Antidepressant‐induced sexual dysfunction

Rothmore, Jody

doi:10.5694/mja2.50522

Cited by 132 publications

(88 citation statements)

References 62 publications

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“…However, the exact biological, psychological, and social mechanisms underlying the pathogenesis of depression remain largely unknown. Currently, most patients with depression are treated with synthetic drugs including selective serotonin reuptake inhibitors (SSRI) that act on the monoaminergic system, serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), norepinephrine and dopamine reuptake blockers, and monoamine oxidase inhibitors which exhibit little or no improvement on depression and have side effects such as fatigue, sleep disorders, cognitive disorders, and sexual dysfunctions [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Agomelatine Softens Depressive‐Like Behavior through the Regulation of Autophagy and Apoptosis

Fengpei

Chen

Liu

et al. 2021

BioMed Research International

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Depression is a common and disabling mental disorder with high recurrence rate. Searching for more effective treatments for depression is a long-standing primary objective in neuroscience. Agomelatine (AGO) was reported as an antidepressant with unique pharmacological effects. However, its effects and the underlying mechanism are still unclear. In this study, we sought to evaluate the antidepressant effects of AGO on the chronic restraint stress (CRS) mouse model and preliminarily investigate its effects on the gut microbial metabolites. The CRS model mice were established in 28 days with AGO (60 mg/kg/day, by oral) or fluoxetine (15 mg/kg/day, by oral) administration. The number of behavioral tests was conducted to evaluate the effect of AGO on depression-like behavior alleviation. Meanwhile, the expression of the BDNF/TrkB/pERK signaling pathway, apoptosis, autophagy, and inflammatory protein markers were assessed using western blot and immunofluorescence. Our findings show that AGO can attenuate the depressive-like behavior that significantly appeared in both sucrose preference and forced swimming tests. Additionally, a noticeable upregulation of autophagy including Beclin1 and LC3II, microglial activity marker Iba-1, and BDNF/TrkB/pERK signaling pathways are indicated. An obvious decreased expression of NF-κB, iNOS, and nNOS as well as apoptosis including Bax is observed in AGO administration mice. On the other hand, we found that AGO impacted the rebalancing of short-chain fatty acids (SCFAs) in mouse feces. Altogether, these findings suggest that AGO can exert antidepressant effects in a different molecular mechanism.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Agomelatine Softens Depressive‐Like Behavior through the Regulation of Autophagy and Apoptosis

Fengpei

Chen

Liu

et al. 2021

BioMed Research International

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“…[8][9][10] Indeed, an emerging body of research suggests considering treatment discontinuation for some long-term users. [11][12][13][14] Prolonged use is a concern because of the potential for avoidable side effects and serious adverse events, including upper gastro-intestinal bleeding, hyponatremia, stroke, falls and fractures, [15][16][17] alongside emotional numbing, weight gain, sleep disturbance, sexual dysfunction, 18,19 and loss of personal agency. 20 General practice is the setting in which depression is most commonly treated and antidepressants initiated and maintained.…”

Section: Introductionmentioning

confidence: 99%

Long-term antidepressant use in general practice: a qualitative study of GPs’ views on discontinuation

et al. 2021

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Background: There is considerable concern about increasing antidepressant use, with Australians among the highest users in the world. Evidence suggests this is driven by patients on long-term rather than new prescriptions. Most antidepressant prescriptions are generated in general practice and it is likely that attempts to discontinue are either not occurring or are proving unsuccessful. Aim: To explore GPs’ insights about long-term antidepressant prescribing. Design and Setting: A qualitative interview study with Australian GPs. Method: Semi-structured interviews explored GPs’ discontinuation experiences, decision-making, perceived risks and benefits, and support for patients. Data were analysed using reflexive thematic analysis. Results: Three overarching themes were identified from interviews with 22 GPs. The first, ‘Not a simple deprescribing decision’, speaks to the complex decision-making GPs undertake in determining whether a patient is ready to discontinue. The second, ‘A journey taken together’ captures a set of steps GPs take together with their patients to initiate and set-up adequate support before, during and after discontinuation. The third: ‘Supporting change in GPs’ prescribing practices’ describes what GPs would like to see change to better support them and their patients to discontinue antidepressants. Conclusions: GPs see discontinuation of long-term antidepressant use as more than a simple deprescribing decision. It begins with considering a patients’ social and relational context and is a journey involving careful preparation, tailored care and regular review. These insights suggest interventions to redress long-term use will need to take these considerations into account and be placed in a wider discussion about the use of antidepressants.

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“…Indeed, we recently found that LPS could cause the depressive-like behaviors in mice via activating RagA/mTOR/p70S6K pathway [ 8 ]. As for the therapy of depression, the conventional antidepressant drugs are challenged by gastrointestinal and sexual side effects [ 38 , 39 ]. Interestingly, we recently discovered that botanical drug puerarin could effectively attenuate depression and pain in mice with SNI [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Botanical Drug Puerarin Ameliorates Liposaccharide‐Induced Depressive Behaviors in Mice via Inhibiting RagA/mTOR/p70S6K Pathways

Zhao

Yang

Zhao

et al. 2021

Oxidative Medicine and Cellular Longevity

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Background. The depressive symptom hallmarks the progression of the neurodegenerative diseases, especially Alzheimer’s disease. Bacterial infection is related to inflammation and depression. The present project thereby examined whether botanical drug puerarin could attenuate liposaccharide- (LPS-) induced depressive behaviors in mice. Methods. Adult male C57BL/6N mice were sequentially treated with LPS and puerarin and evaluated for the depressive behaviors by tail suspension test and forced swim test. The brain tissues were profiled for the molecular targets of puerarin by next-generation RNA sequencing technique. Candidate targets were further verified in LPS-treated mice, neural stem cells, and highly differentiated PC12 cell line. Results. Puerarin ameliorated LPS-induced depression in the mice. RNA sequencing profiles revealed that puerarin altered the expression of 16 genes while markedly downregulated Ras-related GTP-binding protein A (RagA) in LPS-treated mice. The effect of puerarin on RagA expression was confirmed by immunostaining, Western blot, and quantitative real-time PCR (qRT-PCR). Biochemical studies showed that puerarin inhibited RagA/mTOR/p70S6K pathway, attenuated the accumulation of mTORC1 in close proximity to lysosome, and reduced the production of proinflammatory cytokines. Conclusions. Botanical drug puerarin attenuated inflammation and depressive behaviors in LPS-challenged mice by inhibiting RagA/mTOR/p70S6K pathways. Puerarin may be a lead compound for the new antidepressant drugs.

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Antidepressant‐induced sexual dysfunction

Cited by 132 publications

References 62 publications

[Retracted] Agomelatine Softens Depressive‐Like Behavior through the Regulation of Autophagy and Apoptosis

[Retracted] Agomelatine Softens Depressive‐Like Behavior through the Regulation of Autophagy and Apoptosis

Long-term antidepressant use in general practice: a qualitative study of GPs’ views on discontinuation

Botanical Drug Puerarin Ameliorates Liposaccharide‐Induced Depressive Behaviors in Mice via Inhibiting RagA/mTOR/p70S6K Pathways

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