Anticonvulsant long-term and rescue medication: The children's perspective

Woltermann, Sarah; Jeschke, Sarah; Herziger, Birthe; Müller, Ruth Melinda; Kieß, Wieland; Bertsche, Thilo; Bertsche, Astrid; Neininger, Martina Patrizia

doi:10.1016/j.ejpn.2020.06.009

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…Preferences of children and parents concerning drug formulations differed in around half of the reports. Our findings are in line with earlier studies that have shown that children are indeed well able to express experiences and expectations concerning their drug therapy [23,24]. Nevertheless, physicians tend to talk to the parents when they aim at exploring the children's needs.…”

Section: Expectations Of the Ideal Pediatric Drug (Part B)supporting

confidence: 91%

Drug-handling problems and expectations of the ideal pediatric drug—reported by children and their parents

et al. 2022

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Experienced drug-handling problems and inadequately considered expectations for drug therapy have an unfavorable influence on therapy. We performed a questionnaire survey in (i) parents of 0–5-year-old children and (ii) 6–17-year olds and their parents. We assessed (A) experienced drug-handling problems and (B) expectations for drug therapy. (i) Forty-six parents and (ii) 103 children and their parents participated in the study. Experienced drug-handling problems were described by (i) 100% of parents and (ii) 62% of children and 70% of parents. Problems concerned with the preparation of the drug, dosing, compliance with the time interval, and acceptance. (i) Sixty-five percent of parents preferred a peroral route of drug administration, while (ii) 74% of children and 86% of parents did so. Preferred characteristics of peroral drug formulations, e.g., liquid versus solid drug formulations or flavor, were highly heterogeneous. Preferences of 6–17-year-old children and their parents matched in 43 to 66%. Conclusion: Most children and their parents had already experienced drug-handling problems. Preferences concerning the ideal pediatric drug were highly heterogeneous and in about half of cases, preferences of children and their parents differed. Thus, the children should be approached directly. If information is solely gained from parents, the children’s needs might remain unmet. What is Known:• Pediatric drug administration is complex and therefore error-prone.•Experiences and expectations of children and their parents should be considered. What is New:•Most pediatric patients and their parents have already experienced drug-handling problems.• Expectations concerning the ideal pediatric drug are highly heterogeneous. Parents are often insufficiently aware of those expectations in their children.

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Section: Expectations Of the Ideal Pediatric Drug (Part B)supporting

confidence: 91%

Drug-handling problems and expectations of the ideal pediatric drug—reported by children and their parents

et al. 2022

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“…Preferences of children and parents concerning drug formulations differed in around half of the reports. Our ndings are in line with earlier studies that have shown that children are indeed well able to express experiences and expectations concerning their drug therapy [10,22]. Nevertheless, physicians tend to talk to the parents when they aim at exploring the children's needs.…”

Section: Expectations Of the Ideal Pediatric Drug (Part B)supporting

confidence: 90%

Drug-Handling Problems and Expectations of the Ideal Pediatric Drug — Reported by Children and Their Parents

Herziger

Jeschke

Müller

et al. 2021

Preprint

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Experienced drug-handling problems and inadequately considered expectations for drug therapy have an unfavorable influence on therapy. We performed a questionnaire survey in (i) parents of 0–5-year-old children and (ii) 6–17-year-olds and their parents. We assessed (A) experienced drug-handling problems and (B) expectations for drug therapy. (i) 46 parents and (ii) 103 children and their parents participated in the study. Experienced drug-handling problems were described by (i) 100% of parents and (ii) 62% of children and 70% of parents. Problems concerned the preparation of the drug, dosing, compliance with the time interval, and acceptance. (i) 65% of parents preferred a peroral route of drug administration, while (ii) 74% of children and 86% of parents did so. Preferred characteristics of peroral drug formulations, e.g. liquid versus solid drug formulations or flavor, were highly heterogeneous. Preferences of 6–17-year-old children and their parents matched in 43% to 66%. Conclusion: Most children and their parents had already experienced drug-handling problems. Preferences concerning the ideal pediatric drug were highly heterogeneous and in about half of cases, preferences of children and their parents differed. Thus, the children should be approached directly. If information is solely gained from parents, the children’s needs might remain unmet.

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“…Parents have different desires on how potential ADRs are communicated to them [ 10 ]. Thus, it is important that physicians take the parents’ and patients’ concerns seriously and provide advice to alleviate those concerns, offer support and give further explanations, e.g., on the importance of regular drug intake [ 9 , 10 , 26 ]. In addition, children and adolescents with chronic conditions desire to be actively involved in physicians’ counseling [ 9 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is important that physicians take the parents' and patients' concerns seriously and provide advice to alleviate those concerns, offer support and give further explanations, e.g., on the importance of regular drug intake [9,10,26]. In addition, children and adolescents with chronic conditions desire to be actively involved in physicians' counseling [9,26,27]. Those measures also could contribute to increase patients' adherence [28][29][30].…”

Section: Communication On Adrsmentioning

confidence: 99%

Physicians’ perspectives on adverse drug reactions in pediatric routine care: a survey

Neininger

Jeschke²,

Kiesel

et al. 2021

World J Pediatr

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Background Children and adolescents are at particular risk for adverse drug reactions (ADRs). We investigated physicians’ perceptions on ADRs in pediatric routine care. Methods In this exploratory study from April to November 2020, we invited physicians treating pediatric patients across Germany to complete an online questionnaire consisting mainly of closed questions. Results Completion rate was 98% (127/129). Of all participants, 23% (29/127) stated they were not able to estimate how many of their pediatric patients experienced ADRs during drug therapy. The remaining physicians estimated that 7.5% (median; Q25/Q75 3%/20%) of their pediatric patients were affected by ADRs. Regarding counseling on ADRs, 61% (77/127) stated they do not ask regularly the extent to which parents want to be informed. In total, 26% (33/127) stated they avoid counseling on ADRs concerning commonly used approved therapies, whereas only 4% (5/127) did so concerning off-label use (P < 0.001). Altogether, 16% (20/127) stated they rather prescribe new medicines as they hope for better effectiveness; 72% (91/127) said they are cautious about doing so owing to yet unknown ADRs. Of all respondents, 46% (58/127) stated they do not report ADRs to the authorities. Concerning the black triangle symbol, a European pharmacovigilance measure, 11% (14/127) stated they knew it and 6% (7/127) stated they reported any suspected ADR for drugs with that symbol. Conclusions Physicians’ perspectives on ADRs were ambivalent: ADRs influenced their parent counseling and drug prescribing; yet, they struggled to estimate the impact of ADRs on their patients and were not aware of specific pharmacovigilance measures.

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Anticonvulsant long-term and rescue medication: The children's perspective

Cited by 5 publications

References 27 publications

Drug-handling problems and expectations of the ideal pediatric drug—reported by children and their parents

Drug-handling problems and expectations of the ideal pediatric drug—reported by children and their parents

Drug-Handling Problems and Expectations of the Ideal Pediatric Drug — Reported by Children and Their Parents

Physicians’ perspectives on adverse drug reactions in pediatric routine care: a survey

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