Antidepressant effects of the methanol extract of several Hypericum species from the Canary Islands

Sánchez-Mateo, Candelaria C.; Prado, B; Rabanal, Rosa M.

doi:10.1016/s0378-8741(01)00393-2

Cited by 56 publications

(47 citation statements)

References 24 publications

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“…However, it is clear from the literature that H. perforatum is the only most characterized species of this genus in terms of phytochemistry and pharmacology. Under the stimulus of great scientific interest and economic value acquired by H. perforatum, studies with other plants of Hypericum genus have also been carried out revealing their antidepressant, analgesic, anti-inflammatory, antioxidant, antimicrobial and wound healing properties (Ö ztürk et al 1996;Apaydin et al 1999;Daudt et al 2000;Mukherjee et al 2001;Trovato et al 2001;Ö ztürk et al 2002;Prado et al 2002;Rabanal et al 2002;Sánchez-Mateo et al 2002;Cakir et al 2003;Couladis et al 2003;Heilmann et al 2003;Rabanal et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Hypericum sp.: essential oil composition and biological activities

2012

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Phytochemical composition of Hypericum genus has been investigated for many years. In the recent past, studies on the essential oils (EO) of this genus have been progressing and many of them have reported interesting biological activities. Variations in the EO composition of Hypericum species influenced by seasonal variation, geographic distribution, phenological cycle and type of the organ in which EO are produced and/or accumulated have also been reported. Although many reviews attributed to the characterization as well as biological activities of H. perforatum crude extracts have been published, no review has been published on the EO composition and biological activities of Hypericum species until recently (Crockett in Nat Prod Commun 5(9): 1493-1506, 2010 Bertoli et al. in Global Sci Books 5:29-47, 2011). In this article, we summarize and update information regarding the composition and biological activities of Hypericum species EO. Based on experimental work carried out in our laboratory we also mention possible biotechnology approaches envisaging EO improvement of some species of the genus.

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Section: Introductionmentioning

confidence: 99%

Hypericum sp.: essential oil composition and biological activities

2012

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“…High fever frequently induces febrile convulsions in children (Lennox-Buchtal,1974;Nelson and Ellenberg,1990) and hyperthermia-induced seizures have been reported in experimental models (Mccaughram and Schetcher,1982;Johnson et al, 1985;Tancredi et al, 1992;Morimoto et al" 1996;Ahlenius et al, 2002). However, hypothermia is known to prevent or reduce nervous damage (Traynelis and Dingledine,1988 ;Maeda et al,1999;Sanchez-Mateo et al, 2002;Takei et al, 2004;Yager et al, 2004). By contrast, the MBMAE acted by inducing convulsive seizures and lowering body temperature.…”

Section: Discussionmentioning

confidence: 99%

Chemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp. montana

Karangwa

Esters

Frédérich

et al. 2006

Journal of Ethnopharmacology

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A4cigni. §/i.pw/cz b4iJciyei. subsp. mon/ancï (CAErysobcz/cïnczceOEe) is known, in the Great Lakes Region, to possess toxicological properties. In this paper, we investigated the acute toxicity (dose levels 50-1600 mgAEg) of its aqueous extract, administered orally to adult Wi. §/c]r rats.This study demonstrated that the freeze-dried aqueous extract (5%, w/w) possesses high toxicity. The extract caused hypothermia, neurological disorders, including extensor reflex of maximal convulsfve induced-seizures at about 2 h after the administered dose, and death occumed (LD5o = 370 mgn{g) in a dose dependent manner.Blood parameter evaluation revealed slight variations, but these might not have clinical relevance. Histological examination of intemal organs (lungs, liver, heart and kidneys) did not reveal any abnormality in the treated group compared to the control. Therefore, it can be concluded that Mcign!.s/!.pw/ci bwfczyc!. subsp. monfczncz aqueous extract, given oral]y, is toxic and that its target is the central nervous system.General phytochemical screening revealed that the plant did not contain significant amounts of products known to be toxic, such as alkaloids or cardioactive glycosides, but only catechic tannins, amino acids, saponins and other aphrogen principles in the three parts of the species (fruit, leave and bark).

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“…All mice were first trained for swimming in a bath with dimensions (42 × 19 × 19 cm) as reported previously (34,35). Mice were placed individually for 6 min in a glass tub filled with water at room temperature (25 ± 2 °C) up to a marked level.…”

Section: Cns Depressant Activitymentioning

confidence: 99%

Neuropharmacological effects of methanolic extracts of Rubus fruticosus L.

Uddin

Hussain²,

Khan³

et al. 2014

Turk J Med Sci

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Leguminous crops suffer severely in soils poor in phosphorus. A 2-factor factorial experiment was conducted in a net-house to explore the effect of graded levels of P fertilizer (0, 30, and 60 kg P ha -1 or P 0 , P 30 , and P 60 , respectively) together with rhizobium (biological nitrogen fertilizer (BNF)) and/or phosphate-solubilizing bacteria (biological phosphorus fertilizer (BPF)) in terms of nutrient uptake, yield, and quality of chickpea (Cicer arietinum L.). Phosphorus was applied as basal dose, while seeds were treated with respective biofertilizer(s) before sowing according to the treatments [BF 0 (control), BNF, BPF, and BNF+BPF]. Concerning the main effects, P 60 proved superior or equivalent to P 30 , while among the biofertilizer treatments, BNF+BPF gave the greatest values for nutrient uptake as well as for yield and quality parameters. The interaction between P levels and biofertilizer treatments was generally significant. 30 kg P ha -1 applied with N and P biofertilizers (P 30 × BNF+BPF) was the most profitable interaction for N uptake as well as for yield and quality characteristics. Compared to P 60 applied alone (P 60 × BF 0 ), P 30 × BNF+BPF resulted in greater N uptake (27.3%), seed yield (21.1%), and the content of seed protein (2.9%) and carbohydrate (5.6%). Furthermore, P 30 × BNF+BPF was statistically equal to P 60 × BNF+BPF with regard to N uptake, seed yield, and protein content as well as for most yield components. Thus, P 30 × BNF+BPF saved 30 kg P ha -1 of the costly inorganic P fertilizer to achieve the greatest crop yield and quality.

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Antidepressant effects of the methanol extract of several Hypericum species from the Canary Islands

Cited by 56 publications

References 24 publications

Hypericum sp.: essential oil composition and biological activities

Hypericum sp.: essential oil composition and biological activities

Chemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp. montana

Neuropharmacological effects of methanolic extracts of Rubus fruticosus L.

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