Anticonvulsant activity of Mimosa pudica decoction

Bum, Elisabeth Ngo; Dawack, D.L; Schmutz, M.; Rakotonirina, A.; Rakotonirina, S.V.; Portet, C.; Jeker, A.; Olpe, H.-R.; Herrling, Paul L.

doi:10.1016/j.fitote.2004.01.012

Cited by 75 publications

(13 citation statements)

References 7 publications

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“…As the prevalence of asthma increases around the world, we need to develop an effective therapeutic drug for asthma. Mp belongs to the Mimosaceae family and has been used traditionally as a therapeutic agent for various diseases (Ngo Bum et al , 2004; Amalraj and Ignacimuthu, 2002). However, the effect of Mp extract on asthma is not yet well known.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, Mimosa pudica (Mp), an annual or a perennial plant known as a sensitive plant, belongs to the Mimosaceae family. M. pudica has been used traditionally as a medicine for insomnia, gastroenteritis and inflammation in many countries; however, the exact effect of Mp extract on allergic disease such as asthma has not yet been investigated (Ngo Bum et al , 2004; Amalraj and Ignacimuthu, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of New Iridium Photosensitizers for Catalytic Hydrogen Generation from Water

Gärtner

Denurra

Losse

et al. 2012

Chemistry A European J

108

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Novel phenylazole ligands were applied successfully in the synthesis of cyclometalated iridium(III) complexes of the general formula [Ir(phenylazole)(2)(bpy)]PF(6) (bpy=2,2'-bipyridine). All complexes were fully characterized by NMR, IR, and MS spectroscopic studies as well as by cyclic voltammetry. Three crystal structures obtained by X-ray analysis complemented the spectroscopic investigations. The excited-state lifetimes of the iridium complexes were determined and showed to be in the range of several hundred ns to multiple µs. All obtained iridium complexes were active as photosensitizers in catalytic hydrogen evolution from water in the presence of triethylamine as a sacrificial reducing agent. Applying an in situ formed iron-based water reduction catalyst derived from [HNEt(3)](+) [HFe(3)(CO)(11)](-) and tris[3,5-tris-(trifluoromethyl)-phenyl]phosphine as the ligand, [Ir(2-phenylbenz-oxazole)(2)-(bpy)]PF(6) proved to be the most efficient complex giving a quantum yield of 16% at 440 nm light irradiation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of New Iridium Photosensitizers for Catalytic Hydrogen Generation from Water

Gärtner

Denurra

Losse

et al. 2012

Chemistry A European J

108

View full text Add to dashboard Cite

show abstract

“…[24] Inhibitions of inducible MES seizures or PTZ induced seizure by a PHF reported in the present study validates the persistent use of the formulation in the convulsive disorders. [15] Thus, chemical constituents with anticonvulsant activity and probable utility in the control of generalized convulsive disorders in epileptic patients can be isolated from different plants of this formulation. PHF (200 and 400 mg/kg, p.o.)…”

Section: Discussionmentioning

confidence: 99%

“…[12] Indian traditional medicine system which offers many potential medicinal plants for epilepsy either in raw form or in the form of formulations. In Ayurveda, plants such as Embelia ribes ,[13] Bacopa monnieri , Ziziyphus nummularia , Cajanus cajan ,[14] Mimosa pudica ,[15] etc., have been suggested to be used to control epilepsy.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Screening of a Classical Ayurvedic Formulation for Anticonvulsant Activity

et al. 2016

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Background:Epilepsy is a serious and complex central nervous system disorder associated with recurrent episodes of convulsive seizures due to the imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmitters level in the brain. The available treatments are neither competent to control the seizures nor prevent progress of disease. Since ages, Herbal medicines have remained important sources of medicines in many parts of world which is evidenced through their uses in traditional systems of medicine i.e. Ayurveda, Siddha, Unani, Homeopathy and Chinese etc.Aim:A polyherbal formulation (containing Terminalia chebula Retz., Asparagus racemosus Willd., Embelia ribes Burm. F, Acorus calamus L., Tinospora cordifolia (Willd.) Miers, Convolvulus pluricaulis Choisy, Saussurea lappa C.B.Clarke, Achyranthes aspera L.) is mentioned in Ayurvedic classics Bhaiṣajya Ratnāvali. The aim of the study was to evaluate the anticonvulsant activity of the formulation in Maximum electroshock and Pentylenetetrazole induced convulsions in rats.Materials and Methods:In the present study, a polyherbal formulation was developed as directed by classical text and evaluated for the anticonvulsant activity using Maximal Electroshock Shock (MES) and Pentylenetetrazole (PTZ) induced convulsions in rats. Statistical comparison was done by one way ANOVA followed by the Tukey's multiple comparison test.Results:The obtained results showed that the PHF had a protective role on epilepsy. Treatment with PHF significantly improves antioxidant enzymes activities of superoxide dismutase (SOD) and glutathione (GSH) levels significantly as compared to controls. PHF also significantly decreased malonaldialdehyde (MDA) levels in the brain. Moreover, it also attenuated the PTZ-induced increase in the activity of GABA-T in the rat brain.Conclusion:These findings suggest that PHF might have possible efficacy in the treatment of epilepsy.

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“…Su importancia no es sólo agroalimentaria, las leguminosas también producen compuestos secundarios de interés farmacológico entre los que se encuentran alcaloides y aminoácidos no proteicos, isoflavonoides con actividad estrogé-nica, antiangiogénica, antioxidante y anti cancerígena; saponinas con actividad alelopática, antimicrobiana, insecticida, anticolesterolémica, anti inflamatoria, antialérgica y anti cancerígena (Aerts et al 1999, Setchell & Cassidy 1999, Alekel et al 2000, Dixon 2001, Dixon & Summer 2003. Específicamente, en algunas especies de la subfamilia Mimosoideae, se han caracterizado y extraído substancias con propiedades antibióticas, antitumorales, antiofídicas, antimaláricas, cicatrizantes y antivirales, entre otras (Arredondo et al 1998, Osman et al 2002, Gathuma et al 2004, Meckes et al 2004, Ngo-Bum et al 2004, Garavito et al 2006, Kukhetpitakwong et al 2006, Bouhlel et al 2007, Rivera-Arce et al 2007a, 2007b.…”

Section: Introductionunclassified

Usos medicinales de Prosopis juliflora (Sw.) DC. en comunidades rurales de la península de Paraguaná, Venezuela

Taisma¹

2017

Rev peru biol

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En este trabajo se proporciona información de los usos medicinales atribuidos a Prosopis juliflora (Sw.) DC. por habitantes de cinco localidades rurales de la Peninsula Paraguaná (Estado Falcon, Venezuela). Se realizaron entrevistas semi-estructuradas a 51 informantes, de entre 23 y 86 años de edad, naturales de la península de Paraguaná. Todos los entrevistados atribuyeron alguna propiedad curativa a hojas, frutos y/o tallos de P. juliflora. Los mayores porcentajes de uso medicinal de la especie se refirieron a patologías traumatológicas, oftalmológicas y de la función sexual masculina. Algunos otros usos medicinales reportados en menor proporción incluyen tratamientos para la diabetes, enfermedades del sistema digestivo, parasitosis, enfermedades eruptivas, coadyuvante en casos de malestar general, cálculos renales y cáncer. Los resultados constituyen la primera compilación de usos medicinales de P. juliflora en Venezuela, y permiten establecer bases para el desarrollo de investigaciones tendientes a la determinación de su prospección bioquímica y farmacológica.

show abstract

Anticonvulsant activity of Mimosa pudica decoction

Cited by 75 publications

References 7 publications

Synthesis and Characterization of New Iridium Photosensitizers for Catalytic Hydrogen Generation from Water

Synthesis and Characterization of New Iridium Photosensitizers for Catalytic Hydrogen Generation from Water

Preliminary Screening of a Classical Ayurvedic Formulation for Anticonvulsant Activity

Usos medicinales de Prosopis juliflora (Sw.) DC. en comunidades rurales de la península de Paraguaná, Venezuela

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