Anticonvulsive effect of p-chlorophenylalanine in audiosensitive mice

Alexander, George J.; Kopeloff, Lenore M.; Alexander, Rita B.

doi:10.1016/0024-3205(71)90159-7

Cited by 22 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The daily rhythm of susceptibility to high oxygen pressure seizures appears to be related to the daily rhythm of norepinephrine levels in the hypothalamus and brain stem (Hof et at., 1972), and drug-induced alteration of the metabolism of biogenic amines also modifies the convulsant effect of high oxygen pressure . Brain norepinephrine and serotonin have been implicated in the mechanisms of audiogenic seizures (Jobe et at., 1973;Alexander et at., 1971;Lehman, 1967;Schlesinger and Schreiber, 1969), in which the GABA mechanisms may well playa role (Pasquini et at., 1968).…”

Section: Pharmacological Relationships Between Biogenic Amines and Gabamentioning

confidence: 99%

Biochemical Pharmacology of GABA in CNS

Tapia

1975

Amino Acid Neurotransmitters

View full text Add to dashboard Cite

Section: Pharmacological Relationships Between Biogenic Amines and Gabamentioning

confidence: 99%

Biochemical Pharmacology of GABA in CNS

Tapia

1975

Amino Acid Neurotransmitters

View full text Add to dashboard Cite

“…However, our results contrast with few previous reports suggesting anticonvulsant effects of PCPA. For instance, acute PCPA treatments reduced audiogenic seizures in mice and prevented seizure development by amygdala stimulation in rats, 19,33 and chronic treatment with PCPA retarded the development of bioelectrical and behavioral seizure phenomena in rabbits. 34 It is possible that 5-HT affects seizures differentially in various models that require investigations.…”

Section: Discussionmentioning

confidence: 99%

“…16,17 However, SSRIs that increase synaptic 5-HT previously were also thought to reduce seizure threshold and promote seizure occurrence. 18,19 Majority of reports, however, points toward their anti-convulsant role and that SSRIs are well-tolerated in patients with epilepsy. 20 Thus, the depletion of serotonin concentrations in the brain was reported to increase seizure susceptibility and to decrease seizure threshold in several animal models of epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Serotonergic mechanisms in the 6-Hz psychomotor seizures in mice

2018

View full text Add to dashboard Cite

Serotonin (5-hydroxytrytamine (5-HT)) plays an important role in experimental seizures. Recently, we reported the depletion of 5-HT by parachlorophynylalanine (PCPA) in whole brain to enhance 6-Hz psychomotor seizures in mice. In the present work, we investigated the effect of 5-HT depletion in cortex and hippocampus, brain regions relevant for epilepsy, on behavioral and ultra-structural changes following 6-Hz psychomotor seizures in mice. In addition, we studied the effect of sodium valproate (SVP) on behavioral, biochemical, and ultra-structural effects induced by 6 Hz. Behavioral changes induced by 6 Hz stimulation were characterized as the increased duration of Straub’s tail, stun position, twitching of vibrissae, forelimb clonus, and increased rearing and grooming. PCPA administration further enhanced while SVP reduced these behaviors in mice. The 6-Hz psychomotor seizure induced ultra-structural changes in both cortex and hippocampus in mice treated with PCPA. Furthermore, PCPA administrations followed by 6Hz-induced seizures were accompanied by reduced hippocampal and cortical 5-HT. SVP attenuated the PCPA-induced ultra-structural changes and alterations of 5-HT content in the mouse brain. The study suggests the involvement of 5-HT in the 6 Hz psychomotor seizures and in the mechanisms of action of SVP against such seizures in mice.

show abstract

“…We (14) previously reported that midbrain raphe nuclei lesions did not have any effect on the formation of either hippocampal or amygdaloid kindling. Furthermore, the effect of 5-HT depletions on seizures using various seizure models have been somewhat ambiguous (20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%