Antidepressant Activity of Alcoholic Extract of the Fruits of Osmanthus fragrans Lour in Mice

Jawaid, Talha; Gupta, Roli; Rahman, Md. Azizur; Kamal, Mehnaz

doi:10.3923/rjmp.2015.187.193

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Modern research shows that Osmanthus fragrans seeds contain a lot of active chemical components ( Wang et al, 2006 ; Pan et al, 2009 ; Yin et al, 2013 ; Liao et al, 2018 ; Liao et al, 2019 ), such as iridoid glycosides, salidroside, oleanolic acid, ursolic acid, flavonoids, and volatile oil. Among them, iridoid glycosides are the landmark components of Oleaceae plants ( Jensen et al, 2002 ), which have a variety of biological activities such as anti-inflammatory and analgesic, hepatoprotective and cholagogic, bacteriostatic, sedative, antihypertensive, and antitumor ( Huang et al, 2011 ; Jawaid et al, 2015 ; Ouyang et al, 2015 ; Tang et al, 2015 ). Additionally, there are about 10 kinds of iridoid glycosides that have been isolated from Osmanthus fragrans seeds, including nuezhenoside, specnuezhenide, isonuezhenide, nuezhenoside G13, oleoside, oleoside dimethyl ester, and strychnine glycosides, among which the contents of specnuezhenide, isonuezhenide, and nuezhenoside G13 are higher ( Yang et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

The Potential Protective Effect of Iridoid Glycosides Isolated From Osmanthus fragrans Seeds Against the Development of Immune Liver Injury in Mice

et al. 2021

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Objective: The iridoid glycosides were extracted and separated from Osmanthus fragrans seeds, and the potential protective effect of Osmanthus fragrans seed extract on concanavalin A-induced immune liver injury in mice was studied.Methods:Osmanthus fragrans seeds were extracted by 95% ethanol reflux. Then, the iridoid glycosides were enriched by extraction refined through petroleum ether (60°C–90°C), ethyl acetate, and water-saturated n-butanol in sequence, so as to purify the n-butanol part (Osmanthus fragrans seed’s n-butanol extraction, OFSN) by macroporous resin. Specnuezhenide and Nuezhenoside G13 were used as the reference substances to determine the concentration of iridoid glycosides by HPLC. On this basis, a mouse immune liver injury model was established by tail intravenous concanavalin A (20 mg/kg); the contents of serum ALT, AST, IFN-γ, and TNF-α and the contents of liver tissue MDA and SOD were determined; the pathological changes of the liver by HE staining were observed; and the expression levels of p38MAPK and p-p38mapk in liver tissue were detected by WB.Results: The linearity, precision, repeatability, recovery, and stability of HPLC all met the requirements by validating with the methodology. The contents of Specnuezhenide and Nuezhenoside G13 in the n-butanol extracts were 39.20% and 39.88%, respectively. Actually, their contents can reach up to 82.56% and 87.9% after being purified by macroporous resin. The results of animal experiments show that OFSN could significantly reduce the liver and spleen index, reduce the ALT and AST contents in plasma and the MDA content in liver tissue, and then increase the SOD content. Besides, OFSN could also reduce the plasma IFN-γ and TNF-α levels. The HE staining result indicates that the pathological changes in the liver tissues of mice treated with OFSN are alleviated to different degrees while the WB result suggests that OFSN could significantly inhibit the expression of p-p38mapk.Conclusion:Osmanthus fragrans seeds are rich in iridoid glycosides, which has a good protective effect on mouse immune liver injury caused by concanavalin A. The mechanism may be related to inhibiting the phosphorylation of p38MAPK, inhibiting the release of inflammatory mediators, improving the antioxidant capacity of liver cells, and weakening the occurrence of lipid peroxidation.

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Section: Introductionmentioning

confidence: 99%

The Potential Protective Effect of Iridoid Glycosides Isolated From Osmanthus fragrans Seeds Against the Development of Immune Liver Injury in Mice

et al. 2021

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The ethanolic extract of Osmanthus fragrans var. thunbergii flowers ameliorates depressive‐like behaviors of mice by modulating the serotonin system and suppressing neuroinflammation

Luo,

Xue,

Wang

et al. 2024

Food Science & Nutrition

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It is crucial to explore the impact of dietary interventions on depression and develop functional antidepressant foods, due to the significant side effects and poor treatment compliance of antidepressant drugs. Osmanthus fragrans flowers are edible and medicinal materials owing to their delightful floral aroma and significant health benefits. Here, we evaluated the antidepressant effects of the ethanolic extract of O. fragrans var. thunbergii flowers (OFE) and investigated the mechanisms of action on the serotonin system and neuroinflammation, and analyzed the main chemical components of OFE. A single administration of OFE significantly reduced the immobility duration in the forced swimming and tail suspension tests in mice without affecting locomotor activity. OFE exhibited selective enhancing effects on 5‐HTergic function in vivo, as demonstrated by its potentiating effects on 5‐hydroxytryptophan (5‐HTP)‐induced head‐twitch behavior and alleviation effects on reserpine‐induced ptosis deficits. In addition, OFE increased 5‐hydroxytryptamine (5‐HT) concentration and upregulated 5‐HT1A expression in reserpine‐treated mice, further validating its effects on 5‐HT transmission. Interestingly, OFE significantly alleviated microglia activation and the production of inflammatory mediators, both in reserpine‐treated mice in vivo and lipopolysaccharide (LPS)‐stimulated BV‐2 cells in vitro. Additionally, 62 components in OFE were identified using ultra‐performance liquid chromatography quadrupole time‐of‐flight high‐resolution mass spectrometry, and glycoside derivatives were shown to be the major constituents of OFE. The present study showed that OFE can alleviate depressive‐like behaviors by modulating the serotonin system and reducing neuroinflammation. These results suggest that OFE can be valuable dietary supplements with therapeutic effects on depression.

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Natural products and their active principles used in the treatment of neurodegenerative diseases: a review

Kamal

Naz

Jawaid

et al. 2019

Orient Pharm Exp Med

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Antidepressant Activity of Alcoholic Extract of the Fruits of Osmanthus fragrans Lour in Mice

Cited by 4 publications

References 18 publications

The Potential Protective Effect of Iridoid Glycosides Isolated From Osmanthus fragrans Seeds Against the Development of Immune Liver Injury in Mice

The Potential Protective Effect of Iridoid Glycosides Isolated From Osmanthus fragrans Seeds Against the Development of Immune Liver Injury in Mice

The ethanolic extract of Osmanthus fragrans var. thunbergii flowers ameliorates depressive‐like behaviors of mice by modulating the serotonin system and suppressing neuroinflammation

Natural products and their active principles used in the treatment of neurodegenerative diseases: a review

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