Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route

Liu, Fei; Liu, You‐Ping; Liu, Gang; Liu, Peng; Chu, Zheng; Gao, Chengge; Dang, Yonghui

doi:10.18632/oncotarget.14356

Cited by 17 publications

(12 citation statements)

References 59 publications

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“…Brain issues were first weighed, then added normal saline according to a certain proportion (1 mg: 25 μl), homogenized by Soniprep (BioSpec Products, Inc., Bartlesville, USA), and supernatants were extracted after centrifugation. NMDAR1 and D2R levels were measured using a mouse enzyme-linked immuno-sorbent assay (ELISA) Kit (Shanghai Hushang Biotechnology, Shanghai, China) following standard procedures described in a previous study 15 . First, the prepared sample and the standard were placed in separate plate wells and incubated for 30 min at 37°C.…”

Section: Methodsmentioning

confidence: 99%

Social isolation induces schizophrenia-like behavior potentially associated with HINT1, NMDA receptor, and dopamine receptor 2

Liu

Chu

et al. 2017

NeuroReport

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Both genetic factors and early life adversity play major roles in the etiology of schizophrenia. Our previous studies indicated that social isolation (SI) during early postnatal development leads to several lasting abnormal behavioral and pathophysiological features resembling the core symptoms of some human neuropsychiatric disorders in mice. The glutamate and dopamine hypotheses are tightly linked to the development of schizophrenia. The cross-talk between glutamate N-methyl-d-aspartate acid receptors and dopamine receptors is associated with histidine triad nucleotide binding protein 1 (HINT1), which is correlated with diverse psychiatric disorders. We examined the effects of SI on schizophrenia-like behavior and used enzyme-linked immunosorbent assays to investigate the expression levels of HINT1, the NR1 subunit of N-methyl-d-aspartate acid receptor, and dopamine type 2 receptor (D2R) in C57 mice. We found that SI leads to a series of schizophrenia-related deficits, such as social withdrawal, anxiety disorder, cognitive impairments, and sensorimotor gating disturbances. These abnormal phenotypes paralleled changes of HINT1, NR1, and D2R. SI may be considered a robust model of the effects of early life stress on the schizophrenia-related behaviors in mice. Potential interactions among HINT1, NR1, and D2R may underlie the behavioral deficits induced by SI.

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Section: Methodsmentioning

confidence: 99%

Social isolation induces schizophrenia-like behavior potentially associated with HINT1, NMDA receptor, and dopamine receptor 2

Liu

Chu

et al. 2017

NeuroReport

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“…Moreover, NAP treatment prevents neuronal death often seen with clozapine, a commonly used anti-psychotic drug for treatment of schizophrenia (Merenlender–Wagner et al, 2014 ). Moreover, NAP reduces depressive-like behavior in mice following social isolation, exemplified by reduced immobility in the forced swim test and reduced anhedonic phenotype (Liu et al, 2017 ). NAP administration in DISC1 knockout mice, a model for schizophrenia, reduces anxiety levels in the elevated plus maze.…”

Section: Potential Benefit Of Nap For Treatment Of Psychiatric and Nementioning

confidence: 99%

Repositioning Microtubule Stabilizing Drugs for Brain Disorders

Varidaki

Yun

Coffey

2018

Front. Cell. Neurosci.

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Microtubule stabilizing agents are among the most clinically useful chemotherapeutic drugs. Mostly, they act to stabilize microtubules and inhibit cell division. While not without side effects, new generations of these compounds display improved pharmacokinetic properties and brain penetrance. Neurological disorders are intrinsically associated with microtubule defects, and efforts to reposition microtubule-targeting chemotherapeutic agents for treatment of neurodegenerative and psychiatric illnesses are underway. Here we catalog microtubule regulators that are associated with Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis, schizophrenia and mood disorders. We outline the classes of microtubule stabilizing agents used for cancer treatment, their brain penetrance properties and neuropathy side effects, and describe efforts to apply these agents for treatment of brain disorders. Finally, we summarize the current state of clinical trials for microtubule stabilizing agents under evaluation for central nervous system disorders.

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“…Accumulating evidence has shown that BDNF is implicated in the pathophysiology of depression and the antidepressant effects of exercise (Heyman et al, 2012;Archer et al, 2014;Lu et al, 2014). In addition, previous studies have suggested that neurotrophins such as NGF, NT-3, and NT-4/5 are important factors for neuroplasticity regulation, which have an important role in the neurotrophic hypothesis of antidepression (Pae et al, 2008;Overstreet et al, 2010;Hochstrasser et al, 2013;Lang and Borgwardt, 2013;Liu et al, 2017). The aim of this study was to examine the association between the neurotrophins and the antidepressant action of exercise intervention during METH abstinence.…”

Section: Introductionmentioning

confidence: 99%

Plasma BDNF and TrkB mRNA in PBMCs Are Correlated With Anti-depressive Effects of 12-Weeks Supervised Exercise During Protracted Methamphetamine Abstinence

Yang

Tan

Zheng

et al. 2020

Front. Mol. Neurosci.

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The aim of this study was to evaluate the potential neurotrophic factors and expression of neurotrophin receptors in peripheral blood mononuclear cells linked with the antidepressant action of exercise intervention during protracted methamphetamine (METH) abstinence. Materials and Methods: A total of 72 male METH addicts, including 47 individuals with depression and 25 individuals without depression, were recruited in this study. Individuals with depression were divided into the depression control group and the depression exercised group. Consequently, 12 weeks of supervised exercise intervention was applied. Depression and anxiety were analyzed; plasma brain-derived neurotrophic factor (BDNF), neuronal growth factor (NGF), neurotrophin-3 (NT-3), NT-4, and proBDNF levels were tested using enzyme-linked immunosorbent assay; the mRNA expressions of TrkA, TrkB-FL, TrkB-T1, TrkCB, and P75NTR in peripheral blood mononuclear cells were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Results: NT-4 plasma levels were correlated with depression (r = −0.330, p = 0.005), which remained significant after Bonferroni correction. In addition, the BDNF and NT-3 levels in the plasma were significantly correlated with depression (r = −0.268, p = 0.023; r = −0.259, p = 0.028), but did not reach significance after Bonferroni correction. The BDNF, NT-3, and NT-4 plasma levels were significantly different between the depressive control group and the depressive exercise group using pre-exercise values as the covariate. The fold changes in TrkB-FL and TrkB-T1 mRNA in peripheral blood mononuclear cells between the post-exercise and pre-exercise demonstrated a remarkable decrease (fold change = −11.056 and −39.055).

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Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route

Cited by 17 publications

References 59 publications

Social isolation induces schizophrenia-like behavior potentially associated with HINT1, NMDA receptor, and dopamine receptor 2

Social isolation induces schizophrenia-like behavior potentially associated with HINT1, NMDA receptor, and dopamine receptor 2

Repositioning Microtubule Stabilizing Drugs for Brain Disorders

Plasma BDNF and TrkB mRNA in PBMCs Are Correlated With Anti-depressive Effects of 12-Weeks Supervised Exercise During Protracted Methamphetamine Abstinence

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