Anticonvulsant effects of sertraline: a case report

Brennecke, Anja; Weaver, Donald F.

doi:10.1016/j.seizure.2020.05.016

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Moreover, other studies with fluoxetine indicated decreased seizure duration and increased seizure threshold, survival, and seizure delay in various epilepsy models [31, 32]. In another study, sertraline exhibited anticonvulsant effects in clinical and experimental studies [33]. However, certain studies showed that SSRI antidepressants might increase the risk of seizure after traumatic brain injuries or strokes in Danish and Taiwanese populations [34, 35].…”

Section: Discussionmentioning

confidence: 98%

Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ‐induced kindling rat model

Taşkıran¹,

Ünal²

2021

Epileptic Disorders

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Objective. This study aimed to examine the effects of vortioxetine, a novel antidepressant, on epileptiform activity in pentylenetetrazole (PTZ)-induced kindling model in rats. Methods. For this purpose, 20 male Wistar Albino rats were used, and epileptiform activity was induced by injection of PTZ (35 mg/kg, i.p., three times a week). In the vortioxetine groups, vortioxetine (5 mg/kg and 10 mg/kg) was administered before the kindling process. During the kindling process, the Fisher and Kittner seizure scales were used to score seizure severity. After kindling, novel object recognition (NOR) tests were performed to evaluate the cognitive performance of rats. Electrodes were implanted into the fully kindled animals for ECoG recordings. Results. In the PTZ group, the number of total spikes was 1367AE136 spikes/ 20 minutes. First myoclonic jerks decreased while seizure severity and total spike count increased in the PTZ group. On the other hand, the total spike number and seizure severity significantly decreased and first myoclonic jerks increased in the vortioxetine groups compared to the PTZ group. Based on the NOR test, vortioxetine administration markedly raised the discrimination index compared to the PTZ group. Significance. Electrophysiological and behavioural data from the present study suggest that vortioxetine, a novel drug, plays a critical role in controlling PTZ-induced epileptiform activity in rats. Vortioxetine may therefore be a valuable candidate to prevent seizure activity and treat cognitive deficits associated with epilepsy.

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Section: Discussionmentioning

confidence: 98%

Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ‐induced kindling rat model

Taşkıran¹,

Ünal²

2021

Epileptic Disorders

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“…Only a few antidepressants have relatively high dose-related proconvulsant effects; they include amoxapine, bupropion, amitriptyline and clomipramine (Tallian 2017). For the remainder, the risk is low and sertraline may even have anticonvulsant effects (Brennecke 2020).…”

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confidence: 99%

Are antidepressants really safe and effective in people with epilepsy and depression?

Makan

2022

BJPsych advances

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SUMMARY This commentary gives a very brief overview of depression in epilepsy (prevalence, risk, associations between the two conditions, antidepressant medication) and assesses the quality and results of a Cochrane Review comparing antidepressants with placebo and psychotherapy in managing the condition. Although antidepressants were not shown to be more effective than other interventions and no link between antidepressants and increased seizure frequency was observed, the low-quality evidence obtained cannot provide conclusive answers.

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Anticonvulsant effects of sertraline: a case report

Cited by 2 publications

References 4 publications

Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ‐induced kindling rat model

Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ‐induced kindling rat model

Are antidepressants really safe and effective in people with epilepsy and depression?

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