Anticonvulsant activity of aqueous root extract of Ficus religiosa

Role of saponins for the anticonvulsant effect of adventitious roots ofFicus religiosa

“…Magnesium has been found to suppress convulsions induced through glutamatergic mechanisms, but not through GABAergic mechanisms, when investigated in experimental animal models (Decollogne et al, 1997). But, effectiveness of the adventitious root extract in PTZ test in our study, and in PTZ and picrotoxin (GABA A antagonists) test in the study of Patil et al (2011) indicated the involvement of some other phytoconstituent(s) along with magnesium for its activity. So, to find out the active anticonvulsant fraction, the extract was fractionated by polarity-based liquidliquid partitioning.…”

“…The investigator suggested the traces of magnesium and zinc present in the root extract to be responsible for its anticonvulsant effect (Patil et al, 2011). The speculation of the authors regarding the role of trace elements for the activity is not much convincing.…”

“…In spite of its wide ethnomedicinal use, only a few experimentally validated reports substantiating the use of adventitious roots are available in literature. Even the phytochemical studies carried out on the adventitious roots is limited to identification of phenolic substances, trace amount of amino acids, proteins, and trace elements (Patil et al, 2011;Sharma & Gupta, 2007). Since its adventitious roots have been clinically used for the treatment of epilepsy, only a single study carried out on the crude adventitious root extract is available (Patil et al, 2011).…”

“…Even the phytochemical studies carried out on the adventitious roots is limited to identification of phenolic substances, trace amount of amino acids, proteins, and trace elements (Patil et al, 2011;Sharma & Gupta, 2007). Since its adventitious roots have been clinically used for the treatment of epilepsy, only a single study carried out on the crude adventitious root extract is available (Patil et al, 2011). Our continued interest in exploring this plant for CNS activities led us to undertake the present study.…”

Anti-ulcer activity of Medicinal Herbs - A Review

“…Doob grass herb contains flavonoids. The alcoholic extract showed the presence of flavanoids, which is supposed to be responsible for antiulcer property [39,40,41] . The alcoholic extract inhibited ulceration by inhibiting output volume and total acidity.…”