Anticonvulsant‐Induced Status Epilepticus in Lennox‐Gastaut Syndrome

Bittencourt, P. R. M.; Richens, A.

doi:10.1111/j.1528-1157.1981.tb04339.x

Cited by 54 publications

(24 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…De novo appearance of myoclonic jerks was described in several reports on children or young adults with cryptogenic or symptomatic partial epilepsy treated with addon VGB (37,46,47). Only in a minority of these patients was the "epileptic" origin of myoclonus demonstrated.…”

Section: Vigabatrinmentioning

confidence: 99%

“…If this hypothesis is well founded, response to treatment is likely to be determined more by the morphology of the EEG waveform than by the partial or generalized nature of the idiopathic epilepsy. A preliminary comparative analysis of the rolandic discharge morphology between patients with BRE accompanied only by typical facial (32)(33)(34)(35)(36)(37)(38). In most of these patients, BDZs had been administered for treatment of absence status.…”

Section: Carbamazepinementioning

confidence: 99%

See 1 more Smart Citation

Antiepileptic Drug‐Induced Worsening of Seizures in Children

Guerrini

Belmonte

Genton³

1998

Epilepsia

164

126

View full text Add to dashboard Cite

Summary: Antiepileptic drugs (AEDs) may aggravate preexisting seizures and trigger new seizure types. However, the extent and mechanisms of this problem are unclear, for several reasons. AED trials are not designed to detect worsening of seizures, severe childhood epilepsies may fluctuate in severity, and worsening of seizures may be over-hastily ascribed to the introduction of a new AED. Moreover, the seizure and the epilepsy type may have been incorrectly diagnosed. The problem is identification of true aggravation of epilepsy in the absence of overdosage or toxicity. This is a common and clinically important problem that concerns both established and newer AEDs, but the biologic mechanisms involved are unknown. An increase in seizure frequency due to overdosage has been reported with phenytoin but is rare with other AEDs. Paradoxical reaction has been reported with carbamazepine (CBZ), benzodiazepines, and vigabatrin (VGB). Exacerbation of seizures may also occur during AED-induced encephalopathy or hepatopathy. An inappropriate choice of the AED (i.e., a purely pharmacodynamic mechanism) can induce worsening when CBZ or VGB is used in absence and myoclonic seizures. Further research should determine whether seizure exacerbation is associated with the type of epilepsy or with the type of EEG abnormality. Recent evidence indicates that lamotrigine i8 inappropriate in severe myoclonic epilepsy. Some childhood epileptic encephalopathies have been affected by certain seizure-worsening mechanisms. Whether this is due to a predisposition in specific syndromes or to an increased risk for adverse effects in patients undergoing multiple AED manipulations is unclear. Furthermore, some syndromes are not the sum of accompanying seizure types but have unique neurobiology.

show abstract

Section: Vigabatrinmentioning

confidence: 99%

Section: Carbamazepinementioning

confidence: 99%

Antiepileptic Drug‐Induced Worsening of Seizures in Children

Guerrini

Belmonte

Genton³

1998

Epilepsia

164

126

View full text Add to dashboard Cite

show abstract

“…[18][19][20][21][22] Benzodiazepinler GABA-A reseptörleri üzerinden etki ederler, GABA-B reseptörleri üzerinden etkileri yoktur o yüzden benzodiazepinlere bağlı LGS'de tonik status epileptikusun ortaya çıkması, yukarıda tartışılan talamik mekanizmalarla tam olarak açıklanamamaktadır. [4] Altta yatan ciddi beyin patolojisi [4] veya benzodiazepinlere bağlı somnolansın [23] artmış nöbet aktivitesine yol açtığı düşünülmektedir.…”

Section: Discussionunclassified

A Case of Lennox-Gastaut Syndrome Who Developed Tonic Status Epilepticus Induced by Intravenous Diazepam

Atmaca¹,

Baykan²,

Bebek³

et al. 2012

Epilepsi

View full text Add to dashboard Cite

ÖzetLennox-Gastaut sendromu (LGS) çok sayıda nöbet tipinin birlikte görüldüğü, özel EEG paternlerine sahip, kognitif etkilenmenin de olduğu, tedaviye dirençli ve kötü prognozlu bir epileptik ensefalopatidir. Bazı antiepileptik ilaçların (AEİ), özellikle çocukluk çağının jeneralize epilepsilerinde, bazı nöbet tiplerini kötüleştirici etkisi iyi bilinen bir fenomendir; ancak bunun altında yatan patogenetik mekanizmalar tam olarak anlaşılmış değildir. Bu yazıda, LGS tanısı ile izlenen, intravenöz diazepam ile tonik status epileptikusa giren bir olgu bildirilmiş, LGS ve AEİ'lere bağlı nöbet kötüleşmesi konusu tartışılmıştır.Anahtar sözcükler: Diazepam; Lennox-Gastaut sendromu; nöbet kötüleşmesi. SummaryLennox-Gastaut syndrome (LGS) is an epileptic encephalopathy characterized by several types of seizures, special EEG patterns, and cognitive deterioration with resistance to therapy and poor prognosis. It is a well known phenomenon that some antiepileptic drugs (AED) have a worsening effect on some seizure types, especially in the generalized epilepsies of childhood. However, its underlying pathogenetic mechanisms are not fully understood. In this paper, a case with LGS who developed tonic status epilepticus induced by diazepame given intravenously is reported and the topic of seizure aggravation caused by AED and LGS is discussed.

show abstract

“…More interestingly, increased seizure activity can also occur when antiepileptic drugs are used appropriately. Tassinari and colleagues (1972) and, more recently, Bittencourt and Richens (1981) reported a paradoxical effect of intravenous benzodiazepines, producing status epilepticus in children with the Lennox-Gastaut syndrome. According to the latter authors, the decreased level of consciousness induced by benzodiazepines and other CNS depressants could be the cause of this paradoxical effect.…”

Section: Antiepileptic Drugs and Their Paradoxical Proconvulsant Actimentioning

confidence: 96%

Clinical Features, Pathogenesis and Management of Drug-Induced Seizures

1990

View full text Add to dashboard Cite

Many classes of pharmacological agents have been implicated in cases of drug-induced seizures. The list includes antidepressant drugs, lithium salts, neuroleptics, antihistamines (H1-receptor antagonists), anticonvulsants, central nervous system stimulants, general and local anaesthetics, antiarrhythmic drugs, narcotic and non-narcotic analgesics, non-steroidal anti-inflammatory drugs, antimicrobial agents, antifungal agents, antimalarial drugs, antineoplastic drugs, immunosuppressive drugs, radiological contrast agents and vaccines. For each of these classes of drugs, this article offers a revision of the literature and emphasises in particular the frequency of the adverse reaction, its clinical presentation, its presumed epileptogenic mechanism and the therapeutic strategy for the management of drug-induced seizures. An attempt is also made to distinguish seizures induced by standard dosages from those provoked by accidental or self-induced intoxication. For some classes of drugs such as antidepressants, neuroleptics, central nervous system stimulants (e.g. theophylline, cocaine, amphetamines) and beta-lactam antibiotics, seizures are a well recognised adverse reaction, and a large body of literature has been published discussing exhaustively the major aspects of the issue; sufficient data are available also for the other classes of pharmacological agents mentioned above. In contrast, several other drugs [e.g. allopurinol, digoxin, cimetidine, protirelin (thyrotrophin releasing hormone), bromocriptine, domperidone, insulin, fenformin, penicillamine, probenecid, verapamil, methyldopa] have not been studied thoroughly under this aspect, and the only source of information is the occasional case report. This review does not address the issue of seizures induced by drug withdrawal.

show abstract

Anticonvulsant‐Induced Status Epilepticus in Lennox‐Gastaut Syndrome

Cited by 54 publications

References 13 publications

Antiepileptic Drug‐Induced Worsening of Seizures in Children

Antiepileptic Drug‐Induced Worsening of Seizures in Children

A Case of Lennox-Gastaut Syndrome Who Developed Tonic Status Epilepticus Induced by Intravenous Diazepam

Clinical Features, Pathogenesis and Management of Drug-Induced Seizures

Contact Info

Product

Resources

About