Anticonvulsant Profile of Ondansetron in Rats

Sadasivam, Balakrishnan; Bhargava, V.K.; Pandhi, P

doi:10.1006/ebeh.2000.0028

Cited by 16 publications

(15 citation statements)

References 12 publications

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“…52 Balakrishnan and colleagues even reported an anticonvulsant profile for ondansetron in maximal electroshock-induced seizures in rats. 53 Contrarily, this 5-HT 3 antagonist was also shown to increase hippocampal theta rhythm 5 and to decrease the firing rate of hippocampal inhibitory interneurons, 54 leading to an increase firing rate of pyramidal cells.…”

Section: Discussionmentioning

confidence: 93%

Seizure susceptibility alteration through 5-HT3 receptor: Modulation by nitric oxide

Gholipour

Ghasemi

Riazi

et al. 2010

Seizure

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There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e.g. by SSRIs) has been reported to be anticonvulsant. This study was performed to determine the effect of selective 5-HT(3) channel/receptor antagonist granisetron and agonist SR57227 hydrochloride on the pentylenetetrazole (PTZ)-induced seizure threshold in mice. The possible interaction of this effect with nitrergic system was also examined using the nitric oxide (NO) synthase inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME) and the NO precursor l-arginine. SR57227 (10mg/kg, i.p.) significantly increased the seizure threshold compared to control group, while high dose granisetron (10mg/kg, i.p.) proved proconvulsant. Co-administration of sub-effective doses of the 5-HT(3) agonist with l-NAME (5 and 60mg/kg, i.p., respectively) exerted a significant anticonvulsive effect, while sub-effective doses of granisetron (3mg/kg) was observed to have a proconvulsive action with the addition of l-arginine (75mg/kg, i.p.). Our data demonstrate that enhancement of 5-HT(3) receptor function results in as anticonvulsant effect in the PTZ-induced seizure model, and that selective antagonism at the 5-HT(3) receptor yields proconvulsive effects. Furthermore, the NO system may play a role in 5-HT(3) receptor function.

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Section: Discussionmentioning

confidence: 93%

Seizure susceptibility alteration through 5-HT3 receptor: Modulation by nitric oxide

Gholipour

Ghasemi

Riazi

et al. 2010

Seizure

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“…A drop of electrolyte solution (0.9% NaCl) with lignocaine was applied to the corneal electrodes prior to application to the rats. This increases the contact and reduces the incidence of fatalities 11 . The observed duration of various phases of epilepsy was tabulated.…”

Section: Estimation Of Duration Of Epileptic Seizuresmentioning

confidence: 99%

“…Over activation of glutamate receptors may lead to delayed neuro degeneration as a result of increased influx of calcium ions into neurons. The well-established drugs like phenytoin, carbamazepine and benzodiazepines exerts their action by inhibiting calcium calmodulin stimulated protein phosphorylation in presynaptic nerve terminal 11 . A low concentration of dopamine in cerebellum also has an inhibitory effect on glutamate 18 .…”

Section: Effect On Biogenic Amine Estimationmentioning

confidence: 99%

Anti Epileptic Activity of Morinda citrifolia Linn Fruit Extract

Muralidharan¹,

Srikanth

2009

Journal of Chemistry

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Fruit extract ofMorinda citrifolia(Noni), a medicinal plant used in many neuro protective ayurvedic preparations was evaluated for its protective effect against seizures induced by Maximal Electro Shock (MES) method in rats. A daily dose of 200 and 400 mg/kg of the extract was administered to the animals for 15 days, after which seizures were induced by maximum electro shock method and the duration of various phases of epileptic attacks were recorded and compared with the control animals. A significant (P<0.01 and P<0.001) reduction in the time taken for righting reflex (recovery) was noted in the experimental animals. The levels of biogenic amines such as dopamine, serotonin and nor-adrenaline in the forebrain region were also estimated and a significant level of restoration was opserved in the extract treated animals. Significant results were opserved in the estimated parameters thereby justifying the use of this medicinal plant in the treatment of epilepsy.

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“…5‐HT 3 receptor antagonists have been shown to decrease the severity and increase the latency of audiogenic seizures in DBA/2J mice, and decrease the primary afterdischarge duration and the latency of the secondary afterdischarge in hippocampal seizures generated by electrical stimulation (Semenova & Ticku, 1992; Watanabe et al., 2000). Ondansetron at lower doses has also been reported to be effective against maximal electroshock‐induced seizures in rats, with potentiation of the effect of phenytoin (Balakrishnan et al., 2000).…”

Section: Discussionmentioning

confidence: 99%

Ondansetron and seizures

et al. 2009

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SUMMARYExperimental studies suggest that 5-hydroxytryptamine (5-HT) receptors play a role in epileptogenesis and seizure propagation. Ondansetron, a 5-HT 3 receptor antagonist, has been reported to have proconvulsant and anticonvulsant effects in animals. We describe three patients who developed seizures after receiving ondansetron. There were two females and one male. Ages ranged from 38-56 years. None had a previous or family history of seizures. Four milligrams (mg) of ondansetron was given intravenously for severe nausea and vomiting in association with migraine, gastritis, and diabetic ketoacidosis. A generalized tonicclonic seizure occurred in each patient-12, 15, and 22 min after injection. Brain magnetic resonance imaging (MRI) and electroencephalography (EEG) were normal in all patients. Although no antiepileptic drugs were given, none had seizure recurrence subsequently. The temporal relationship between ondansetron administration and seizures, lack of EEG or MRI abnormalities, and absence of seizure recurrence suggest that the seizures were causally related to ondansetron in our patients.

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Anticonvulsant Profile of Ondansetron in Rats

Cited by 16 publications

References 12 publications

Seizure susceptibility alteration through 5-HT3 receptor: Modulation by nitric oxide

Seizure susceptibility alteration through 5-HT3 receptor: Modulation by nitric oxide

Anti Epileptic Activity of Morinda citrifolia Linn Fruit Extract

Ondansetron and seizures

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