Antidepressant and Neuroprotective Effects of Naringenin via Sonic Hedgehog-GLI1 Cell Signaling Pathway in a Rat Model of Chronic Unpredictable Mild Stress

Tayyab, Mohd; Farheen, Shirin; M, Mubeena Mariyath P; Khanam, Nabeela; Hossain, Mohammad Salim; Shahi, Mehdi H.

doi:10.1007/s12017-019-08538-6

Cited by 40 publications

(22 citation statements)

References 53 publications

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“…No difference in the total distance traveled was seen among all groups, suggesting that locomotor activity has been affected neither by CIS nor HECO. These results are consistent with behavioral data from other studies showing no effect of chronic stress or anxiolytic treatment on locomotor activity (Dhamija, Parle, & Kumar, 2017; Jiang et al, 2018) while some studies (Mehta et al, 2017; Tayyab et al, 2019; Wang, An, & Zhang, 2008) reported decreased locomotor activity in stressed animals comparing to treated one. The reason for this discrepancy may relate to the use of different strains of animals, the open field arena dimensions, chronic stress procedures, and drugs.…”

Section: Discussionsupporting

confidence: 90%

“…Several studies have been suggested that traditional herbal medicine, dietary fruit, and vegetable supplementation may be effective as alternative treatments for depression. Popular compounds abundantly present in natural plants, such as curcumin (Xu et al, 2007), resveratrol (Liu et al, 2016), proanthocyanidin (Xu et al, 2010), blueberry polyphenols (Casadesus et al, 2004), naringenin (Tayyab, Farheen, Khanam, Hossain, & Shahi, 2019), and quercetin (Mehta, Singh, & Udayabanu, 2017), have been shown to improve the symptoms of depression and deficits in learning and memory by affecting the hippocampal region with different molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats

Sakhri

Adachi

Zerizer

et al. 2020

Phytotherapy Research

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It is known that chronic stress is a contributing factor to several physical and mental diseases. In this study, we examined the effect of hydroethanolic extract of Cydonia oblonga fruit (HECO, 300 mg/kg) in chronically immobilized rats on physiological and behavioral parameters by the open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST) and on neurological alterations by analysis of the hippocampal neurogenesis. A daily 6 hr exposure to chronic immobilization stress (CIS) for 21 consecutive days induced anxiety‐ and depressive‐like behaviors in rats' concomitant with decreased weight gain and increased plasma corticosterone (CORT) levels, rats also showed atrophy in the CA3 subregion of the hippocampus and a decreased number of Ki67 and DCX positive cells in the dentate gyrus (DG). Treatment with HECO successfully suppressed the physiological and behavioral markers of the CIS and prevents the structural abnormality and the impaired cell proliferation in the hippocampus. Moreover, the daily administration of HECO improved the mood function in normal rats. Taking together, our findings demonstrate, for the first time, the anti‐depressive effect of C. oblonga fruit by enhancing the hippocampal neurogenesis in the rat model of depression.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats

Sakhri

Adachi

Zerizer

et al. 2020

Phytotherapy Research

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“…These behavioral changes correlate with the core symptoms of depression such as anhedonia, despair, and loss of interest, respectively. The CUMS model is commonly used for assessment of antidepressant effects of various therapeutic interventions (8)(9)(10). Notably, emerging evidence indicates that animals exposed to chronic stress exhibit metabolic abnormalities including insulin resistance, glucose intolerance, and hyperlipidemia (11), which is in agreement with the clinical reports that stress related depression is highly comorbid with diabetes.…”

Section: Introductionsupporting

confidence: 61%

Susceptibility to Hyperglycemia in Rats With Stress-Induced Depressive-Like Behavior: Involvement of IL-6 Mediated Glucose Homeostasis Signaling

Qiu

et al. 2020

Front. Psychiatry

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Depression is a common psychiatric disorder comorbid with diabetes and may lead to high morbidity, disability, and mortality. However, the underlying mechanism behind their association remains unknown. Cytokine-mediated inflammation in brain may play important roles in the pathogenesis of depression and insulin resistance. In the present study, we subjected the rats to chronic unpredictable mild stress (CUMS) for 3 to 8 weeks. The tests to ascertain depression-like behaviors including open field test (OFT) and forced swimming test (FST) were performed, and levels of morning fasting blood glucose, triglyceride (TG), total cholesterol (CHOL), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C), body weight, food intake, histopathological examinations of liver, adipose tissues and hypothalamus, hypothalamic GLUT4 as well as the IL-6-mediated glucose homeostasis signaling pathway were measured. The results showed that CUMS exposure resulted in the depression-like behavior at various time points in rats. Moreover, the rats exhibited increased peripheral glucose levels, impaired hepatocytes and hippocampal neurons, and decreased hypothalamic GLUT4 levels after 6 weeks of CUMS exposure. Meanwhile, activated IL-6 but suppressed IL-6-mediated glucose homeostasis signaling was observed in the hypothalamus. Markers of lipid metabolism including TG, CHOL, HDL-C and LDL-C were dysregulated, and body weight and food intake were decreased in the CUMS-exposed rats. Our results show that depressed rats induced by 6-week CUMS stimulation display susceptibility to hyperglycemia, which is associated with IL-6-mediated inhibition of glucose homeostasis signaling in the hypothalamus.

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“…The mechanism of EA to treat PSD is to suppress inflammation and oxidative stress through activation of the Shh‐signalling pathway 103 . Studies have shown that naringenin via Sonic hedgehog‐Gli1 cell signalling pathway has antidepressant and neuroprotective effects 104 . It has been proved that chronic unpredictable mild stress induced depression results decided expression of brain derived neurotrophic factor (BDNF), Wnt/β‐Catenin, Shh and its downstream transcription factors Gli1/2/3 and Nkx2.2 in the hippocampus 105 .…”

Section: Effect Of Shh Signal Pathway On Cnsmentioning

confidence: 99%

The role of Shh signalling pathway in central nervous system development and related diseases

et al. 2020

Cell Biochemistry & Function

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Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is essential for pattern formation, cell‐fate specification, axon guidance, proliferation, survival and differentiation of neurons in CNS development. The abnormal signalling pathway of Shh leads to the occurrence of many nervous system diseases. The mechanism of Shh signalling is complex and remains incompletely understood. Nevertheless, studies have revealed that Shh signalling pathway is classified into canonical and non‐canonical pathways. Here we review the role of the Shh signalling pathway and its impact in CNS development and related diseases. Specifically, we discuss the role of Shh in the spinal cord and brain development, cell differentiation and proliferation in CNS and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. We also highlight future directions of research that could help to clarify the mechanisms and consequences of Shh signalling in the process of CNS development and related diseases. Significance of the study This review summarized the role of Shh signalling pathway in CNS development and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. It also presented the author's opinions on the future research direction of Shh signalling pathway.

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Antidepressant and Neuroprotective Effects of Naringenin via Sonic Hedgehog-GLI1 Cell Signaling Pathway in a Rat Model of Chronic Unpredictable Mild Stress

Cited by 40 publications

References 53 publications

Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats

Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats

Susceptibility to Hyperglycemia in Rats With Stress-Induced Depressive-Like Behavior: Involvement of IL-6 Mediated Glucose Homeostasis Signaling

The role of Shh signalling pathway in central nervous system development and related diseases

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