Anticonvulsant Drugs and Chromosomes

Márquez-Monter, H; Ruiz-Fragoso, Elvira; Velasco, Marcos

doi:10.1016/s0140-6736(70)90049-8

Cited by 12 publications

(4 citation statements)

References 8 publications

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“…A significant increase in CA rates in adults treated with A E D has been reported previously [1, 9,11,12,14] in contrast, no increase was observed in epileptic children [3,5,13].…”

Section: Introductionsupporting

confidence: 60%

Increased chromosomal breakage in epileptic children after long-term treatment

Curatolo¹,

Brinchi²,

Cusmai³

et al. 1986

Eur J Pediatr

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To investigate the mutagenic effects of antiepileptic drugs (AED), 39 epileptic children treated by long-term monotherapy (10 cases with Pb, 11 with Cbz, 9 with Vpa, 8 with Pht) have been studied. The long-term administration was monitored by measurement of AED serum concentrations by gaschromatography. Metaphase chromosome observations were performed using short time culture of peripheral blood lymphocytes and 100 mitoses from each proband were analyzed. A significant increase of CA in the group of patients with Pb (0.23), Cbz (0.19), Vpa (0.25), Pht (0.18) as compared with those of nine epileptic children without treatment (0.08) has been found. Because unrepaired damage of DNA may act as a possible carcinogenic potential, the shortest possible duration of AED treatment is recommended.

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“…A significant increase in CA rates in adults treated with A E D has been reported previously [1, 9,11,12,14] in contrast, no increase was observed in epileptic children [3,5,13].…”

Section: Introductionsupporting

confidence: 60%

Increased chromosomal breakage in epileptic children after long-term treatment

Curatolo¹,

Brinchi²,

Cusmai³

et al. 1986

Eur J Pediatr

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“…Roman and Caratzali [17] recognized high-level abnormal metaphase in bone marrow cells of rats treated with phenytoin, and this anomaly recovered to the normal level 7 days after withdrawal, mentioning the relevance between chromosome abnormality and folic acid synthesis inhibit ing the action induced by anticonvulsant drugs. As a common chromosome ab normality appearing in users of anticonvulsant drugs,Mdrquez-Monter et al [9] described numerous abnormalities such as tetraploidy or hypotetraploidy, but there were other reports which insisted on the increase of breaks [14] or exchange-type abnormalities [6]. In our study, abnormal cells were more frequent in 7 epileptic mothers who received anticonvulsant drugs for over 8 years than in the 2 who received the drugs for 7 years.…”

Section: Discussioncontrasting

confidence: 39%

Effects of Long-Term Administration of Anticonvulsant Drugs on Chromosomes in Man

Matsushima¹,

Hazama²,

Kawahara³

1981

Int Pharmacopsychiatry

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Effects of long-term administration of anticonvulsant drugs on chromosomes in epileptic mothers and their children were examined. Specimens from peripheral lymphocytes were prepared by incubation for 3 days and colchicine treatment. Results obtained were as follows: (1) The incidence of abnormal cells in the epileptic mother group over 9 years of drug administration was significantly higher than in the group below 9 years. (2) Most of chromosome abnormalities found in subjects were of comparatively simple morphological aberrations such as gaps or breaks. The incidence of the chromosome-type abnormalities was significantly higher in the patient group than in the control group. (3) Chromosome abnormality of children showed a positive correlation with that of mothers but was not significant. (4) The incidence of chromosome abnormality in children was reduced along with aging. (5) These observations could be interpreted to suggest that chromosome abnormality appearing in children born from epileptic mothers under drug therapy was probably formed by direct effects of anticonvulsant drugs on the fetal hematopoietic system.

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“…Although the mutagen hypothesis is supported by the observation that dph may induce chromosomal alterations under some conditions (29), it seems unlikely for several reasons.…”

mentioning

confidence: 99%