Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop

Jiang, Chuan; Wang, Hua; Qi, Jiaying; Li, Jinghan; He, Qianqian; Wang, Chaonan; Gao, Yanni

doi:10.1007/s11011-022-01081-7

Cited by 3 publications

(1 citation statement)

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“…Moreover, the survival and apoptosis of neurons are related to the mechanism of the balance between Glu and GABA ( Engelbrecht et al, 2010 ). The glutamate/gamma-aminobutyric acid-glutamine metabolic circuit in the CNS is the main pathway that regulates the metabolism of Glu and GABA, which is important to maintain the dynamic balance between excitatory and inhibitory systems in the brain ( Jiang et al, 2022 ). During the metabolic conversion of Glu to GABA, excess Glu in the synaptic cleft can be eliminated or reduced through the excitatory amino acid transporters (EAATs) and GAD pathways.…”

Section: Gabaergic System and Ptsdmentioning

confidence: 99%

Involvement of the GABAergic system in PTSD and its therapeutic significance

Huang

Yang

et al. 2023

Front. Mol. Neurosci.

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The neurobiological mechanism of post-traumatic stress disorder (PTSD) is poorly understood. The inhibition of GABA neurons, especially in the amygdala, is crucial for the precise regulation of the consolidation, expression, and extinction of fear conditioning. The GABAergic system is involved in the pathophysiological process of PTSD, with several studies demonstrating that the function of the GABAergic system decreases in PTSD patients. This paper reviews the preclinical and clinical studies, neuroimaging techniques, and pharmacological studies of the GABAergic system in PTSD and summarizes the role of the GABAergic system in PTSD. Understanding the role of the GABAergic system in PTSD and searching for new drug targets will be helpful in the treatment of PTSD.

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Section: Gabaergic System and Ptsdmentioning

confidence: 99%