Anticonvulsants Normothymics: Prognosis of Efficacy

Abstract

Cerebeolysin (EBEWEAusuia)has a neurotrophic and antioxidant effect an is used for treating protractedextrapyramidal complications resulting fromneuroleptic therapy(tardivedyskinesia, parkinsonism). 30 patients withendogenouspsychoses(schizophrenia, shizoaffective and affective ps)d1osis)werestudied who developedtardivedyskinesia (10 patients). parkinsonism (II patients)and a combination of tardivedyskinesia and parkinsonism (9 subjects). During registration of neuroleptic complications. standard scales were used • ESRS. AIMS. SARS. Cerebrolysin was presecribedi,v. drop infusions everyother day for 28 days. The dosage was made up 5.Q.IO.0. It was found to be equally effective in treating both tardive dyskinesia (responders 60%. partial responders 20%) and parkinsonism (responders 54% and partial responders 18%). Therapeutic efficacydecreasedin combination tardive dyskinesia and parkinsonism (responders 22.2%. partial responders 44.4%). Treatment withcerebrolysin reduced extrapyramidal symptoms and reduced the severity of other adverse effects of the use of psychotropicdrugs.