Antidepressant Action of Atypical Antipsychotics

Bilateral Pedal Edema After Desvenlafaxine Therapy

“…Pedal edema had been reported after the use of psychotropic agents. The available reports mostly include mirtazapine, escitalopram, venlafaxine, and trazodone combination, olanzapine, risperidone, and quetiapine 2,4–6,11 . The common mechanisms involved in drug-associated edema's pathogenesis are increased capillary permeability, lymphatic drainage disruption, renal fluid balance, and vasodilation 2 .…”