Anticonvulsant Activity of Carissa carandas Linn. Root Extract in Experimental Mice

Hegde, Karunakar; Thakker, Shalin P.; Joshi, Arun B.; Shastry, C. S.; Chandrashekhar, KS

doi:10.4314/tjpr.v8i2.44519

Cited by 56 publications

(49 citation statements)

References 24 publications

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“…There are many antiepileptic drugs presently in clinical use like phenytoin, carbamazepine, Ethosuximide, phenobarbitone and clonazepam 2,4 . The current therapy of epilepsy with modern antiepileptic drugs is associated with side effects , dose related and chronic toxicity and teratogenicity 5 , and around 30% of the patients continue to have seizures with current antiepileptic drugs 3,6 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Mudawi

El-wahab

Yassin

et al. 2017

AJPRHC

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In Kingdom of Saudi Arabia Achillea fragrantissima is a fragrant, perennial herb has long been used medicinally for its analgesic properties among Rafha residents. The present study concluded that Achillea fragrantissima (Gaisoom) possess a potent anticonvulsant activity against PTZ induced seizures which may be due to GABAA agonistic activity and /or antioxidant activity. The results of the current study showed that the ethanolic extract of Gaisoom at doses of 300 mg/kg and 600 mg/kg has anticonvulsant activity in pentylenetetrazole and maximum electroshock induced seizures models on mice. The Hexane extract have protected the mice against pentylenetetrazole -induced seizures with 100% protection rate and 100% animal survival similar to the anticonvulsant drug phenobarbital. HPLC-DAD fingerprints of different fractions were also carried out to find the pharmacological active compound. The studies are in progress to isolate the compounds by HPLC technique. Supplementary studies are required to explain the exact mechanism of action by which Gaisoom act as an anticonvulsant agent.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Mudawi

El-wahab

Yassin

et al. 2017

AJPRHC

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show abstract

“…The decrease in plasma glucose and Ca 2+ during and after convulsion recorded in this research has been reported by Hegde et al (2009) in mice treated with root extract of Carissa carandas Linn. The circulatory level of glucose decreases during convulsion in order to meet the energy demand of the process (Rogawski and Loscher, 2004).…”

Section: Resultsmentioning

confidence: 76%

Anticonvulsant and Analgesic Properties of Leaf and Root Extracts of Newbouldia laevis

Agbafor¹,

Ezeali²,

Akubugwo³

2015

Asian J. of Biochemistry

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Extracts of various parts of Newbouldia laevis are used traditionally in Eastern Nigeria in management and treatment of several diseases, including some neurological disorders. This study investigated anticonvulsant and analgesic potentials of leaf and root extracts. The extracts were prepared with deionized water and ethylacetate. Extracts doses of 200, 400, 600 and 800 mg kgG 1 b.wt. were used for the investigations. Anticonvulsant potential of the extracts against pentylenetetrazole-induced convulsion was tested in albino rats, by measuring time for convulsion onset, duration of convulsion and plasma glucose and Ca 2+ levels before, during and after convulsion, using diazepam as standard. The hot plate method was used to investigate the analgesic property of the extracts using morphine sulphate as standard. Pretreatment of the animals with different doses of the extracts delayed the onset of convulsion in a dose-dependent manner. Convulsion was not observed in 800 mg kgG 1 b.wt. of Deionized Water Leaf (DWL) extract and in diazepam pretreated groups. The extracts decreased significantly (p<0.05) the severity of convulsion and prolonged the duration of convulsion induced by pentylenetetrazole. The plasma concentration of glucose and Ca 2+ decreased significantly (p<0.05) in the test groups through the course of convulsion, while they did not change significantly (p>0.05) in the non-convulsed groups.All the extracts at all doses and 4 mg kgG 1 of morphine sulphate (an analgesic) showed a significant (p<0.05) percentage inhibition against hot plate induced pain. The difference between the analgesic potentials of 800 mg kgG 1 of DWL extract and 4 mg kgG 1 morphine sulphate was not significant (p>0.05). These findings indicate that the extracts may be effective in management/treatment of convulsion and pains.

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“…Finally, the percentage inhibition of seizures, relative to the control, was calculated at various doses of the extract and fractions. All the anticonvulsant agents have the ability to shorten or abolish the extensor phase of convulsions (Kulkarni 1999;Vogel 2002;Ya'u et al 2008;Hegde et al 2009;Tripathi et al 2011;Bhandari et al 2013). …”

Section: Anticonvulsant Activitymentioning

confidence: 99%

Bioactive non-sterol triterpenoid fromStreblus asper: microwave-assisted extraction, HPTLC profiling, computational studies and neuro-pharmacological evaluation in BALB/c mice

Verma

Tripathi

Saraf

2016

Pharmaceutical Biology

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Context: In folk medicine, the stem bark of Streblus asper Lour. (Moraceae) has been reported to possess anticonvulsant activity. However, no systematic/scientific validation is available. Objective This study explores the constituents in the stem bark, their biosassy-guided isolation and their efficacy in neuro-pharmacological disorders, for validating the traditional claims. Materials and methods: Microwave-assisted extraction (MAE) technique was employed to obtain the crude extract. The n-hexane, dichloromethane and aqueous fractions were prepared and phytoconstituents were ascertained by phytochemical tests. The isolated compound, betulin, was characterized by different physicochemical and spectral methods, including HPTLC. Finally, neuro-pharmacological evaluations were conducted at 100, 200, 400 mg/kg b.w., p.o. (25, 50, 100 mg/kg b.w. for betulin) doses in BALB/c mice. Results: The n-hexane fraction (400 mg/kg), and isolated compound betulin (100 mg/kg), showed maximum anticonvulsant activity in maximal electroshock (87.84% and 85.14% seizure inhibition), and isoniazid induced convulsion models (88.85% and 83.18% seizure inhibition), respectively. A dose-dependent attenuation of epileptic seizures was observed, probably through GABArgic mechanism of anticonvulsant action. Moreover, the antidepressant study was also conducted using behavioural models and the results expound that n-hexane and dichloromethane fractions (400 mg/kg) significantly reduced the duration of immobility, as compared to the control. Discussion and conclusion: This study reports some novel aspects like applying an environmentally benign/green approach of MAE, neuro-pharmacological screening and use of docking studies, for the first time, on the plant S. asper. The findings present a rational explanation for its use in traditional medicine, for the management of neuro-pharmacological disorders.ARTICLE HISTORY

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Anticonvulsant Activity of Carissa carandas Linn. Root Extract in Experimental Mice

Cited by 56 publications

References 24 publications

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Evaluation of Anticonvulsant Activity and HPLC–DAD Profiling of <i>Achillea fragrantissima</i> (Gaisoom) Extracts Growing in Saudi Arabia

Anticonvulsant and Analgesic Properties of Leaf and Root Extracts of Newbouldia laevis

Bioactive non-sterol triterpenoid fromStreblus asper: microwave-assisted extraction, HPTLC profiling, computational studies and neuro-pharmacological evaluation in BALB/c mice

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