Anticoagulation with Warfarin in Infants and Children

Buck, Marcia L.

doi:10.1177/106002809603001117

Cited by 23 publications

(21 citation statements)

References 48 publications

(12 reference statements)

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“…This finding has been reported in several other recent studies as well [2][3][4]. Similarly, children between the ages of 1 and 6 years of age were also found to need an increased dosage of warfarin compared to older children between 6 and 18 years of age.…”

Section: Warfarin Therapysupporting

confidence: 72%

Congenital heart disease: Current indications for antithrombotic therapy in pediatric patients

Reller

2001

Curr Cardiol Rep

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Section: Warfarin Therapysupporting

confidence: 72%

Congenital heart disease: Current indications for antithrombotic therapy in pediatric patients

Reller

2001

Curr Cardiol Rep

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“…The volume of distribution is about 18 L and total clearance after a single intravenous dose is about 4 L h -1 in patients with pulmonary arterial hypertension. [1][2][3][4][5] Quantification of drugs in biological matrices such as blood, serum and urine, is required in modern therapeutics to optimize a drug dosage according to personalized medicine strategies. In addition to clinical applications of these analyses, they are used in pharmaceutical industry to evaluate pharmacokinetic profile of a new drug and/or evaluating bioequivalency of a new oral drug formulation.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Ultrasound Assisted and Dispersive Liquid-Liquid Microextractions Combined with HPLC-UV Method for Determination of Bosentan in Human Plasma and Urine

Sajedi-Amin

Asadpour‐Zeynali

Khoubnasabjafari

et al. 2016

J. Braz. Chem. Soc.

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A feasible, rapid, sensitive and reliable dispersive liquid-liquid microextraction (DLLME) and ultrasonic assisted liquid-liquid microextraction (USAEME) combined with high-performance liquid chromatography (HPLC) method with UV detection was developed and validated for analysis of bosentan in human plasma and urine samples. All validation tests were reported according to FDA guidelines. Since chromatographic methods are precise, accurate and provide excellent separation are increasingly being used in determination of trace amount of drugs in biological goals. So the optimized experimental extraction factors from our previous work were used to evaluate HPLC-UV method for decreasing the limit of quantifications (LOQs) to cover the therapeutic range. Simple centrifugation of urine samples was sufficient prior to microextraction procedure, while acetonitrile protein precipitation provides sample clean up for plasma samples. The suggested method was linear (correlation coefficient R 2 > 0.998) over a range of 0.1-10 μg mL -1 which covers the therapeutic range. Proposed methods are practical for quantitative analysis of bosentan in real samples, and could be used in routine clinical analyses.

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“…Recommended target INR range in children is from 1.5 to 313, 16,19,21. This concern is due to problems of anticoagulation, future pregnancy, possibility of reoperation to keep pace with somatic growth, early calcification in case of bioprosthetic valves and associated congenital cardiac malformations 1,2,9,3°.…”

Section: Discussionmentioning

confidence: 99%

Pediatric valve replacement, 15 years experience in Oman

Gopal

Taha

Valliathu

et al. 2006

Indian J Thorac Cardiovasc Surg

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Background: Despite improving surgical techniques, treatment of heart valve disease in children remains controversial. Somatic growth and adequate anticoagulation are of concern when children undergo valve replacement. We conducted this study to evaluate the performance of valves in this age group.Methods: 42 children under the age of 13 years who underwent valve replacement were included in this study. Totally, 50 valves were implanted in 42 patients: 48 were mechanical prostheses, two were bioprosthetic both in pulmonary position. 37 (74%) valves were implanted in mitral position, 10 (20%) in aortic position, 1 (2%) in tricuspid position and 2 (4%) in pulmonary position. Preoperatively, 14 (33.3%) patients were in New York Heart Association (NYHA) class IV, while 27 (64.2%) were in NYHA class III.Results: There were 2 (4.7%) hospital deaths and 2 (4.7%) late deaths while 2 (4.7%) patients were lost to follow up. The mean follow up period was 9.4 yrs. 35 (83.3%) patients are in NYHA Class I and free of all medications except warfarin. 3 (7.1%) patients have undergone 5 successful pregnancies. The median INR was 2.23. Major thrombo-embolic episode occurred in 1 (2.3%) patient. Conclusions :In view of the problems of sizing, anticoagulation and need for re-operation at an early age, there is a reluctance to replace valves in children. This study shows that despite these problems, valve replacement can be undertaken safely and successfully in children, when repair has failed or not technically feasible. (Ind J Thorac Cardiovasc Surg, 2006; 22: 173-177)

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Anticoagulation with Warfarin in Infants and Children

Abstract: Due to its infrequent use, there is limited information on the effects of warfarin in children. Basic guidelines for initiating and monitoring warfarin were developed by using data gathered from clinical trials, retrospective reviews, case series, and surveys of practice.

Cited by 23 publications

References 48 publications

Congenital heart disease: Current indications for antithrombotic therapy in pediatric patients

Congenital heart disease: Current indications for antithrombotic therapy in pediatric patients

Development and Validation of Ultrasound Assisted and Dispersive Liquid-Liquid Microextractions Combined with HPLC-UV Method for Determination of Bosentan in Human Plasma and Urine

Pediatric valve replacement, 15 years experience in Oman

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