Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss

Kim, Yunna; Lee, Hwa Young; Choi, Yujin; Cho, Seung-Hun

doi:10.1016/j.jgr.2019.08.005

Cited by 19 publications

(10 citation statements)

References 48 publications

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“…For instance, ginsenosides Rg1, Rg3, Rh1, Rh3, Rb1, Rk1, and Rf from Panax ginseng C.A. Meyer have been demonstrated to exhibit dual actions against neuroinflammation and hyperactivation of the HPA axis [ 106 , 108 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 ], while 3,6’-disinapoyl sucrose and the oligosaccharide esters-enriched fraction, YZ50, from Polygala tenuifolia Willd have been shown to possess bioactivity that de-hyperactivates the HPA axis [ 216 , 217 , 218 ]. Additionally, poricoic acid A, isolated from Poria cocos (Schw.)…”

Section: Chm Effects On the Neuroendocrine-immune Networkmentioning

confidence: 99%

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Huang

Zhang

2021

Pharmaceuticals

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The neuroimmune and neuroendocrine systems are two critical biological systems in the pathogenesis of depression. Clinical and preclinical studies have demonstrated that the activation of the neuroinflammatory response of the immune system and hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis of the neuroendocrine system commonly coexist in patients with depression and that these two systems bidirectionally regulate one another through neural, immunological, and humoral intersystem interactions. The neuroendocrine-immune network poses difficulties associated with the development of antidepressant agents directed toward these biological systems for the effective treatment of depression. On the other hand, multidrug and multitarget Chinese Herbal Medicine (CHM) has great potential to assist in the development of novel medications for the systematic pharmacotherapy of depression. In this narrative essay, we conclusively analyze the mechanisms of action of CHM antidepressant constituents and formulas, specifically through the modulation of the neuroendocrine-immune network, by reviewing recent preclinical studies conducted using depressive animal models. Some CHM herbal constituents and formulas are highlighted as examples, and their mechanisms of action at both the molecular and systems levels are discussed. Furthermore, we discuss the crosstalk of these two biological systems and the systems pharmacology approach for understanding the system-wide mechanism of action of CHM on the neuroendocrine-immune network in depression treatment. The holistic, multidrug, and multitarget nature of CHM represents an excellent example of systems medicine in the effective treatment of depression.

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Section: Chm Effects On the Neuroendocrine-immune Networkmentioning

confidence: 99%

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Huang

Zhang

2021

Pharmaceuticals

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“…These results from this study show that TTK attenuated the depressive-like symptoms produced by the astroglial degeneration model of depression. After the glial ablation model of depression was developed [ 18 ], the antidepressant-like effect of mGluR5 antagonist MTEP [ 38 ], prefrontal cortex deep brain stimulation [ 39 ], Y5 receptor antagonist Lu AA33810 [ 40 ], Harmine [ 41 ], ZL006 [ 42 ], and ginsenoside Rf [ 43 ] were tested. In a manner similar to a previous study, infusion of L-AAA induced depressive-like behavior, and administration of imipramine [ 38 ] reversed the depressive behavior and led to a decrease in the number of GFAP-positive cells.…”

Section: Discussionmentioning

confidence: 99%

Tetragonia tetragonioides Relieves Depressive-Like Behavior through the Restoration of Glial Loss in the Prefrontal Cortex

Choi

Kim

Lee

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Tetragonia tetragonioides, which is a halophyte and grows widely in Asian-Pacific regions, has been used for the treatment of digestive disorders in traditional oriental medicine. This study examined the potential antidepressant effect of Tetragonia tetragonioides in an astroglial degeneration model of depression, which was established based on the postmortem study of depressive patients’ brain presenting diminished astrocytes in the prefrontal cortex. C57BL/6 male mice were exposed to glial ablation in the prefrontal cortex by the administration of the gliotoxin, L-alpha-aminoadipic acid (L-AAA) to induce depression. Tetragonia tetragonioides at doses of 100 mg/kg and 300 mg/kg, imipramine at a dose of 15 mg/kg, and distilled water were orally administrated to mice for 18 days. Behavioral tests including the open field test (OFT), sucrose preference test (SPT), forced swimming test (FST), and tail suspension test (TST) were carried out after 2 days of L-AAA injection. The expression levels of GFAP and NeuN in the prefrontal cortex were determined by immunohistochemistry. Mice subjected to glial ablation in the prefrontal cortex displayed decreased sucrose consumption in SPT and increased immobility time in FST and TST. Treatment with imipramine and Tetragonia tetragonioides remarkably ameliorated the behavioral despair induced by L-AAA. In addition, immunohistochemistry analysis showed that treatment with Tetragonia tetragonioides significantly restored the glial loss as indicated by the elevated GFAP expression level. These findings suggest that Tetragonia tetragonioides exerts an antidepressant effect through the restoration of glial loss under conditions of depression and can be a candidate for an antidepressant agent.

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“…Ginsenoside Rf upregulated glial fibrillary acidic protein expression and Ki-67 expression in the PFC, and also alleviated astroglial change in the hippocampus, and therefore reversing depression-like behavior induced by L-alpha-aminoadipic acid (Kim, Lee, Choi, & Cho, 2020).…”

Section: Protecting Astrocytes and Their Gap Junctionsmentioning

confidence: 97%

“…Besides, the L‐alpha‐aminoadipic acid is representative of a major depressive disorder characterized by reduced astrocytes in the brain (Dang et al, 2009; Domin, Szewczyk, Pochwat, Woźniak, & Śmiałowska, 2017; Lee et al, 2013; Takada & Hattori, 1986). Ginsenoside Rf upregulated glial fibrillary acidic protein expression and Ki‐67 expression in the PFC, and also alleviated astroglial change in the hippocampus, and therefore reversing depression‐like behavior induced by L‐alpha‐aminoadipic acid (Kim, Lee, Choi, & Cho, 2020).…”

Section: Pharmacological Actionsmentioning

confidence: 99%

Ginsenosides in central nervous system diseases: Pharmacological actions, mechanisms, and therapeutics

Xian

et al. 2022

Phytotherapy Research

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The nervous system is one of the most complex physiological systems, and central nervous system diseases (CNSDs) are serious diseases that affect human health. Ginseng (Panax L.), the root of Panax species, are famous Chinese herbs that have been used for various diseases in China, Japan, and Korea since ancient times, and remain a popular natural medicine used worldwide in modern times. Ginsenosides are the main active components of ginseng, and increasing evidence has demonstrated that ginsenosides can prevent CNSDs, including neurodegenerative diseases, memory and cognitive impairment, cerebral ischemia injury, depression, brain glioma, multiple sclerosis, which has been confirmed in numerous studies. Therefore, this review summarizes the potential pathways by which ginsenosides affect the pathogenesis of CNSDs mainly including antioxidant effects, anti-inflammatory effects, anti-apoptotic effects, and nerve protection, which provides novel ideas for the treatment of CNSDs.

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Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss

Cited by 19 publications

References 48 publications

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Tetragonia tetragonioides Relieves Depressive-Like Behavior through the Restoration of Glial Loss in the Prefrontal Cortex

Ginsenosides in central nervous system diseases: Pharmacological actions, mechanisms, and therapeutics

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