Antidepressant effects of the extract YZ-50 from<i>Polygala tenuifolia</i>in chronic mild stress treated rats and its possible mechanisms

Hu, Yuan; Liu, Ping; Guo, Dai-Hong; Rahman, Khalid; Wang, Dongxiao; Xie, Tingting

doi:10.3109/13880200903280034

Cited by 34 publications

(30 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polygalae radix extract can protect against N-methyl D-aspartate (NMDA) neurotoxicity [29] and induce the expression of brain-derived neurotrophic factor (BDNF) [30] , which is involved in the modulation of synaptic transmission and plasticity [31] . Activation of TrkB by BDNF results in the phosphorylation of several tyrosine residues and subsequently the stimulation of intracellular signal transduction pathways, such as the MAPK, PI3K and phospholipase C-γ pathways [32] .…”

Section: Discussionmentioning

confidence: 99%

Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice

et al. 2016

View full text Add to dashboard Cite

Aim: Recent studies show that the extract of a Chinese herb Polygalae Radix exerts cognition-enhancing actions in rats and humans. The aim of this study was to characterize the pharmacological profiles of active compounds extracted from Polygalae Radix. Methods: Two fractions P3 and P6 and two compounds PTM-15 and polygalasaponin XXXII (PGS32) were prepared. Neuroprotective effects were evaluated in primary cortical neurons exposed to high concentration glutamate, serum deficiency or H 2 O 2 . Anti-dementia actions were assessed in scopolamine-induced amnesia in mice using step-through avoidance tests and channel water maze tests. After conducting the channel water maze tests, TrkB phosphorylation in mouse hippocampus was detected using Western blotting. Long-term potentiation (LTP) was induced in the dentate gyrus in adult rats; PGS32 (5 μL 400 μmol/L) was injected into the lateral cerebral ventricle 20 min after high frequency stimulation (HFS). Results: Compared to the fraction P6, the fraction P3 showed more prominent neuroprotective effects in vitro and cognitionenhancing effects in scopolamine-induced amnesia in mice. One active compound PGS32 in the fraction P3 exerted potent cognitionenhancing action: oral administration of PGS32 (0.125 mg· kg -1 ·d -1 ) for 19 days abolished scopolamine-induced memory impairment in mice. Furthermore, PGS32 (0.5 and 2 mg· kg -1 ·d -1 ) significantly stimulated the phosphorylation of TrkB in the hippocampus. Intracerebroventricular injection of PGS32 significantly enhanced HFS-induced LTP in the dentate gyrus of rats. Conclusion: PGS32 attenuates scopolamine-induced cognitive impairments in mice, suggesting that it has a potential for the treatment of cognitive dysfunction and dementia.

show abstract

Section: Discussionmentioning

confidence: 99%

Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Within whole hippocampus, CMS consistently reduces BDNF mRNA expression (Nibuya et al, 1999; Song et al, 2006; Mao et al, 2009a, 2010a,b; Hu et al, 2010a,b). However, the reliability of this effect is lost when subregions of the hippocampus are analyzed.…”

Section: Neurochemical Systemsmentioning

confidence: 97%

Neurobiology of chronic mild stress: Parallels to major depression

Hill

Hellemans

Verma

et al. 2012

Neuroscience & Biobehavioral Reviews

369

223

View full text Add to dashboard Cite

The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an animal model of depression more than 20 years ago. The foundation of this model was that following long-term exposure to a series of mild, but unpredictable stressors, animals would develop a state of impaired reward salience that was akin to the anhedonia observed in major depressive disorder. In the time since its inception, this model has also been used for a variety of studies examining neurobiological variables that are associated with depression, despite the fact that this model has never been critically examined to validate that the neurobiological changes induced by CMS are parallel to those documented in depressive disorder. The aim of the current review is to summarize the current state of knowledge regarding the effects of chronic mild stress on neurobiological variables, such as neurochemistry, neurochemical receptor expression and functionality, neurotrophin expression and cellular plasticity. These findings are then compared to those of clinical research examining common variables in populations with depressive disorders to determine if the changes observed following chronic mild stress are in fact consistent with those observed in major depression. We conclude that the chronic mild stress paradigm: (1) evokes an array of neurobiological changes that mirror those seen in depressive disorders and (2) may be a suitable tool to investigate novel systems that could be disturbed in depression, and thus aid in the development of novel targets for the treatment of depression.

show abstract

“…It is a major cause of disability and death by suicide and causes raised rates of physical disorders (Paykel, 2006). The World Health Organization estimated that by 2020 unipolar major depression will become the second largest cause of global disease problems in the world, only behind ischemic heart disease (Hu et al, 2010). Because the mechanism of depression is quite complex, many currently available synthetic chemical antidepressants have low rates of response and remission and even severe adverse effects (Wang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome ofAcorus tatarinowii

Han¹,

Han²,

Peng³

et al. 2013

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Depression is one of the most common psychiatric diseases. Acorus tatarinowii Schott (Araceae) has shown many bioactivities in treatment of senile dementia and epilepsy. However, there is no report on antidepressant-like effects of the essential oil (EO) and its major components on animals under standardized experimental procedures. Objective: This study was designed to investigate the antidepressant properties of EO and asarones from the rhizomes of A. tatarinowii. Materials and methods: Gas chromatography-mass spectrometry (GC/MS) was used to determine the composition of EO. The forced swimming test (FST), tail suspension test (TST) and open-field test (OFT) were used to evaluate the antidepressant-like effects of EO and asarones. EO [30, 60, 120 Results: From the results of GC/MS, it was found that the main components of the EO were a-asarone (9.18%) and b-asarone (68.9%). From the results of FST and TST, the immobility time can be reduced to 166 AE 17 s (p50.01) and 146 AE 15 s (p50.05) by EO at the dose of 120 mg/ kg. Moreover, significant antidepressant-like effects were shown by a-asarone with the immobility time of 178 AE 15 s (p50.05) and 159 AE 17 s (p50.01) in FST, or 147 AE 12 (p50.05) and 134 AE 12 s (p50.01) in TST at the dose of 10 and 20 mg/kg. b-Asarone also displayed antidepressant-like effects with an immobility time of 179 AE 18 s (p50.05) in FST or 142 AE 14 (p50.05) in TST at 20 mg/kg. However, no change in ambulation was observed in the OFT. Conclusion:The results obtained indicate that the EO and asarones from the rhizomes of A. tatarinowii can be considered as a new therapeutic agent for curing depression.

show abstract

Antidepressant effects of the extract YZ-50 fromPolygala tenuifoliain chronic mild stress treated rats and its possible mechanisms

Abstract: (2010) Antidepressant effects of the extract YZ-50 from Polygalatenuifolia in chronic mild stress treated rats and its possible mechanisms, Pharmaceutical Biology, 48:7, 794-800,

Cited by 34 publications

References 33 publications

Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice

Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice

Neurobiology of chronic mild stress: Parallels to major depression

Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome ofAcorus tatarinowii

Contact Info

Product

Resources

About