Anticoagulation Therapy in Microsurgery: A Review

Askari, Morad; Fisher, Christine M.; Weniger, Frederick G.; Bidic, Sean M.; Lee, W. P.Andrew

doi:10.1016/j.jhsa.2006.02.023

Cited by 114 publications

(88 citation statements)

References 85 publications

(105 reference statements)

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“…Although thrombolytic agents such as streptokinase, urokinase and tPA have been proven to reverse the microvascular thrombosis in the animal models, reports suggesting their efficacy with human subjects are scanty (Askari et al 2006). Rooks et al (1994) had observed that the use of urokinase on an A brief summary of the various assays described in the manuscript has been provided in Table 2.…”

Section: Other Models Based On Thrombus Formationmentioning

confidence: 99%

Methods available to assess therapeutic potential of fibrinolytic enzymes of microbial origin: a review

2018

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Fibrinolytic enzymes are agents administered for the treatment of myocardial infarctions, strokes, cardiac and respiratory failure. Although several microorganisms are known to produce these fibrinolytic enzymes, only a few of such enzymes, along with the age-old oral anticoagulants, have been employed in the clinical and therapeutic applications in humans. The use of these agents is associated with drawbacks such as allergic reactions and bleeding complications; therefore, it necessitates frequent monitoring of drug levels in the blood. Due to this, there is an impetus on the current effort to identify newer potential candidates from the novel microbial sources which show longer half-life, higher fibrin specificity, higher therapeutic index and lesser allergic reactions. Various methods are available for the preliminary evaluation of a potential drug candidate for the therapeutic use. Choosing the right combination of in vitro and in vivo methods would give crucial insight on the therapeutic potential of the chosen test compound. This article discusses various assay techniques, in vitro trails and in vivo models available, to help researchers in choosing right biological methods and its combinations to evaluate efficacy of potential drug candidate.

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Section: Other Models Based On Thrombus Formationmentioning

confidence: 99%

Methods available to assess therapeutic potential of fibrinolytic enzymes of microbial origin: a review

2018

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“…The pharmacologic agents used to produce these effects are aspirin, heparin, low-molecular-weight heparin, dextran, dipyridamole, and chlorpromazine. 5 Acetylsalicylic acid (aspirin) acts by inhibiting the enzyme cyclooxygenase and prevents catalysis of the synthesis of thromboxane A2 (a potent vasoconstrictor that also initiates platelet aggregation) from its biochemical precursor, arachidonic acid. Because of its binding effect on cyclooxygenase, aspirin has an irreversible effect on circulating platelets and will inhibit aggregation for the duration of the platelet's life in the circulation of approximately 8 to 10 days.…”

mentioning

confidence: 99%

“…It requires no monitoring and can be administered on an outpatient basis. 5,6 It has not been shown to be of benefit, however, in patients who have had replantation of an amputated part.…”

mentioning

confidence: 99%

Clinical Use of Anticoagulants Following Replantation Surgery

Levin

Cooper

2008

The Journal of Hand Surgery

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“…The free flap suffering or failure is a complication that often requires, after a rapid recognition of the clinical aspect of the flap, the surgical re-exploration in order to remove haematomas, seroma over the pedicle or to perform a new anastomoses [2]. Sometime the venous congestion of the flap is caused by a temporary problem (spasm) that could not require a surgical revision of the anastomosis.…”

Section: Resultsmentioning

confidence: 99%

Transdermal Nitroglycerine Patch: An Optional Device to Reduce Flap Venous Congestion? A Case Report

Lorenzo¹,

Corradino²,

Cordova³

2013

MPS

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Sometimes in free flap there is a venous congestion without an obstruction of the venous anastomosis or other organic causes of reduction venous drainage (haematoma, seroma compressing the pedicle). In these cases the authors suggest the application of nitroglycerine patch in the congested area of the flap few hours before the surgical exploration of the anastomosis. If there is a fast improvement of the clinical feature of the flap, the surgical exploration could be avoided. The authors underline that applying the nitroglycerin patch should not be regarded in any way as a therapy of a free flap venous thrombosis but only as an useful device, an option to be taken only when the surgeon is undecided whether to revisit the anastomosis or not.

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Anticoagulation Therapy in Microsurgery: A Review

Cited by 114 publications

References 85 publications

Methods available to assess therapeutic potential of fibrinolytic enzymes of microbial origin: a review

Methods available to assess therapeutic potential of fibrinolytic enzymes of microbial origin: a review

Clinical Use of Anticoagulants Following Replantation Surgery

Transdermal Nitroglycerine Patch: An Optional Device to Reduce Flap Venous Congestion? A Case Report

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