Anticonvulsant activity of Bacopa monniera in rodents

Kaushik, Darpan; Tripathi, Ashish Kumar; Tripathi, Rashmi; Ganachari, M. S.; Khan, Shahrukh Rafi

doi:10.1590/s1984-82502009000400006

Cited by 23 publications

(15 citation statements)

References 4 publications

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“…Bacopa monnieri plant is reported for anxiety, depressant, epilepsy, and Parkinsonism and contains alkaloids (Brahmin, nicotine, herpestine, and bacosides A & B), saponins (hersaponin and monnierin), flavonoids (luteolin and apigenin), and sterols like b-sitosterol and stigma-sterol. These constituents are already reported for such neuropharmacological properties and so might be responsible for said activities of this plant [33][34][35][36].…”

Section: Resultsmentioning

confidence: 81%

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

Khan

Shah

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Almost every region of Pakistan is stacked with a large number of medicinal plants. Due to high cost and unavailability of allopathic medicines for the neurological diseases, especially in rural areas, traditional healers prescribe phytotherapy for various neurological diseases like epilepsy, depression, anxiety, insomnia, Alzheimer, and migraine. Such treatments are considered to be most effective by the native people. Methods. The data was collected from articles published on medicinal plants of various districts of Pakistan, using article search engines like Medline, Pubmed, Web of Science, Science Direct, and Google Scholar. Also, information regarding various neurological uses and mode of applications of medicinal plants was obtained from traditional healers, folk medicine users, and local elderly people having knowledge of medicinal plants. Results. A total of 54 families were found to be used in various neurological diseases, of which the highest use was of Solanaceae (22.22%), Asteraceae (12.96%), Lamiaceae, Papaveraceae, and Poaceae, 9% each, and Caprifoliaceae, Cucurbitaceae, Rhamnaceae, and Rosaceae, 5.5% each. According to districts, 15% of plants that were effective in neurological affections were found in Bahawalpur, 11% in Swat, 8% in Muzaffarabad, 7% in Malakand, and 6% in Bahawalnagar, Dir, Gilgat, and Sarghoda each, with 5% in Dera ghazi khan and Jhelum each. According to the plant’s habit, out of total of 103 plants, 61.15% were found to be herbs, 22.33% trees, 11.65% shrubs, and 4.85% climbers. According to the part used of plant, whole plant, leaves, fruits, roots, seeds, and flowers were found to be used 32.03%, 24.27%, 20.38%, 16.50%, 13.59%, and 11.65%, respectively. According to disease’s types, 45.63% were found to be effective in insomnia, 31.06% in epilepsy 12.62% in depression, 6.80% in anxiety, 7.77% in hysteria, and 5.88% in migraine. Conclusion. Taking into consideration this useful knowledge on medicinal properties of the plants for curing neurologic diseases, it is believed that research in areas of ethnomedicine and ethnopharmacology can bring auspicious results that have potential of adding value to the very rich natural resources of Pakistan. This study will help all the researchers from diverse backgrounds working on plants based medicine for neurological diseases.

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Section: Resultsmentioning

confidence: 81%

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

Khan

Shah

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Several, medicinal plants including Bacopa monnieri have been studied for anticonvulsant activity 38 . The ethanolic extract of Bacopa monnieri leaves administered at 50 mg/kg orally produced significant anticonvulsant activity for all the different models studied with a mechanism of action similar to that of benzodiazepines (GABA agonist) 39 . The anticonvulsant activity of two polyherbal formulations of B. monnieri, i.e.…”

Section: Anti-depressant and Anti-anxiety Activitymentioning

confidence: 90%

Untitled

2019

IJPSR

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In recent times, the use of herbal products has increased tremendously in the developing as well as in developed countries. Bacopa monnieri is one of the most important medicinal plant that has been consumed for thousands of year as a memory enhancing, anti-inflammatory, analgesic, antipyretic, sedative and anti-epileptic agent. For many years, a lot of commercial and medicinal researches have been focusing their resources on this plant. The plant has been known to possess various activities such as, antibacterial, anti-fungal, anti-cancer, anti-oxidant, anti-inflammatory, antihyperglycemic, anti-depressant, anti-epileptic, memory enhancer, anti-ulcer, hepatoprotective, analgesic, anti-diarrheal, anti-hypertensive, anti-toxicity etc. Therefore step should be taken for its sustainable use and conservation. This review describes the phytoconstituents, traditional uses, and pharmacological activities of Bacopa monnieri. In brief, the biotechnological applications such as tissue culture, elicitation, genetic transformation for the advancement of this plant and its active components production have also been described. Habitat, Geographical Distribution, and Ethnomedical Description: Bacopa monnieri is a perennial, creeping herb whose habitat includes wetlands and muddy shores. The leaves are succulent, relatively thick, oblanceolate and are

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“…In a study conducted on Bacopa monniera leaves, mechanism elucidated for anticonvulsant action was GABA agonist action. 23 In comparative terms, it may be concluded that anticonvulsant activity of three different extracts were found in dose dependent manner. The least activity was recorded for acetone extract whereas ethanolic extract exhibited maximum anticonvulsive potential.…”

Section: Pharmacological Screeningmentioning

confidence: 98%

Pharmacognostic, physicochemical and phytochemical investigation of Bacopa monnieri L. stem and its anticonvulsant potential in laboratory animals

Mishra

PrakashTiwari

et al. 2015

International Journal of Epilepsy

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Aim The aim of present work was to study the pharmacognostic standardization, physicochemical, phytochemical and pharmacological evaluation of the stem of Bacopa monnieri L. Method Standard method was followed for pharmacognostic, physicochemical, and phytochemical study. For quantitative analysis, HPTLC technique was employed. Maximal electroconvulsive shock (MES) and pentylenetetrazole (PTZ) method was used for anticonvulsant evaluation. Result Microscopic study of the stem showed presence of epidermis and cortex having large intercellular spaces. The oval shaped starch grains were present in cells of cortex and endodermis. Total ash (5.98%), water-soluble ash (4.91%), acid-insoluble ash (3.96%), water soluble extractive (15.31%) and ethanol soluble extractive (6.74%) values were evaluated for physicochemical evaluations. Quantitative estimation of Bacoside A (marker compound) by HPTLC technique was performed. The linearity (100–600 ng), the % recovery (97.81% w/w) were estimated. The Bacoside A in the alcoholic extract was found to be higher than that of the other extracts. The proposed HPTLC method was found to be simple and accurate. The anticonvulsant activities of all the extracts were evaluated by MES and PTZ models in mice. Conclusion The least anticonvulsant potential was recorded for acetone extract in dose of 100 mg/kg and maximum anticonvulsant action was recorded for ethanolic extract in dose of 300 mg/kg.

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Anticonvulsant activity of Bacopa monniera in rodents

Cited by 23 publications

References 4 publications

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

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Pharmacognostic, physicochemical and phytochemical investigation of Bacopa monnieri L. stem and its anticonvulsant potential in laboratory animals

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