Anticonvulsant Activities of Crude Flavonoid Fraction of the Stem Bark of Ficus sycomorus (Moraceae)

Ibrahim, G.; Abdulmumin, Suleiman; Musa, K. Y.; Yaro, Alpha Seydou

doi:10.3923/jpt.2008.351.356

Cited by 23 publications

(16 citation statements)

References 3 publications

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“…The absence of monossacharides is relative to its absence in the compounds containing glycosides and thus might not enhance antibacterial activity in this extract. These metabolites are similar to those found in F. sycomorus (Victor, 2006;Ibrahim et al, 2008); except for anthraquinones which is found in this species. These classes (such as alkaloids, saponins, tannins, anthraquinones, and flavonoids) of compounds are known to have curative activity against several pathogens and therefore could suggest the use traditionally for the treatment of various illnesses (Hassan et al, 2004;Usman and Osuji, 2007).…”

Section: Discussionsupporting

confidence: 84%

Qualitative phytochemical screening and in vitro antimicrobial effects of methanol stem bark extract of Ficus thonningii (Moraceae)

Usman¹,

Abdulrahman²,

Usman³

2010

Afr. J. Trad. Compl. Alt. Med.

119

116

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The methanolic stem bark extract of Ficus thonningii (Moraceae) was subjected to preliminary phytochemical screening and in vitro antimicrobial tests. The phytochemical tests was carried out using standard methods of analysis and these investigations revealed the presence of alkaloids, anthraquinones, carbohydrates, flavonoids, saponins and tannins. The antimicrobial activity of the plant extract was assayed using the agar plate disc diffusion and nutrient broth dilution techniques. Test micro organisms were: Escherichia coli, Klebsiella spp, Pseudomonas aeruginosa, Salmonella typhi (Gram-negative), Staphylococcus aureus and Streptococcus spp. (Grampositive). The extracts inhibited the growth of all the test organisms at different concentrations especially againstPseudomonas aeruginosa and Streptococcus spp. which had mean inhibition zone of 33.33±7.33 mm and 32.33±2.51 mm respectively. The results showed the MIC of 10 mg ml -1 against pseudomonas and 1.25 against remaining organisms tested. The MBC against Staphylococcus aureus was 2.5 mg ml -1 and that of Streptococcus spp. was found to be 0.625mg ml -1 . The extracts showed varied inhibitory activity against the organisms studied.

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Section: Discussionsupporting

confidence: 84%

Qualitative phytochemical screening and in vitro antimicrobial effects of methanol stem bark extract of Ficus thonningii (Moraceae)

Usman¹,

Abdulrahman²,

Usman³

2010

Afr. J. Trad. Compl. Alt. Med.

119

116

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“…The MES is a standard procedure that evaluates the ability of the testing materials to protect against HLTE. Ibrahim et al [16] stated that the seizure features in MES are similar for all laboratory animals and human except for the time scale. The standard drug diazepam (7.5 mg/kg) and the ethanolic extracts of C. intybus (250 and 500 mg/ kg) and T. serotinum (500 mg/ kg) exhibited significant anticonvulsant activity and offered 80, 60, 70, and 50 % protection against electroshockinduced HLTE, respectively.…”

Section: Discussionmentioning

confidence: 99%

Potential Anticonvulsant Activity of Ethanol Extracts of Cichorium intybus and Taraxacum serotinum in Rats

Abdel-Rahman¹,

Soliman²,

Yusufoğlu³

et al. 2015

Trop. J. Pharm Res

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“…Abu Safieh et al (1986), Mimaki et al (1997) and Muazu and Kaita (2008) from their various studies, have shown the anticonvulsant effect of alkaloids. Fwthermore, flavonoids have also been shown to have anticonvulsant effect (Ibrahim et al, 2008;Van Heerden et al, 2002). According to the studies of Singh et al (2012) and Chauhan et al (1988), saponin and triterpene steroids also have anticonvulsant effects.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Gamma Aminobutyric Acid in the Anticonvulsant Effect of the Leaf Methanol Extract of Ruta graveolens L. (Rutaceae) in Mice

Ahmad¹,

Amabeoku²

2013

International J. of Pharmacology

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Abstract:The possible involvement of gamma aminobutyric acid (GABA), in the anticonvulsant effect of Ruta graveolens L. was investigated by studying the effect of the leaf methanol extract against seizures elicited by either pentylenetetrazole (PTZ), bicuculline, picrotoxin or N-Methyl-DL-Aspartic acid (NlvIDLA) in mice. Leaf methanol extract of Ruta graveolens, phenobarbitone, diazepam and muscimol significantly antagonized seizures induced by PTZ, bicuculline or picrotoxin. Combined treatment of sub-effective doses of R. graveolens and muscimol significantly antagonized seizures induced by PTZ, bicuculline or picrotoxin. Dimethylsulfoxide (DMSO) or phenytoin did not significantly affect the seizures produced by PTZ, bicuculline or picrotoxin. Ruta graveolens, phenobarbitone, diazepam, phenytoin or DMSO did not significantly affect seizures produced by NlvIDLA. LY233053 significantly antagonized seizures produced by NlvIDLA. Combined treatment of sub-effective doses of LY233053 and Ruta graveolens did not significantly alter NlvIDLA-induced seizures. The phytochemical qualitative analysis of the plant species showed the presence of tannins, cardiac glycosides, saponins, flavonoids, triterpene steroids and alkaloids. The LD50 value obtained following oral administration of the leaf methanol extract of R. graveolens was above 4000 mg kg-1 . The HPLC fingerprint of the plant species revealed certain characteristic peaks at 350 run. The data obtained in this study, indicate that the leaf methanol extract of R. graveolens has anticonvulsant activity. The data obtained also indicate that GABA mechanism may probably be involved in the anticonvulsant effect of the plant extract. The relatively high LD50 obtained for the plant species, given orally, indicates that it is safe in mice. IntroductionEpilepsy is a worldwide neurological disorder which 1s also prevalent in South Africa. Besides the use of standard medicines to manage and treat the condition effectively, medicinal plants have been used especially in rural commmrities by traditional medicine practitioners to manage and treat epilepsy (Van Wyk et al., 1997; Wat 1967). One of such medicinal plants is Ruta graveolens L.

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Anticonvulsant Activities of Crude Flavonoid Fraction of the Stem Bark of Ficus sycomorus (Moraceae)

Cited by 23 publications

References 3 publications

Qualitative phytochemical screening and in vitro antimicrobial effects of methanol stem bark extract of <i>Ficus thonningii</i> (Moraceae)

Qualitative phytochemical screening and in vitro antimicrobial effects of methanol stem bark extract of <i>Ficus thonningii</i> (Moraceae)

Potential Anticonvulsant Activity of Ethanol Extracts of <i>Cichorium intybus</i> and <i>Taraxacum serotinum </i>in Rats

Involvement of Gamma Aminobutyric Acid in the Anticonvulsant Effect of the Leaf Methanol Extract of Ruta graveolens L. (Rutaceae) in Mice

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