Anticyclic Citrullinated Peptide Antibody and Rheumatoid Factor in South Tunisian Patients With Rheumatoid Arthritis: Association With Disease Activity and Severity

Hamad, Mariem Ben; Marzouk, S.; Kaddour, N.; Masmoudi, Hatem; Fakhfakh, Faiza; Rebai, Ahmed; Bahloul, Z.; Maalej, Aref

doi:10.1002/jcla.21638

Cited by 13 publications

(8 citation statements)

References 42 publications

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“…Likewise among the clinical laboratory findings, both the presence of RF and erosions were found to be associated with RA. Similar findings have been cited in the literature that higher ACCP levels are associated with progressive and erosive joint damage [11][12][13][14][15].…”

Section: Discussionsupporting

confidence: 89%

Anti- Cyclic Citrullinated Peptide Antibodies: Clinical utility and their role as early prognostic markers in Erosive Rheumatoid Arthritis.

Aniyappanavar¹,

Shruthi²,

Rajendran³

2015

Int Jour of Biomed Res

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Objectives: To assess the diagnostic utility of anti-cyclic citrullinated protein antibody (anti-CCP) in comparison to rheumatoid factor (RF) in diagnosis of rheumatoid arthritis (RA) and to determine its prognostic value in erosive rheumatoid arthritis. Materials and Methods:The study included 60 patients with clinically suspected RA. Anti-CCP was measured by enzyme-linked immunosorbent assay (ELISA) and rheumatoid factor (RF) by nephalometry. The seropositivity with RF and ACCP antibodies were studied in comparison with radiographic changes and joint symptoms which included presence and duration of joint involvement-multiple joints, small joints, symmetric joints, stiffness or swelling of joints. Results: Among the 60 patients, the mean age for RA was found to be 43 years. A higher seropositivity was found among the females. The sensitivity and specificity of anti-CCP reactivity for the diagnosis of RA were 38.3 and 100 respectively. Among the symptoms studied, small joint involvement and involvement of multiple joints showed a positive association with serologically positive individuals. Patients with high anti-CCP antibody titres showed higher RF titres and severe radiographic erosions. Conclusion: Anti CCP antibodies are highly specific for rheumatoid arthritis. A combined diagnosis using both high titers of anti-CCP antibodies and a positive RF test markedly improves RA diagnostic specificity. ACCP antibody detection helps in early diagnosis as well as detection of progressive joint damage.

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Section: Discussionsupporting

confidence: 89%

Anti- Cyclic Citrullinated Peptide Antibodies: Clinical utility and their role as early prognostic markers in Erosive Rheumatoid Arthritis.

Aniyappanavar¹,

Shruthi²,

Rajendran³

2015

Int Jour of Biomed Res

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“…However, joint pain is often present before the onset of joint inflammation, a time when autoantibodies are also detected [20], suggesting a possible link between the two, irrespective of clinical inflammation. In agreement with a role in joint pain, one study showed that the presence of ACPAs positively correlated with pain scores [21].…”

Section: Key Pointsmentioning

confidence: 89%

Autoantibodies and pain

Dawes

Vincent²

2016

Current Opinion in Supportive &Amp; Palliative Care

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“…Abnormal levels of RF and anti-CCP antibodies indicate that the patient has a severe condition with a rapid progression, as well as severe bone destruction. 16 This indicates that IL-37 levels have a distinct correlation with the severity of RA.…”

Section: Discussionmentioning

confidence: 97%

Detection of IL-37 in peripheral blood of patients with rheumatoid arthritis and its clinical significance

Huang

Wang

2019

Eur J Inflamm

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The study aimed to detect the expression level of interleukin-37 (IL-37) in patients with rheumatoid arthritis (RA) and explore its clinical significance. A total of 40 peripheral blood samples from active and stable RA patients were collected (40 patients with RA), and peripheral blood from 40 healthy volunteers was used as the control group. Peripheral blood serum and peripheral blood mononuclear cells (PBMCs) were isolated. The expression of IL-37 mRNA in PBMCs was detected by real-time fluorescence quantitative PCR. Serum levels of IL-37, rheumatoid factor (RF), and anticyclic citrullinated peptide antibody (CCP) were measured by enzyme-linked immunosorbent assay (ELISA). The results were then calculated and analyzed. The results showed that expression of IL-37 mRNA in the PBMCs of patients with RA was significantly higher than that in the control group (P < 0.05). Expression of IL-37 mRNA in the PBMCs of the active period group was significantly higher than that in the stable period group (P < 0.05). IL-37 levels in patients with RA were significantly higher than those of the control group (P < 0.05). IL-37 levels in the active period group were also significantly higher than those of the stable period group (P < 0.05). The comparative analysis of RF and anti-CCP antibody levels showed that IL-37 was positively correlated with RF and anti-CCP levels in patients with RA. In conclusion, the expression level of IL-37 in peripheral blood of RA patients was significantly higher than that of normal control group, and it was correlated with RF and CCP antibody levels, indicating that IL-37 plays an important role in the development of RA.

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Anticyclic Citrullinated Peptide Antibody and Rheumatoid Factor in South Tunisian Patients With Rheumatoid Arthritis: Association With Disease Activity and Severity

Abstract: These findings suggest that anti-CCP antibodies are associated with RF and more severe joint damage. Moreover, disease activity is associated with functional disability.

Cited by 13 publications

References 42 publications

Anti- Cyclic Citrullinated Peptide Antibodies: Clinical utility and their role as early prognostic markers in Erosive Rheumatoid Arthritis.

Anti- Cyclic Citrullinated Peptide Antibodies: Clinical utility and their role as early prognostic markers in Erosive Rheumatoid Arthritis.

Autoantibodies and pain

Detection of IL-37 in peripheral blood of patients with rheumatoid arthritis and its clinical significance

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