Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds

Dimmock, Jonathan R.; Vashishtha, S. C.; Stables, James P.

doi:10.1016/s0223-5234(00)00123-9

Cited by 252 publications

(152 citation statements)

References 12 publications

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“…Hydrazones are an emerging class of materials, which have been demonstrated to possess awide range of biological and pharmaceutical activities such as antimicrobial, anti-convulsant, antifungal,anticancer, antitubercular, antiviral,antibacterial, and antioxidant activities [1][2][3][4][5][6][7][8].M eanwhile,h ydrazones have also interesting properties because of the presence of several coordinations ites,a nd thus theirm etal complexes are important for their possible biological applications [9].T he thiazole ring is present in various biologically active molecules. Thiazoles and their derivatives possessa ctivities such as antitumor, antiviral, and antibacterial [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Zhang

2015

Zeitschrift Für Kristallographie - New Crystal Structures

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Section: Discussionmentioning

confidence: 99%

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Zhang

2015

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Hydrazones are an emerging class of materials, which have been demonstrated to possess a wide range of biological and pharmaceutical activities such as antimicrobial [1], anti-convulsant [2], antifungal [3], anticancer [4], antitubercular [5], antiviral [6], antibacterial [7], and antioxidant [8] activities. Meanwhile, hydrazones have also interesting properties because of the presence of several coordination sites, and thus their metal complexes are important for their possible biological applications [9].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 1-(propan-2-ylidene)-2-(thiazolo[5,4-b]pyridin-2-yl)- hydrazine, C9H10N4S

Guo

Miao

2013

Zeitschrift Für Kristallographie - New Crystal Structures

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Source of materialThe title compound was obtained from 2-amin-3-chloropyridine according to the literature method [14]. Single crystals suitable for X-ray diffraction were obtained by crystallization of the title compound from methanol. Experimental detailsAll of the non-hydrogen atoms were refined anisotropically. The hydrogen atoms were assigned with common isotropic displacement factors U iso (H) = 1.2U eq (N and pyridine C), or U iso (H) = 1.5U eq (methyl C) and included in the final refinement by using geometrical restraints, with C-H = 0.93 Å (pyridine) or C-H = 0.96 Å (methyl), and N-H = 0.86 Å. 12]. In this paper we report the synthesis and crystal structure of a novel thiazolehyrazone compound. The asymmetric unit contains one molecule of the title compound, which is constructed by the pyridinethiazole moiety, the hydrazone linker, and the bimethyl moiety. Discussion

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“…Compounds 16,19, and 33 offered 66% protection. Compounds 8,9,10,12,13,15,16,17,19,20,25,26,27,28,30,32,33, and 35 showed moderate protective effect in the MES and compounds 11, 18, and 31 were found to be 100% protective. Majority of the compounds, except 22,23,24,29,34, and 36, were active in MES tests making them useful for a broad spectrum of seizure types.…”

Section: Pharmacologymentioning

confidence: 97%

“…Hence, there is an increase in anticonvulsant activity by our molecular modifications in the sulfonamide and amide series anticonvulsants. Dimmock et al [31,32] has proposed a binding site hypothesis for these compounds eliciting anticonvulsant activity.…”

Section: Pharmacologymentioning

confidence: 99%

Synthesis and Evaluation of 3‐[(2,4‐Dioxo‐1,3,8‐triazaspiro[4.6]undec‐3‐yl)methyl]benzonitrile Derivatives as Potential Anticonvulsants

Madaiah

Prashanth

Revanasiddappa

et al. 2013

Archiv der Pharmazie

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New 3- [(2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl)methyl]benzonitrile derivatives 8-37 were synthesized and their pharmacological activities were determined with the objective to better understand their structure-activity relationship (SAR) for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) and pentylenetetrazole (PTZ) test. Compounds 11, 18, 31, and 32 showed significant and protective effect on seizure, when compared with the standard drug valproate. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drug. From this study, it is quite apparent that there are at least three parameters for the activity of anticonvulsant drugs, that is, a lipophilic domain, a hydrophobic center, and a twoelectron donor.

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Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds

Cited by 252 publications

References 12 publications

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Crystal structure of 1-(propan-2-ylidene)-2-(thiazolo[5,4-b]pyridin-2-yl)- hydrazine, C9H10N4S

Synthesis and Evaluation of 3‐[(2,4‐Dioxo‐1,3,8‐triazaspiro[4.6]undec‐3‐yl)methyl]benzonitrile Derivatives as Potential Anticonvulsants

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