Anticonvulsant properties of methanol leaf extract of Laggera Aurita Linn. F. (Asteraceae) in laboratory animals

Malami, Sani; Kyari, Hadiza; Danjuma, Nuhu M; Ya’u, Jamilu; Hussaini, Isa M.

doi:10.1016/j.jep.2016.06.035

“…Anticonvulsant activity (10), anti-inflammatory and analgesic activity (11), antiviral, antibacterial and hepatoprotective proper-ties (12), and antinociceptive properties (13), have been reported by previous studies. The traditional use of the plant in epilepsy (10) and paediatric malaria have also been reported (14). This study aimed at establishing the anxiolytic property of methanol leaf extract of Laggera aurita (LAME).…”

Section: Introductionmentioning

confidence: 69%

“…Essential oils from the plant of L. aurita are used for the treatment of different diseases, such as cancer, atherosclerosis, and thrombosis (9). Anticonvulsant activity (10), anti-inflammatory and analgesic activity (11), antiviral, antibacterial and hepatoprotective proper-ties (12), and antinociceptive properties (13), have been reported by previous studies. The traditional use of the plant in epilepsy (10) and paediatric malaria have also been reported (14).…”

Section: Introductionmentioning

confidence: 81%

Anxiolytic-Like Effect of Methanol Leaf Extract of Laggera aurita Linn. F. (Asteraceae) in Mice

Guragi

¹

,

Kyari

²

,

Malami

³

2018

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Background: Laggera aurita belongs to the Asteraceae family; it is an annual herb found growing as weeds in Sub-Saharan Africa, including Nigeria. In Nigeria, Laggera aurita is used as a remedy for paediatric malaria and in the management of epilepsy. Previous studies on extracts of this plant suggested its anticonvulsant activity via GABA-mediated neurotransmission. Therefore, this study aimed at evaluating anxiolytic-like effect of the plant extract. Methods: Anxiolytic potential of the methanol leaf extract of Laggera aurita was evaluated using staircase, elevated plus maze, hole board, open field, beam walking assay, and diazepam-induced sleep tests. Results: The extract significantly (P < 0.05) decreased the number of rearing in the staircase test at 600 and 300 mg/kg. In the elevated plus maze test, there was a significant (P < 0.05 at 600 and 300 mg/kg) increase in the total number of open arm entries and total time spent in the open arms (600 mg/kg). In the hole board test, the extract significantly (P ≤ 0.05 at 600mg/kg) decreased the number of head dips. Using the open field test, the axiolytic activity of the extract was further reflected by the significant (P < 0.05) decrease in the number of rearing (150, 300, and 600 mg/kg). The effect of the extract on beam walking assay showed a significant (P < 0.05) increase (600 mg/kg) in number of foot slips and time spent on beam. The extract (600 mg/kg) significantly (P < 0.05) increased the duration of sleep induced by diazepam. Conclusions:The results of this study revealed that the leaf extract of Laggera aurita possesses anxiolytic-like properties.

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“…22,23 Picrotoxin-induced convulsion test The same procedure described above in the strychnine model was followed, except that convulsion was induced with picrotoxin 5 mg/kg i.p. 24…”

Section: Strychnine-induced Convulsion Testmentioning

confidence: 99%

Anticonvulsant, Muscle Relaxant and In-Vitro Antioxidant Activities of Hydroethanol Leaf Extract of Costus afer Ker Gawl (Costaceae) in Mice

Murtala¹,

Akindele²,

Oreagba³

2020

TJNPR

2

0

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oxidative stress is a possible mechanism for the onset and development of epilepsy, while Menon et al. 9 demonstrated seizureinduced oxidative stress by reporting significant increase in the level of oxidative makers in epileptic patients. Antioxidant therapy in animal models, supported by clinical data, has been demonstrated to reduce oxidative stress and frequency of seizures. 10,11 Muscle spasm is a short painful muscular contraction which may be due to epilepsy. A number of conventional anti-epileptics, muscle relaxants and antioxidant drugs are currently available, but epilepsy is still poorly managed in about 20% of affected individuals. 12 Diseases caused by oxidative damage are still on the increase and the episodes of skeletal muscle spasm continue unabated. Hence, focus remains strong on indigenous plants which are promising sources of new drugs with better efficacy and safety profile relative to conventional agents, apart from the desirable prospect of developing standardized herbal remedies for CNS disorders. Costus afer Ker Grawl (Costaceae), Bush/Monkey sugar cane, is a perennial, herbaceous and rhizomatous plant found in Asia, Africa and Americas. 13-15 In west and tropical Africa, it grows well in moist or shady forest. 16,17 In Nigeria and other West African countries, C. afer is often planted in home gardens for medicinal purposes, with documentation of use in traditional medicine to treat diabetes, inflammation, joint pains, 16 measles, fever, malaria, etc. The rhizome decoction of another species (Costus dubius) is used to treat epilepsy. 18 This study was carried out to investigate the anticonvulsant, muscle relaxant and in-vitro antioxidant activities of the hydroethanol leaf extract of Costus afer in mice.

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“…Its other uses include cough, fever, colic, headache, intestinal parasitic diseases, and malaria treatment. Its roots, stems, and leaves are used for the treatments in the form of enemas, poultices, infusions, lotion, or inhalations [ 13 , 14 ]. The plant grows widely in Ethiopia, specifically in Bale, Oromia Region [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of 70% Ethanol Extract and its Solvent Fractions of Artemisia afra (Jacq. Ex Willd.) against Pentylenetetrazole-Induced Seizure in Mice

Kediso

¹

,

Tolessa

²

,

Getachew³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Introduction. Artemisia afra (Jacq. ex Willd.), commonly called African wormwood, is a highly aromatic perennial herb and a well-known medicinal plant, claimed to be effective and safe in the treatment of epilepsy. The whole-plant extract is traditionally used as an antiepileptic agent in Ethiopia. Aim of the Study. The aim of this study was, therefore, to evaluate the anticonvulsant effect of the hydroethanolic extract and solvent fractions of A. afra whole part in mice. Materials and Methods. The effects of A. afra hydroethanolic extract and its solvent fractions were evaluated against pentylenetetrazole- (PTZ-) induced convulsions in mice. The onset and duration of PTZ-induced convulsions were determined with hydroethanolic A. afra extract and its solvent fractions. Data were analyzed using a one-way analysis of variance (ANOVA) followed by post hoc Tukey’s multiple comparisons test. p < 0.05 was considered statistically significant. Results. The hydroethanolic extract of A. afra, with all the three doses of 250, 500, and 1000 mg/kg, showed a significant delay (504.833 ± 62.835 ∗ s; p < 0.05 ∗ ; 551.833 ± 47.69 ∗ ∗ s; p < 0.01 ∗ ∗ ; and 808.333 ± 64.8 ∗ ∗ ∗ s; p < 0.001 ∗ ∗ ∗ , respectively) in the mean onset of convulsion and a decrease (17.000 ± 1.88 ∗ ∗ ∗ s, p < 0.05 ∗ ; 13.000 ± 1.8 ∗ ∗ s, p < 0.01 ∗ ∗ ; and 7.833 ± 1.07 ∗ ∗ ∗ s, p < 0.001 , respectively) in the mean duration of convulsion against PTZ-induced convulsion in a dose-dependent manner compared to the control (92.833 ± 13.006 s; 34.167 ± 3.683 s), and its anticonvulsant activity was significantly less compared to that of diazepam (1001.167 ± 68.430 s; 4.500 ± 0.619 s). The solvent fractions, however, did not show anticonvulsant activity against PTZ-induced convulsion. Conclusion. Crude extract of A. afra has an anticonvulsant effect in mice. This might be attributed to the synergistic effects of two or more active ingredients present in the herb.

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Anticonvulsant properties of methanol leaf extract of Laggera Aurita Linn. F. (Asteraceae) in laboratory animals

Cited by 14 publications

References 22 publications

Anxiolytic-Like Effect of Methanol Leaf Extract of Laggera aurita Linn. F. (Asteraceae) in Mice

Anxiolytic-Like Effect of Methanol Leaf Extract of Laggera aurita Linn. F. (Asteraceae) in Mice

Anticonvulsant, Muscle Relaxant and In-Vitro Antioxidant Activities of Hydroethanol Leaf Extract of Costus afer Ker Gawl (Costaceae) in Mice

Effect of 70% Ethanol Extract and its Solvent Fractions of Artemisia afra (Jacq. Ex Willd.) against Pentylenetetrazole-Induced Seizure in Mice

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