Anticonvulsant activity of Iranian medicinal plants and molecular docking studies of isolated phytochemicals

Zadali, Reza; Baghery, Mohsen; Abbasi, Mehrshad; Yavari, Niksa; Miran, Mansour; Ebrahimi, Samad Nejad

doi:10.1016/j.sajb.2022.06.044

Cited by 7 publications

(1 citation statement)

References 65 publications

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“…(Kaur et al, 2021;He et al, 2023). It has been reported that numerous phytochemicals isolated from plants have promising potential to reach various drug targets in epileptic animal models (Chipiti et al, 2021;Subedi and Gaire, 2021;Zadali et al, 2022;Carreño-González et al, 2023). These phytochemicals can interact with different types of receptors in the central nervous system (CNS), such as N-methyl-D-aspartate receptor (NMDAR), Gamma-aminobutyric acid receptor (GABAAR), and α-amino-3hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), channels like voltage gated sodium, potassium, and calcium channels, and other enzymes and pathways that play a significant role in the initiation and propagation of epileptic seizures.…”

Section: Introductionmentioning

confidence: 99%

Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

Waris,

Ullah,

Asim

et al. 2024

Front. Pharmacol.

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Epilepsy is one of the most common, severe, chronic, potentially life-shortening neurological disorders, characterized by a persisting predisposition to generate seizures. It affects more than 60 million individuals globally, which is one of the major burdens in seizure-related mortality, comorbidities, disabilities, and cost. Different treatment options have been used for the management of epilepsy. More than 30 drugs have been approved by the US FDA against epilepsy. However, one-quarter of epileptic individuals still show resistance to the current medications. About 90% of individuals in low and middle-income countries do not have access to the current medication. In these countries, plant extracts have been used to treat various diseases, including epilepsy. These medicinal plants have high therapeutic value and contain valuable phytochemicals with diverse biomedical applications. Epilepsy is a multifactorial disease, and therefore, multitarget approaches such as plant extracts or extracted phytochemicals are needed, which can target multiple pathways. Numerous plant extracts and phytochemicals have been shown to treat epilepsy in various animal models by targeting various receptors, enzymes, and metabolic pathways. These extracts and phytochemicals could be used for the treatment of epilepsy in humans in the future; however, further research is needed to study the exact mechanism of action, toxicity, and dosage to reduce their side effects. In this narrative review, we comprehensively summarized the extracts of various plant species and purified phytochemicals isolated from plants, their targets and mechanism of action, and dosage used in various animal models against epilepsy.

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Section: Introductionmentioning

confidence: 99%

Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

Waris,

Ullah,

Asim

et al. 2024

Front. Pharmacol.

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A review on pharmaceutical pollutants removal in water solution by catalytic ozonation using zeolite

Bavianne,

Jing,

Auriol

et al. 2024

Can J Chem Eng

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The presence of pharmaceutical pollutants in water sources constitute a serious risk to human health and the environment. Catalytic ozonation has emerged as a promising strategy for reducing these pollutants. This procedure uses ozone with the help of catalysts to improve the oxidation of organic molecules. Recently, there has been a lot of interest in using zeolite as an ozonation catalyst in the elimination of pharmaceutical contaminants from water solutions. Zeolites have unique properties such as their high surface area, porosity, and ion‐exchange capabilities, that make them effective catalysts for the decomposition of ozone and the oxidation of organic pollutants into harmless byproducts. This study aims to investigate the efficiency of zeolite catalytic ozonation in the elimination of pharmaceutical pollutants from aqueous solutions encompassing the working mechanisms, the determinants affecting the process's efficiency, potential obstacles, and perspective avenues for advancement within this field.

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Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants

Abd-Allah,

Abd El-Maksoud,

Elbaset

et al. 2023

Med Chem Res

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Aiming to develop novel anticonvulsant agents a new series of novel cycloalkanecarboxamide parabanic acid hybrids series 8, 9 and 10 possessing the essential structure requirements for anticonvulsant activity was synthesized starting from cycloalkanones. All final target compounds were primary screened for chemically and electrically induced seizures using pentylenetetrazole “scPTZ” and maximal electroshock seizure “MES” models. In phase I anticonvulsant evaluation compounds 8b and 10b exhibited the highest potency among all the target compounds with 100% protection towards chemically induced seizures. Results of phase II anticonvulsant screening showed that compounds 8b and 10b are more potent than standard drug ethosuximide by about 11 and 9 fold, respectively. Regarding MES test, compounds 8b and 9a-d exhibited 100% protection with ED50 values ranged between 0.107–0.177 mmol/Kg. All final compounds did not display any signs of motor impairment in the neurotoxicity screening test. Also, compounds 8a, 9a-d and 10b were devoid of hepatotoxicity as shown by measurement of serum levels of liver enzymes, albumin as well as total protein. Moreover, the cyclohexyl derivative 10b produced a significant increase of Gamma-aminobutyric acid “GABA” brain’s content of mice compared to control group confirmed its GABAergic modulating activity. Molecular docking, physicochemical and pharmacokinetic properties were carried out for all compounds as well. These outcomes support that cycloalkanecarboxamide parabanic acid hybrid is a promising scaffold to pave the way towards further development of novel class of antiepileptic drugs.

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Anticonvulsant activity of Iranian medicinal plants and molecular docking studies of isolated phytochemicals

Cited by 7 publications

References 65 publications

Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

A review on pharmaceutical pollutants removal in water solution by catalytic ozonation using zeolite

Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants

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