Effectiveness and Tolerability of Fondaparinux in the Management of Symptomatic Acute Coronary Syndrome: A Real-World Evidence-Based Study on an Indian Population

Dalal

Mohan

Sathe³

et al. 2022

Cardiol Ther

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Introduction : Fondaparinux is a low molecular weight heparin anticoagulant used to manage the full spectrum of acute coronary syndrome (ACS) patients and has proved its efficacy and safety in multiple clinical trials. However, there are limited data available showing whether the same results could be reproduced in real-world practice on an Indian population. Our objective was to determine the effectiveness and tolerability of fondaparinux in the management of symptomatic ACS in real-world clinical practice. Methods: The EMR data of hospitalized ACS patients (n = 611), from January 2015 to January 2020, representing UA or NSTEMI or STEMI and were prescribed fondaparinux (2.5 mg once daily) to manage ACS were analyzed. The effectiveness was analyzed as recurrence of ACS and tolerability as total incidence of major bleeding during hospitalization, at 30 days and 180 days. Appropriate statistical analysis was used with a statistically significance of p value \ 0.05.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Effectiveness and Tolerability of Fondaparinux in the Management of Symptomatic Acute Coronary Syndrome: A Real-World Evidence-Based Study on an Indian Population

Dalal

Mohan

Sathe³

et al. 2022

Cardiol Ther

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“…Antithrombotic therapy is the first-line treatments for the prevention of CVDs, but they also significantly increase the risk of bleeding [20]. It remains a great challenge to effectively balance the ischemic risk reduction and the risk of bleeding [90]. Situations like these call for the need of developing nanomedicine that can target the disease area for drug delivery yet minimizing the side effects.…”

Section: Targeted Delivery Systemmentioning

confidence: 99%

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

2020

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Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. Objective: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. Method: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. Results: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. Conclusion: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.

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“…However, the lymphatic system is only scarcely involved following IV injections [ 232 , 233 , 234 ]. Table 6 presents several conditions treated with this type of injection [ 74 , 83 , 85 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 ].…”

Section: Treating Cvd Through Various Administration Routesmentioning

confidence: 99%

Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine

et al. 2021

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While oral agents have been the gold standard for cardiovascular disease therapy, the new generation of treatments is switching to other administration options that offer reduced dosing frequency and more efficacy. The lymphatic network is a unidirectional and low-pressure vascular system that is responsible for the absorption of interstitial fluids, molecules, and cells from the peripheral tissue, including the skin and the intestines. Targeting the lymphatic route for drug delivery employing traditional or new technologies and drug formulations is exponentially gaining attention in the quest to avoid the hepatic first-pass effect. The present review will give an overview of the current knowledge on the involvement of the lymphatic vessels in drug delivery in the context of cardiovascular disease.

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Anticoagulant Therapy For Acute Coronary Syndromes

Cited by 13 publications

References 67 publications

Evaluation of Effectiveness and Tolerability of Fondaparinux in the Management of Symptomatic Acute Coronary Syndrome: A Real-World Evidence-Based Study on an Indian Population

Evaluation of Effectiveness and Tolerability of Fondaparinux in the Management of Symptomatic Acute Coronary Syndrome: A Real-World Evidence-Based Study on an Indian Population

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine

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