1982
DOI: 10.1111/j.1476-5381.1982.tb09327.x
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Anticonvulsant Actions of the Putative Γ‐aminobutyric Acid (Gaba)‐mimetic, Ethylenediamine

Abstract: Ethylenediamine, 31.6–1000 mg/kg intraperitoneally, inhibited the convulsive effects of pentylenetetrazol, 100 mg/kg (i.p.) in mice. Ethylenediamine, 100–1000 mg/kg (i.p.) increased the convulsion threshold to the intravenous infusion of three convulsants in the order pentylenetetrazol > bicuculline > strychnine. The benzodiazepine antagonist Ro15–1788, 10 mg/kg (i.p.), significantly inhibited the anticonvulsant action of diazepam, 50 μg/kg, but not ethylenediamine, 1000 mg/kg. These results clearly indicate t… Show more

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Cited by 12 publications
(1 citation statement)
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“…Also, as can be seen from Table 2, administration of GABA or amino-oxyacetic acid (AOAA) a GABA-transaminase inhibitor which has been shown to produce rapid accumulation of GABA in both whole brain and cerebellum (Biswas & Carls-son, 1978;Pagliusi et al, 1983), failed to affect either M2 or M3. Similarly, muscimol, a GABA-receptor agonist which protects against some chemically-induced seizures (DeFeudis, 1980;Meldrum, 1981), and ethylene diamine, a GABA-mimetic which antagonizes a number of other convulsants (Perkins et al, 1981;Morgan & Stone, 1982), were also without effect. The possibility that catechol might produce convulsions by interacting with benzodiazepine receptors, in a similar way to Ro-5-4864 (File et al, 1984) was eliminated by the lack of effect of Ro-151788, a selective benzodiazepine-receptor antagonist (Nutt et al, 1982).…”
Section: Discussionmentioning
confidence: 99%
“…Also, as can be seen from Table 2, administration of GABA or amino-oxyacetic acid (AOAA) a GABA-transaminase inhibitor which has been shown to produce rapid accumulation of GABA in both whole brain and cerebellum (Biswas & Carls-son, 1978;Pagliusi et al, 1983), failed to affect either M2 or M3. Similarly, muscimol, a GABA-receptor agonist which protects against some chemically-induced seizures (DeFeudis, 1980;Meldrum, 1981), and ethylene diamine, a GABA-mimetic which antagonizes a number of other convulsants (Perkins et al, 1981;Morgan & Stone, 1982), were also without effect. The possibility that catechol might produce convulsions by interacting with benzodiazepine receptors, in a similar way to Ro-5-4864 (File et al, 1984) was eliminated by the lack of effect of Ro-151788, a selective benzodiazepine-receptor antagonist (Nutt et al, 1982).…”
Section: Discussionmentioning
confidence: 99%