Anticonvulsant, anxiolytic and sedative activities of the aqueous root extract of Securidaca longepedunculata Fresen.

Adeyemi, Olufunmilayo O.; Akindele, Abidemi J.; Yemitan, Omoniyi K.; Aigbe, Flora Ruth; Fagbo, F.I.

doi:10.1016/j.jep.2010.04.028

Cited by 74 publications

(49 citation statements)

References 19 publications

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“…Moreover, acute toxicity studies of the aqueous whole root extract on mice revealed LD 50 values of 1.740 g/kg and 0.020 g/kg for the oral and intraperitoneal application routes respectively (Adeyemi et al, 2010), while Dapar et al (2007) reported an LD 50 of 0.037 g/kg when aqueous root extracts were administered orally to albino rats (Sprague Dawley strain). Elsewhere, the 80% ethanol extract of the root bark exhibited an LD 50 of 0.547 g/kg against albino mice (Keshebo et al, 2014).These findings may well suggest that the root bark extract has greater acute toxicity than the whole root extract following oral administration.…”

Section: Toxicologymentioning

confidence: 99%

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Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology

Mongalo

McGaw

Finnie

et al. 2015

Journal of Ethnopharmacology

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Ethnopharmacologicalrelevance: Securidaca longipedunculata Fresen (Polygalaceae) is a multi-purpose plant with a long history of use in African traditional medicine to treat various sexually transmitted infections, hernias, coughs, fever, ascariasis, constipation, headaches, rheumatism, stomach ache, malaria, tuberculosis, pain, epilepsy, pneumonia, skin infections, and it is also used as an aphrodisiac for men. The current paper provides an overview of the present phytochemistry, toxicology, ethnomedicinal uses and pharmacological properties of S. longipedunculata. Materials and methods:The information reported in this paper was collected from a literature search using various computerised databases including ScienceDirect, Moreover, the pharmacokinetic properties of extracts and compounds of the species need to be explored as there is insufficient data available on these aspects.

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Section: Toxicologymentioning

confidence: 99%

“…The aqueous extract of the root exhibited anticonvulsant, anxiolytic and sedative activities against mice in a dose dependent manner (Adeyemi et al, 2010;Okomolo et al, 2011), suggesting that the plant extract may be used in the management of convulsion and psychosis.…”

Section: Anticonvulsant Sedative and Anxiolytic Propertiesmentioning

confidence: 99%

Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology

Mongalo

McGaw

Finnie

et al. 2015

Journal of Ethnopharmacology

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show abstract

“…The findings in this study is supported by that of Auwal et al (2012) who reported that the aqueous root bark extract was slightly toxic to albino rats with an LD 50 of 0.771 g/kg, Agbaje and Adekoya (2012) reported an LD 50 of 3.16 g/kg when administered orally to rats. Moreover, acute toxicity studies of the aqueous whole root extract on mice revealed LD 50 values of 1.740 and 0.020 g/kg for the oral and intraperitoneal application routes respectively (Adeyemi et al, 2010). Elsewhere, the 80% ethanol extract of the root bark exhibited an LD 50 of 0.547 g/kg against albino mice (Keshebo et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effect of Securidaca longepedunculata root-bark methanol extract on testicular morphometry of New Zealand rabbits

Chika¹,

Luka²,

Azubuike³

2017

J. Vet. Med. Anim. Health

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The aim of this work was to determine the effect of the root-bark extract of Securidaca longepedunculata in the improvement of fertility in buck rabbits as envisioned by morphometric indices of the testes. Testicular morphometry of New Zealand rabbits was studied following treatment with different doses of the extract. The extract was administered per os in three doses of 0, 50 and 100 mg/kg body weight to three treatment groups of rabbits A, B, and C respectively for 29 days in a completely randomized designed (CRD). Eighteen mature buck rabbits between the ages of 18 and 24 months and with initial body weight (1.1 to 1.9 kg) were used. Each group comprised of three rabbits replicated twice. After the period of treatment, rabbits were weighed and sacrificed. Mean absolute paired testes weight, testes length and testes width were obtained and expressed relative to body weight at sacrifice. The results showed a significant difference in the mean relative paired testes weight, testes length and testes width between groups (p<0.05). The treated group given 50 mg/kg body weight of the extract had the highest mean absolute and relative paired testes weight of 3.325 ± 0.1349 a g and 0.2098 ± 0.0139 a % with mean absolute and relative testes length of 2.4522 ± 0.0250 a cm and 0.1538 ± 0.0040 a %. While the group given 100 mg/kg body weight of the extract had the lowest values of 2.634 ± 0.2762 b g and 0.1565 ± 0.0124 b % with mean absolute and relative paired testes length of 2.1600 ± 0.0807 b cm and 0.1299 ± 0.0039 b % respectively. It was concluded that administration of the extract at 50 mg/kg body weight yielded higher testicular parameters of buck rabbits. It was recommended that the use of the extract in bucks should be done with caution in relation to dose and length of treatment and that a detailed research should be carried out to evaluate the semen quality of bucks treated with 50 mg/kg the extract.

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“…Sodium pentobarbitone-induced hypnosis was used to assess the sedative activity of pPPB as previously described (Adeyemi et al, 2010). Different groups of mice (n=6) were randomly selected into negative, positive and test groups.…”

Section: Sedative Testmentioning

confidence: 99%

Isolation of Novel Para-Pentyl Phenyl Benzoate From Mondia WHITEI.(HOOK.F.) Skeels (Periplocaceae), Its Structure, Synthesis and Neuropharmacological Evaluation

Taiwo

Osasan

Olubiyi

et al. 2016

AJTCAM

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Background: Mondia whitei L. (Hook. F.) Skeels (Periplocaceae) is a medicinal plant used locally in managing pain, fever, loss of appetite and as aphrodiasc in the South-Western states of Nigeria. However, the fruit is consumed habitually in the South-Eastern states of Nigeria, leading to speculation that it may possess some central nervous system effect but which has not been scientifically investigated, hence this study. Methodology: Fresh fruits of Mondia whitei were collected and identified by a taxonomist. They were chopped into small pieces and extracted with absolute ethanol. The crude extract was subjected to various chromatographic techniques to isolate a novel compound whose structure was elucidated from the analysis of the crystal data and by extensive use of spectroscopy. The structure was confirmed by synthesis. The compound was subjected to anxiolytic and sedative activity assay. Computational analysis of the receptor binding event of isolated compound at the gamma amino butyric acid A receptor was also evaluated. Results: The structure of the compound was elucidated as para pentyl phenyl benzoate. The neuropharmacological evaluation of the compound indicated significant (p<0.05) depression of the central nervous system. The binding characteristics of the compound to gamma amino butyric acid A receptors appears to be more favorable than those obtained for gamma amino butyric acid, chlorpromazine, benzamidine, and is comparable with the affinity obtained for pentobarbitone and diazepam. Conclusion: These present data provide evidence for the role of para pentyl phenyl benzoate in the habitual consumption of the fruit as well as its central nervous system activities.

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Anticonvulsant, anxiolytic and sedative activities of the aqueous root extract of Securidaca longepedunculata Fresen.

Cited by 74 publications

References 19 publications

Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology

Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology

Effect of Securidaca longepedunculata root-bark methanol extract on testicular morphometry of New Zealand rabbits

Isolation of Novel Para-Pentyl Phenyl Benzoate From Mondia WHITEI.(HOOK.F.) Skeels (Periplocaceae), Its Structure, Synthesis and Neuropharmacological Evaluation

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