Anticoagulation in Atrial Fibrillation

Werdan, Karl; Braun-Dullaeus, Rüdiger C.; Presek, Peter

doi:10.3238/arztebl.2013.0523

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Anticoagulants remain the mainstay in the pharmacological management of thromboembolic disorder and have proven over the years to be effective and safe [ 6 ]. Despite the effectiveness of conventional pharmacological agents in the management of thromboembolic disorders, they are often associated with unfavorable side effects such as increased risk of bleeding and gastric ulceration and also prohibitive high treatment cost [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Anticoagulant effect and safety assessment of an aqueous extract of Pseudocedrela kotschyi (Schweinf.) Harms and Adenia cissampeloides (Planch. Ex Hook.) Harms

Nyansah

Koffuor

Asare

et al. 2016

J Intercult Ethnopharmacol

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Background:Currently available therapeutic options for thromboembolic disorders are often very expensive and are associated with unfavorable side effects.Aim:To establish the anticoagulant effect and safety profile of an extract made from of the root bark of Pseudocedrela kotschyi (Schweinf.) Harms and the aerial part of Adenia cissampeloides (Planch. ex Hook.) Harms (PAE).Materials and Methods:PAE (0.5-2.0 g/L) effect on prothrombin time (PT) and activated partial thromboplastin time (aPTT) were evaluated on whole blood drawn from the marginal ear vein of New Zealand White rabbits. Effect of PAE (250-2000 mg/kg) on bleeding time (BT) and clotting time (CT) in Sprague-Dawley rats were also assessed. Histopathological, hematological, and liver function studies were also carried out to assess the safety for use of PAE (250-2000 mg/kg).Results:PAE had no significant effect (P > 0.05) on PT, but resulted in a significant increase (P ≤ 0.05-0.0001) in aPTT. The PAE treatment resulted in a significant increase (P ≤ 0.05-0.0001) in BT and CT in vivo compared with control. Safety studies indicated no deaths with PAE treatment with hematological and liver function tests being normal. Histological studies revealed pathological changes in the liver at a PAE treatment dose of 2000 mg/kg but all doses had no detrimental effect on kidney and stomach tissue. The no-observed-adverse-effect-level was <2000 mg/kg when given orally.Conclusion:PAE has anticoagulant effect in vitro and is safe to use at oral doses <2000 mg/kg.

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Section: Introductionmentioning

confidence: 99%

Anticoagulant effect and safety assessment of an aqueous extract of Pseudocedrela kotschyi (Schweinf.) Harms and Adenia cissampeloides (Planch. Ex Hook.) Harms

Nyansah

Koffuor

Asare

et al. 2016

J Intercult Ethnopharmacol

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“…The merit of the trial by Stefan Viktor Vormfelde and coauthors that appears in this issue of Deutsches Ärzteblatt International is to have extended our knowledge that patient education does, in fact, work to the area of therapeutic anticoagulation with phenprocoumon-and to have done so with an innovative, interactive study design that was directly implemented in general practitioners' practices (3). Many patients are still being treated with phenprocoumon, and, in view of the current debate about the safety of the newer anticoagulant drugs (4), permanent anticoagulation with phenprocoumon will likely continue to play an important role in patient care (5). Thus, the method of patient education used in this trial will continue to be important.…”

Section: Self-managementmentioning

confidence: 99%

Modern Education, Modern Media

Schneider

2014

Deutsches Ärzteblatt International

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“…Estimates of the incidence of upper GI bleeding range between 50 to 150 cases per 100,000 citizens annually, depending on geographic localization [1]. Moreover, the incidence of patients requiring anticoagulant and anti-platelet medications due to cardiac or vascular comorbidity continues to rise [2,3]. These patients are also more commonly treated for concomitant diseases such as diabetes or chronic renal insufficiency, which may worsen the overall prognosis.…”

Section: Introductionmentioning

confidence: 99%

The use of prognostic scales in upper gastrointestinal tract bleeding.

et al. 2021

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IntroductionIn order to select high-risk patients, many prognostic scales have been invented. Among them, Rockall, Glasgow-Blatchford and AIMS 65 scales were considered the most useful.Material and methodsPatients with upper GI tract bleeding, treated between 2017 and 2018 were retrospectively enrolled to the study. Every patient had a Rockall, Glasgow-Blatchford and AIMS 65 score calculated retrospectively. Data on hospitalization as blood transfusions, length of hospital stay, rebleeding, intensive care unit (ICU) admission, mortality was included into data-base.ResultsUnivariate logistic regression revealed that only the AIMS65 scale was a prognostic factor for in-hospital mortality (OR 11.028; 95% CI: [2.271, 53.563], p=0.001). The AIMS 65 score >2 was the only factor predicting the need of >4 blood units transfusion during hospitalization (OR 3.977; 95% CI: [1.305, 12.122], p=0.015), whereas Glasgow-Blatchford scale >5 was the only risk factor for the need of fresh frozen plasma transfusion (OR 3.657; 95% CI: [1.010-13.242], p=0.048). The area under a curve (AUC) in the ROC analysis revealed that the AIMS 65 scale was the most accurate in mortality prediction (AUC=0.859, p=0.002), whereas Rockall score and Glasgow-Blatchford were not significant (AUC=0.614, p=0.093 and AUC=0.504, p=0.97, respectively).ConclusionsBased on our results, we recommend using AIMS 65 scoring system. It’s simple and requires few of parameters to be counted. Also, it proved to be the most efficient in predicting in-hospital mortality.

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Anticoagulation in Atrial Fibrillation

Cited by 6 publications

References 12 publications

Anticoagulant effect and safety assessment of an aqueous extract of Pseudocedrela kotschyi (Schweinf.) Harms and Adenia cissampeloides (Planch. Ex Hook.) Harms

Anticoagulant effect and safety assessment of an aqueous extract of Pseudocedrela kotschyi (Schweinf.) Harms and Adenia cissampeloides (Planch. Ex Hook.) Harms

Modern Education, Modern Media

The use of prognostic scales in upper gastrointestinal tract bleeding.

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