Anticonvulsant Potency of 10 Various P-Isopropoxyphenylsuccinimide Derivatives in the Maximal Electroshock-Induced Seizure Threshold Model in Mice

Kocharov, S. L.; Panosyan, Henry A.; Marzęda, Paweł; Wróblewska-Łuczka, Paula; Kochman, Ewelina; Właź, Aleksandra; Łuszczki, Jarogniew J.

doi:10.5114/hpc.2017.70010

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…Moreover, the choice of these AEDs (lCM, CBZ and VPA) was considered to be ideal because the drugs in combination, due to their diverse molecular mechanisms of action, should theoretically provide maximal therapeutic effects and no or minimal side effects [18]. Thus, to confirm our hypothesis that the combination of lCM with CBZ and VPA was an "ideal" selection, we conducted experiments on male albino Swiss mice as described previously [6,8,9,19].…”

Section: Introductionmentioning

confidence: 98%

Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model

Kondrat-Wróbel¹,

Załuska²,

Walczak³

et al. 2019

hpc

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Authors' contribution Wkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane-analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary Background. It is estimated that approximately 1% of people worldwide suffer from epilepsy. Currently available antiepileptic drugs (AEDs) are able to control epileptic seizures in about 70% of cases. In the remaining patients (30%), the application of two or three AEDs in combination is necessary for effective seizure management. The goal of this work was to characterize the interaction of three AEDs: lacosamide (lCM), carbamazepine (CBZ) and valproate (VPA) at the fixed-ratio of 1:1:1 in the mouse tonic-clonic seizure model. Material and methods. Male albino Swiss mice, after receiving a combination of lCM, CBZ and VPA, were challenged with electric current to evoke tonic hind limb extension (seizure activity). Protection of the mice from tonic-clonic seizures was assessed by isobolographic analysis to determine the type of interaction occurring between these drugs. Results. Type I isobolographic analysis revealed that the combination of lCM, CBZ and VPA produced infra-additive (antagonistic) interaction in the mouse tonic-clonic seizure model. Conclusions. Since the three-drug mixture of lCM, CBZ and VPA exerted an antagonistic interaction in the tonic-clonic seizure test in mice, we would caution physicians against treating epilepsy patients with this unfavorable combination.

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Section: Introductionmentioning

confidence: 98%

Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model

Kondrat-Wróbel¹,

Załuska²,

Walczak³

et al. 2019

hpc

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“…To examine the effect of citicoline in modulation of susceptibility to ECT-induced seizure [26,27,28], an electroconvulsive therapy apparatus (Model 7800, Ugo Basile, Camerio, Italy) was applied. Tonic convulsions of the hind extremities of mice were induced by passing alternating current (50 Hz, 50 mA and 0.2 s) via ear electrodes.…”

Section: Electroshock Testmentioning

confidence: 99%

Posible involvement of nitric oxide in anticonvulsant effects of citicoline on pentylenetetrazole and electroshock induced seizures in mice

Rasooli

Pirsalami

Moezi

2020

Heliyon

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Cerebroneurovascular trauma is recognized as an important risk factor in the development of seizure and epilepsy. Administration of citicoline in these situations is a conventional therapeutic strategy, which combines neurovascular protection and repair effects. The aim of the present study is clarifying the effect of acute and subchronic citicoline administration on pentylenetetrazole (PTZ) and electroshock induced seizures in mice. Besides we examined the probable role of NO and its interaction with citicoline in seizure experiments.Male mice were received acute and sub-chronic regimens of different doses of citicoline (62.5, 125, 250 and 500 mg/kg) before the intravenous or intraperitoneal PTZ-induced seizures or electroshock. To clarify the probable role of NO, 7-nitroindazole (7-NI) (60 mg/kg) or aminoguanidine (AG) (100 mg/kg) were injected 5 min before citicoline in separate groups.The results revealed that neither acute nor sub-chronic treatment with citicoline could affect the seizures induced by intravenous or intraperitoneal PTZ, but in electroshock model, citicoline showed anti-epileptic properties. Co-administration of citicoline and selective nitric oxide synthase (NOS) inhibitors amplified the anticonvulsant effect of citicoline.The current results indicated that citicoline has anticonvulsant effects probably through the inhibition of NO.

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“…With this purpose in mind, a series of its N-aryl and Narylaminomethyl analogs, as well as joining the starting imide through the benzene ring using 1,2phenylenediamine, were synthesized. Relatively recently, some p-isopropoxyphenylsuccinimide derivatives were tested in the maximal electroshockinduced seizure threshold (MEST) test and their anticonvulsant properties described (16).…”

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confidence: 99%

Synthesis and Anticonvulsant Properties of Some N-Aryl and N-Arylaminomethyl Derivatives of 3-P-Isopropoxyphenylpyrrolidine-2,5-Dione

Kocharov¹,

Panosyan²,

Chmielewski³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Anticonvulsant properties of newly synthesized compounds and potential antiepileptic drugs are usually assessed in screen tests in experimental animals. One of the most commonly used screen tests in mice is the maximal electroshock-induced seizure test that reflects tonic-clonic seizures in humans. A series of 3-p-isopropoxyphenylpyrrolidine-2,5-dione derivatives, including N-aryl and N-arylaminomethyl analogs, were characterized for their anticonvulsant properties in the maximal electroshock-induced seizure test in mice. Electroconvulsions (tonic-clonic seizures) were evoked in adult Albino Swiss mice by a current (sine-wave, 25 mA, 50 Hz, 500 V, 0.2 s stimulus duration) delivered via auricular electrodes. N-aryl derivatives did not show any anticonvulsant activity, whereas some representatives of N-arylaminomethyl derivatives, i.e. N-Mannich bases, exhibited a distinct protective action against maximal electroshock-induced (MES) convulsions in mice. Several N-arylaminomethyl derivatives of 3-p-isopropoxyphenylpyrrolidine-2,5-dione may become in future new antiepileptic drugs, or they could serve as valuable supporting materials for obtaining new derivatives with stronger anticonvulsant activities than their maternal compounds.

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Anticonvulsant Potency of 10 Various P-Isopropoxyphenylsuccinimide Derivatives in the Maximal Electroshock-Induced Seizure Threshold Model in Mice

Cited by 9 publications

References 17 publications

Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model

Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model

Posible involvement of nitric oxide in anticonvulsant effects of citicoline on pentylenetetrazole and electroshock induced seizures in mice

Synthesis and Anticonvulsant Properties of Some N-Aryl and N-Arylaminomethyl Derivatives of 3-P-Isopropoxyphenylpyrrolidine-2,5-Dione

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