Antidepressant effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice

Almeida, Reinaldo Nóbrega de; Navarro, D S; Assis, T.S.; Medeiros, Isac A.; Thomas, George P.

doi:10.1016/s0378-8741(98)00086-5

Cited by 31 publications

(15 citation statements)

References 11 publications

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“…Prior to the application of synthetic antidepressant drugs, many traditional Chinese medicines and empirical formula were successfully used to treat the depression-like disorder by dispersing stagnant liver qi underlining the possibility that folk remedies could be an important source of new antidepressant drugs (Almeida et al, 1998;Luo et al, 2000). As a follow-up to our previous investigation of Banxia Houpu decoction, an ancient Chinese empirical formula (Luo et al, 2000), we expended our attention to Plantago asiatica L. (Plantaginaceae), Scrophularia ningpoensis Hemsl.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant effect of three traditional Chinese medicines in the learned helplessness model

Luo

Tan

2004

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Antidepressant effect of three traditional Chinese medicines in the learned helplessness model

Luo

Tan

2004

Journal of Ethnopharmacology

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“…PTZ-induced seizures test is considered as an experimental model for the "generalized absence seizures" (Oliveira et al, 2001). PTZ may cause seizures by inhibiting chloride ion channel associated with GABA A receptors (Löscher;Schmidt, 1988;Almeida et al, 1998;Ngo Bum et al, 2001). Furthermore, PTZ might induce convulsions by direct excitatory effect upon membranes or by an antagonism of the effect of endogenous benzodiazepine substances (Faingold, 1987).…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant properties of the total alkaloid fraction of Rauvolfia ligustrina Roem. et Schult. in male mice

Quintans‐Júnior¹,

Silva²,

Siqueira³

et al. 2007

Rev. bras. farmacogn.

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RESUMO: "Propriedades anticonvulsivantes da fração dos alcalóides totais de Rauvolfi a ligustrina Roem. et Schult. em ratos machos". Rauvolfi a ligustrina Roem. et Schult. (Apocynaceae) é uma planta amplamente distribuída no Nordeste Brasileiro, rica em alcalóides indólicos, conhecida popularmente como "paratudo" e "arrebenta-boi". O presente estudo buscou avaliar a dose letal 50 % (DL 50 ) da fração de alcalóides totais (FAT) das partes aéreas da R. ligustrina e a sua possível atividade anticonvulsivantes em roedores. A FAT apresentou uma DL 50 , via intraperitoneal (i.p.), de 127,8 (112,5-145,2) mg/kg e foi efetiva, na dose de 20 mg/kg (i.p.), em proteger os animais das convulsões induzidas pelo pentilenotetrazol (PTZ) e picrotoxina (PIC) aumentando signifi cativamente (p < 0,05) a latência para o aparecimento das convulsões, sendo um indicativo de um efeito anticonvulsivante.Unitermos: Rauvolfi a ligustrina, anticonvulsivante, pentilenotetrazol, picrotoxina, eletrochoque auricular.ABSTRACT: Rauvolfi a ligustrina Roem et. Schult (Apocynaceae), commonly known as "paratudo" and "arrebenta-boi" is a small tree found in Brazilian Northeastern. Previous studies have demonstrated depressant and anticonvulsant properties of the ethanol extract of Rauvolfi a ligustrina. The aim of the present study was the determination of the lethal dose 50% (LD 50 ) and the effects of total alkaloid fraction (TAF) of the aerial parts of R. ligustrina in animal models of convulsion. It was found that the acute toxicity of TAF was 127.8 (112.5-145.2) mg/kg (i.p.) in mice. TAF (20 mg/kg, ip) signifi cantly increased (p < 0.05) the latencies of clonic seizures induced by pentylenetetrazol (PTZ) and picrotoxin (PIC). However, TAF did not protect the animals in maximal electroshock (MES) induced seizures. These results suggest that TAF of R. ligustrina possesses anticonvulsant properties.

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“…Leucoanthocyanin biomolecules of the C. pareira have many biological effects, such as anticancer, antimicrobial and anti-infl ammatory effects (Savithramma et al 2011 ) . An ethanol extract of Cissampelos has been shown to have antidepressant-like effects in mice and rats (Almeida et al 1998 ) .…”

Section: Cissampelos Pareira Lmentioning

confidence: 99%

Contribution of Biotechnological Tools in the Enhancement of Secondary Metabolites in Selected Medicinal Climbers

Srivastava

Singh

Misra

2015

Biotechnological Strategies for the Conservation of Medicinal and Ornamental Climbers

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Plants by nature protect themselves by producing secondary metabolites which often have pronounced bioactivities. The presence of these metabolites is responsible for the active interaction of plants with their environment defending themselves against a variety of herbivores and pathogenic microorganisms as well as various kinds of abiotic stresses. Climber plants contain large number of useful secondary metabolites. Besides their pharmacological role, secondary metabolites also contain some other properties. Artabotrys hexapetalus , a climbing herb, secretes oil which is used in perfume industry. Capparis zeylanica is a thorny stout climbing shrub, used in the treatment of snake bite and to cure small pox, cholera, etc. Stem barks and roots of Tinospora cordifolia , a woody climber, are used in dysentery and diarrhoea. Toddalia asiatica , an evergreen climber, produced nitidine secondary metabolite which contains anti-HIV and antimalarial and anticancerous properties, but its production is not enough for commercial supply. Tissue culture technology has emerged as a supplementary branch to fulfi l demands for this valuable secondary metabolite. Various in vitro methods for enhancement of secondary metabolites are available such as hairy root culture, treatment of elicitors and use of precursors and introduction of any foreign gene via bacterial transformation.Current progresses have been made in the fi eld of molecular biology through the alteration in metabolic skeleton of plant secondary metabolism. With the use of various genes (involved in the synthesis of enzymes and their regulatory proteins), diverse pathways have been traced and being transformed. Antisense technology has been emerged as an additional alternative for enhancement of secondary metabolites. In Tylophora indica enhancement in kaempferol, an antioxidant compound was observed by using precursors like salicylic acid, ornithine, cinnamic acid, tyrosine and phenylalanine. The total dry weight of 2-hydroxy-4-methoxy benzaldehyde was enhanced in hairy root cultures of Decalepis hamiltonii . The present chapter provides an insight on the use of biotechnological techniques for the enhancement of secondary metabolites in medicinal climbers.

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Antidepressant effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice

Cited by 31 publications

References 11 publications

Antidepressant effect of three traditional Chinese medicines in the learned helplessness model

Antidepressant effect of three traditional Chinese medicines in the learned helplessness model

Anticonvulsant properties of the total alkaloid fraction of Rauvolfia ligustrina Roem. et Schult. in male mice

Contribution of Biotechnological Tools in the Enhancement of Secondary Metabolites in Selected Medicinal Climbers

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