Anticonvulsant, analgesic and antipyretic activities of Taxus wallichiana Zucc.

Nisar, Muhammad; Khan, Inamullah; Simjee, Shabana Usman; Gilani, Anwarul Hassan; Obaidullah,; Perveen, Humera

doi:10.1016/j.jep.2007.12.021

Cited by 83 publications

(66 citation statements)

References 21 publications

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“…Various concentrations of T. wallichiana extract added to 2.5 ml of 0.2 M phosphate buffer (pH 6.6), and 2.5 ml of 1% potassium hexacyanoferrate [K 3 Fe (CN) 6 ]. The reaction mixture was incubated for 20 min at 50°C.…”

Section: Reducing Power Assaymentioning

confidence: 99%

“…It is a medium-sized evergreen tree attaining a height of 10-28 m. Its leaves are flat, dark green, and spirally arranged [2]. In Asia, it is distributed along Afghanistan through the Himalayas to the Philippines and is widely found in India and Pakistan.…”

Section: Introductionmentioning

confidence: 99%

“…Himalayan medicinal plants form important constituents of alternative medicinal systems such as Amchi, Ayurveda, Han Chinese, Unani, and other traditional medicine systems that are prevalent in this region. Existing literature on T. wallichiana shows its analgesic, antipyretic, anti-inflammatory, immunomodulatory, antiallergic, anticonvulsant, anticociceptive, antiosteoporotic, antibacterial, antifungal, antiplatelet, and antispasmodic activities, and vasorelaxing effect [2,[4][5][6][7]. In India, its leaves and bark are used in Unani drug "Zarnab" prescribed as a sedative, aphrodisiac and as cure for bronchitis, asthma, epilepsy, snake bite, and scorpion stings [3].…”

Section: Introductionmentioning

confidence: 99%

“…It is consumed as decoctions, herbal tea, and juice for treating cold, cough, respiratory infections, indigestion, and epilepsy. It is used locally on the infected wounds and burns [6,8].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Antioxidant Potential and Hepatoprotective Activity of Taxus Wallichiana

Bhat

Ganie

Dar

et al. 2018

Asian J Pharm Clin Res

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Objectives: Taxus wallichiana, the member of family Taxaceae is used for the cure of various ailments by a large ethnic population native to the forests in Kashmir valley. The aim of this study is to evaluate antioxidant potential and hepatoprotective action of T. wallichiana as claimed by the ethnic population segment.Methods: Antioxidant potential of different T. wallichiana extracts was evaluated by estimating the total phenolics, 1,1-diphenyl -2-picrylhydrazyl (DPPH), reducing power, microsomal lipid peroxidation (LPO), and hydroxyl radical scavenging activity through standard protocols. Hepatoprotective activity of T. wallichiana was determined by evaluation of liver marker enzyme (aspartate transaminase, alanine transaminase, and alkaline phosphatase) levels using standard protocols and by histological analysis of rat liver tissues of different animal groups against CCl 4 induced liver damage.Results: Phenolic content expressed as gallic acid equivalents (GAE/g) was found maximum in case of ethanolic extract (153.34 mg GAE/g), followed by extracts of methanol (149.24 mg GAE/g), hexane (134 mg GAE/g), ethyl acetate (128.9 mg GAE/g), chloroform (121.37 mg GAE/g), and aqueous (113.00 mg GAE/g). At concentration of 700 µg/ml, DPPH radical scavenging activity of methanol extract was 88.29% with IC 50 (212.00 µg/ml), aqueous (82.47%) with IC 50 (258.29 µg/ml), and ethyl acetate (79.57%) with IC 50 (301.80%µg/ml). The reducing power of the extracts increased in a concentration dependent manner. At concentration of 700 µg/ml, 79%, 68%, and 56% inhibition was observed with extracts of methanol, aqueous, and ethyl acetate on microsomal LPO with IC 50 values of 126.09, 168.83, and151.96 µg/ml, respectively. Superoxide radical scavenging activity of T. wallichiana extracts increased in a dose-dependent manner with IC 50 values 170.30 µg/ml (methanol), 257.00 µg/ml (aqueous), and 297.55 µg/ml ethyl acetate extract. T. wallichiana extracts exhibited antioxidant effects on calf thymus DNA damage. The results further depict the hepatoprotective action of T. wallichiana extract at doses of 100 and 300 mg/kg and were comparable with that of standard treatment comprising 50 mg/kg-day of Vitamin C, a known hepatoprotective agent. The data were substantiated with histopathological studies of rat liver sections. Conclusion:These results comprehensively depict that T. wallichiana extracts are endowed with the free radical sequestering potential and be employed as potential antioxidant and hepatoprotective arsenal against many oxidative stress linked diseases.

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Section: Reducing Power Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…It is consumed as decoctions, herbal tea, and juice for treating cold, cough, respiratory infections, indigestion, and epilepsy. It is used locally on the infected wounds and burns [6,8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In Vitro Antioxidant Potential and Hepatoprotective Activity of Taxus Wallichiana

Bhat

Ganie

Dar

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…Methanolic T. capensis leaves extract (100, 200 and 500 mg/kg body weight) and paracetamol (150 mg/kg body weight) served as the reference drug given orally 24 h after the yeast injection. The temperatures were recorded at [1][2][3][4] h after the drug treatment [12,13] .…”

Section: Yeast-induced Hyperpyrexia In Ratsmentioning

confidence: 99%