Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats

Hsieh, Ching Liang; Chang, Chiung‐Wen; Chiang, Su‐Yin; Li, Tsai‐Chung; Tang, Nou Ying; Pon, Chu Zong; Hsieh, Ching Tou; Lin, Jaung Geng

doi:10.1016/s0024-3205(00)00706-2

Cited by 73 publications

(42 citation statements)

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“…Liu and Mori (1993) showed that vanillic acid has superoxide and hydroxyl radical scavenging activities, which assist in terminating lipid peroxidation. Vanillyl alcohol has been shown to play a critical role in the free radical scavenging activities of Gastrodia, a traditional Chinese herb (Hsieh et al 2000).…”

Section: Abts +• Scavenging Activitymentioning

confidence: 99%

Reactivity of phenolic compounds towards free radicals under in vitro conditions

2015

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The free radical scavenging activity and reducing power of 16 phenolic compounds including four hydroxycinnamic acid derivatives namely ferulic acid, caffeic acid, sinapic acid and p-coumaric acid, benzoic acid and its derivatives namely protocatechuic acid, gallic acid and vanillic acid, benzene derivatives namely vanillin, vanillyl alcohol, veratryl alcohol, veratraldehyde, pyrogallol, guaiacol and two synthetic antioxidants, butylated hydroxy anisole (BHA) and propyl gallate were evaluated using 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH • ), 2,2′-Azinobis-3-ethylbenzothiazoline-6-sulfonic acid radical (ABTS +• ), Hydroxyl radical ( • OH) and Superoxide radical (O 2•-

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Section: Abts +• Scavenging Activitymentioning

confidence: 99%

Reactivity of phenolic compounds towards free radicals under in vitro conditions

2015

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“…With a dose between 6 g/60 kg/day, the in vivo toxicity of GEB did not affect any morphological changes in tissue level (data not shown). It has been determined that GEB extracts exhibited potent anti-oxidant activity (1,18).…”

Section: Resultsmentioning

confidence: 99%

“…It has been used as an anticonvulsant, analgesic and sedative to combat vertigo, hypertension, general paralysis and tetanus. Vanillyl alcohol and gastrodin, derived from GEB are known to have anticonvulsive actions (1). Recently, it was reported that compounds found in GEB inhibited glutamate-induced apoptosis in neuronal cells (2).…”

Section: Introductionmentioning

confidence: 99%

Anti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway

Heo

Woo²,

Son³

et al. 2007

Oncol Rep

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Abstract. Gastrodia elata Blume (GEB) is an important medicinal plant in Korea. In order to confirm the anti-tumor activities of GEB extracts, we carried out various in vitro antitumor assays, including a wound assay and an invasion assay using an ethyl ether extract of GEB. The results showed that the GEB extract exhibits potent anti-tumor activity in vitro in a dose-dependent manner. The expression of CD44, cdc42, Timp-2 or RhoA mRNA did not change by GEB treatment, compared to that of the control. GTP-Ras, an active form of a G-coupled protein family, however, is associated with the anti-tumor activity of GEB extracts. We examined various molecular markers related to metastasis by reverse transcriptase-polymerase chain reaction with the extract of GEB-treated B16 cells. There was an increase in GTP-Ras expression by the Gastrodia elata Blume extract. Together, these results suggest that the Gastrodia elata Blume extract could have potential in alleviating tumorigenesis, by a GTPRas-dependent pathway; although the precise molecular mechanisms are still being examined. IntroductionGastrodia elata Blume (GEB) is a traditional herb that has been used in East Asian for centuries. It has been used as an anticonvulsant, analgesic and sedative to combat vertigo, hypertension, general paralysis and tetanus. Vanillyl alcohol and gastrodin, derived from GEB are known to have anticonvulsive actions (1). Recently, it was reported that compounds found in GEB inhibited glutamate-induced apoptosis in neuronal cells (2). In addition, after pentylenetetrazole-induced seizure activity, the ether fraction of GEB has been shown to attenuate a decrease in γ-aminobutyric acid (GABA) and an increase in glutamate content, as well as having anticonvulsant effects (3).GEB is also used as sub-material for food or food-related industry. In 2001, the Korea Food and Drug Administration approved that GEB extracts as food ingredients; however, an in vivo toxicological study is still needed to determine its safety in food. We have already reported that GEB powersupplemented (0.5-1.0%) dough had a membrane-like structure that was more developed than that of the control, resulting in increased bread volumes (4). These results suggest that bread baked with 0.5-1.0% GEB exhibited an increase in loaf volume due to the more complete development of a gluten matrix.In our study, we determined that GEB protected cell damage by ß-amyloid in neuroblastoma cells (5). The ethyl ether fraction of GEB has potent activity toward ß-amyloidinduced cell damage via reducing caspase-3 activity (6,7; data not shown). In the course of a mechanistic study of the methanolic extract of GEB, we found that it has potent antitumor activity in vitro. The major finding of this report is that GEB exhibits anti-metastatic activities which were confirmed by wound and invasion assay in B16 melanoma cells. We further demonstrated that GEB increased anti-tumor activity via a GTP-Ras-dependent pathway. Materials and methodsCell culture. A murine melanoma cell line B16-F1 (B16; Ca...

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“…42 Herbal therapies used to treat convulsive diseases in Asia in modern times include Chai-Hu-Long-Ku-Mu-Li-Tan (TW-001), a mixture of extracts from 13 herbal therapies; Gastrodia elata (Tian Ma; gastrodia root); Uncaria rhynchophylla (cat's claw); Menispermum dauricum (moonseed); Shitei-To, a mixture of extracts from three medicinal herbs, Shitei (kaki calyx; the calyx of Diospyros kaki persimmon), Shokyo (gingerroot; rhizome of Zingiber officinale), and Choji (clove; pharmaceutical name, caryophylli flos; the flowerbud of Syzygium aromaticum); mixture of radish (Raphanus sativus) and pepper (Piper species, containing the alkaloid piperine); Qingyangshen (root of Cynanchum otophyllum); Kanbaku-taiso-to, a mixture of three herbal drugs, glycyrrhizae radix (licorice root; Glycyrrhiza species), tritici semen (wheat seed; Triticum aestivum), and zizyphi fructus (spiny jujube fruit; Ziziphus spinosa); paeoniae radix (peony root; Paeonia lactiflora, synonym P. albiflora); and Zheng Tai instant powder (a complex prescription of traditional Chinese medicines used for tonic-clonic seizures). 43 Several of these herbal therapies have been shown to have neuroprotective properties, [44][45][46] efficacy in animal models of epilepsy [47][48][49] and hippocampal slice models, 50 and effects on gene expression. 51 These studies generally do not specify, however, the methods used to 1) authenticate the source plants, 2) produce extracts and fractions, 3) characterize the active ingredients, or 4) perform the preclinical evaluations.…”

Section: Herbal Therapies For Epilepsymentioning

confidence: 99%

Botanicals and Herbs: A Traditional Approach to Treating Epilepsy

Schachter

2009

Neurotherapeutics

119

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Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats

Cited by 73 publications

References 0 publications

Reactivity of phenolic compounds towards free radicals under in vitro conditions

Reactivity of phenolic compounds towards free radicals under in vitro conditions

Anti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway

Botanicals and Herbs: A Traditional Approach to Treating Epilepsy

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