Anticonvulsant activities of myo-inositol and scyllo-inositol on pentylenetetrazol induced seizures

Abstract

Myo-inositol (MI) and its isomers are used for the treatment of various neuropathological conditions. The purpose of the present research was to study anticonvulsant properties of MI and scyllo-inositol (SCI) on pentylenetetrazol (PTZ) induced seizures in rats. Half an hour after treatment with MI (30 mg/kg) or SCI (5 mg/kg) seizures were induced in Wistar rats with PTZ (60 mg/kg). Control animals were treated either by normal saline or mannitol (control polyol of the same molecular weight, 30 mg/kg), given at the same time interval before PTZ injection, as MI/SCI groups. The anticonvulsant effects of MI/SCI treatment were assessed by the latent period (the time from PTZ-injection to the onset of first seizures), and the duration and severity (score) of seizures. The mortality rate was also assessed. Both MI and SCI treatment significantly reduced the seizure score, seizure duration and increased the latent period. These data suggest for strong potential of MI and SCI as the agents of antiepileptic therapy.

Myoinositol Attenuates the Cell Loss and Biochemical Changes Induced by Kainic Acid Status Epilepticus

“…MI is characterized by anticonvulsant properties and this inositol could partially reduce the seizure grade and duration of PTZ or KA induced convulsions [7, 8]. The influence of inositol on molecular changes after SE could be simply mediated by antiseizure activity of compound and/or its action on GABA-A receptors.…”

“…In later studies we revealed that MI pretreatment significantly decreases the severity of seizures induced either by pentylenetetrazole (PTZ) or by kainic acid (KA) [7, 8]. In the next series of experiments initially we induced the status epilepticus (SE) by KA and then tried MI daily treatment.…”

“…MI significantly reduces the seizure score and seizure duration of KA and PTZ induced convulsions [7, 8] and also inhibits 3 H-muscimol binding to GABA-A receptors in vitro [4]. Thus it is possible that MI effects on biochemical processes of epileptogenesis, observed in our previous experiments [9, 10], were mediated by its action on GABA-A receptors and/or anticonvulsant properties of MI, other than its action on GABA-A receptors.…”

Brain tumour-associated status epilepticus

“…Importantly, Solomonia et al showed that MI significantly reduced the intensity and severity of seizures [58]. Importantly, Nozadze et al also demonstrated that MI delayed the latent period for seizure onset and decreased seizure duration [59]. Thus, unlike all other mechanisms discussed in this section (which emphasize excitatory/inhibitory imbalances), MI levels address the oftenignored area of the refractory period in favouring TAE over TASE.…”

The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances inmyo‐Inositol Chemistry)

“…[71] In rats seizures induced by pentylenetetrazole were reduced in severity following the administration of scyllo-inositol, suggesting that it may have a role to play in antiepileptic therapy. [72] …”