Anticolitic activity of prodigiosin loaded with selenium nanoparticles on acetic acid–induced colitis in rats

Kassab, Rami B.; Elbaz, Mohamad; Oyouni, Atif Abdulwahab A.; Mufti, Ahmad H.; Theyab, Abdulrahman; Albrakati, Ashraf; Mohamed, Hany A.; Hebishy, Ali M. S.; Elmallah, Mohammed I. Y.; Abdelfattah, Mohamed S.; Moneim, Ahmed E. Abdel

doi:10.1007/s11356-022-19747-1

Cited by 11 publications

(11 citation statements)

References 57 publications

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“…However, there is no study in the literature about iNOS levels in a rat heart exposed to ACR. Studies on different tissues found that SEL reduced iNOS levels compared to the damage groups (54,55). The decrement of iNOS expressions in SEL treated groups showed that SEL has an anti-inflammatory effect against ACR induced cardiac damage.…”

Section: Parameters / Groupmentioning

confidence: 93%

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

KARAKUYU

Aşçı

Savran

et al. 2023

SDÜ Tıp Fakültesi Dergisi

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Objective: Acrylamide (ACR) is a harmful organic reactive compound widely used in different industrial fields. Selenium (SEL) is a trace element that takes part in some chemical and enzymatic reactions in both animals and human organisms and can cause some disorders in many systems such as the cardiovascular system in case of deficiency. The aim of this study is to investigate whether SEL has a protective effect on cardiac tissue in experimentally induced ACR toxicity in rats. Material and Methods: A total of 28 rats were randomly and equally divided into four groups: Control, SEL, ACR, SEL + ACR. At the end of the study, cardiac markers such as creatine kinase MB (CKMB), lactate dehydrogenase (LDH) and ischemia-modified albumin (IMA) from blood samples were measured. Oxidative stress markers such as total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) in heart tissue were analyzed. In addition, inducible nitric oxide synthase iNOS activities were determined in heart sections using immunohistochemical methods. Results: The ACR + SEL group showed a significant decrease in TOS, OSI, CKMB, LDH, IMA levels and significant increase in TAS level compared to the ACR group. In histopathological and immunohistochemical evaluation of the heart sections; Disorganization in cardiac muscle fibers, increased connective tissue between muscle fibers and irregular eosinophilia in muscle fibers were detected in ACR group. A decrease in histopathological findings was observed in the SEL treated group compared to the ACR group. iNOS immunoreactivities; Moderate marking was observed in the ACR group sections, while poor marking was observed in the treatment group. Conclusion: We determined that ACR caused damage to the heart tissue of rats through various metabolic pathways and that these damages were reversed in the groups given the SEL.

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Section: Parameters / Groupmentioning

confidence: 93%

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

KARAKUYU

Aşçı

Savran

et al. 2023

SDÜ Tıp Fakültesi Dergisi

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“…Lowering pro-apoptotic factors [Bax and caspase-3] and raising anti-apoptotic protein, Bcl2, PGs-SeNPs prevented intestinal cells from dying by blocking the apoptotic pathway. Due to its powerful anti-inflammatory, antioxidant, and anti-apoptotic properties, PGs-SeNPs might be employed as an alternate anti-colitic strategy [ 29 ].…”

Section: Role Of Senps In Several Diseasesmentioning

confidence: 99%

Recent advances in the therapeutic applications of selenium nanoparticles

Ansari,

Malik,

Ahmed

et al. 2024

Mol Biol Rep

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Selenium nanoparticles (SeNPs) are an appealing carrier for the targeted delivery. The selenium nanoparticles are gaining global attention because of the potential therapeutic applications in several diseases e.g., rheumatoid arthritis (RA), inflammatory bowel disease (IBD), asthma, liver, and various autoimmune disorders like psoriasis, cancer, diabetes, and a variety of infectious diseases. Despite the fact still there is no recent literature that summarises the therapeutic applications of SeNPs. There are some challenges that need to be addressed like finding targets for SeNPs in various diseases, and the various functionalization techniques utilized to increase SeNP’s stability while facilitating wide drug-loaded SeNP distribution to tumor areas and preventing off-target impacts need to focus on understanding more about the therapeutic aspects for better understanding the science behind it. Keeping that in mind we have focused on this gap and try to summarize all recent key targeted therapies for SeNPs in cancer treatment and the numerous functionalization strategies. We have also focused on recent advancements in SeNP functionalization methodologies and mechanisms for biomedical applications, particularly in anticancer, anti-inflammatory, and anti-infection therapeutics. Based on our observation we found that SeNPs could potentially be useful in suppressing viral epidemics, like the ongoing COVID-19 pandemic, in complement to their antibacterial and antiparasitic uses. SeNPs are significant nanoplatforms with numerous desirable properties for clinical translation. Graphical Abstract

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“…CXB was previously encapsulated into several nanocarriers such as casein NPs, chitosan-fucoidan NPs, polylactide-Co-Glycolide NPs, inulin-based Nano micelles, PEGylated liposomes and solid lipid NPs 33 – 38 . Due to the hydrophobicity of PDG, it was-loaded into several nanocarriers such as; grafted β-cyclodextrin, chitosan magnetic NPs, chitosan nanospheres, selenium NPs and β-casein coated lactoferrin NPs 39 – 42 . It was also-loaded in implantable biomedical device made from poly-di-methyl-siloxane (PDMS) which contains thermosensitive Poly( N -isopropylacrylamide) and it was also-loaded into hybrid nanofiber made from poly( d,l -lactic-co-glycolic acid) (PLGA) with gelatin or Pluronic F127 for local management of triple negative breast cancer cell line 43 , 44 .…”

Section: Introductionmentioning

confidence: 99%

Prodigiosin/celecoxib-loaded into zein/sodium caseinate nanoparticles as a potential therapy for triple negative breast cancer

Mohamed,

El-Nekhily,

Mahmoud

et al. 2024

Sci Rep

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Nowadays, breast cancer is considered one of the most upsetting malignancies among females. Encapsulation of celecoxib (CXB) and prodigiosin (PDG) into zein/sodium caseinate nanoparticles (NPs) produce homogenous and spherical nanoparticles with good encapsulation efficiencies (EE %) and bioavailability. In vitro cytotoxicity study conducted on human breast cancer MDA-MB-231 cell lines revealed that there was a significant decline in the IC50 for encapsulated drugs when compared to each drug alone or their free combination. In addition, results demonstrated that there is a synergism between CXB and PDG as their combination indices were 0.62251 and 0.15493, respectively. Moreover, results of scratch wound healing assay revealed enhanced antimigratory effect of free drugs and fabricated NPs in comparison to untreated cells. Furthermore, In vitro results manifested that formulated nanoparticles exhibited induction of apoptosis associated with reduced angiogenesis, proliferation, and inflammation. In conclusion, nanoencapsulation of multiple drugs into nanoparticles might be a promising approach to develop new therapies for the managing of triple negative breast cancer.

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Anticolitic activity of prodigiosin loaded with selenium nanoparticles on acetic acid–induced colitis in rats

Cited by 11 publications

References 57 publications

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

Recent advances in the therapeutic applications of selenium nanoparticles

Prodigiosin/celecoxib-loaded into zein/sodium caseinate nanoparticles as a potential therapy for triple negative breast cancer

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