Antidepressant-like activity of hyperforin and changes in BDNF and zinc levels in mice exposed to chronic unpredictable mild stress

Szewczyk, Bernadeta; Pochwat, Bartłomiej; Muszyńska, Bożena; Opoka, Włodzimierz; Krakowska, Agata; Rafało-Ulińska, Anna; Friedland, Kristina; Nowak, Gabriel

doi:10.1016/j.bbr.2019.112045

Cited by 41 publications

(31 citation statements)

References 51 publications

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“…Resilience to the Long-Term Effects of RSD on Cocaine CPP Is Associated With Resilience to Depressive-Like Behavior Induced by RSD in the Splash Test Exposure to RSD decreased the duration and frequency of grooming in the splash test, considered a relevant measure of the motivational state of animals (Butelman et al, 2019). A reduction of grooming behavior has been observed after exposure to different stressors (Jolles et al, 1979;Spruijt et al, 1992;Charney, 2004;Smolinsky et al, 2009;Heaney et al, 2011;Veloso et al, 2016;Szewczyk et al, 2019), and has been interpreted as anhedonia, as it is reversed by antidepressant drugs (Brachman et al, 2016;de Souza et al, 2019).…”

Section: Resilience To the Long-term Effects Of Rsd On Cocaine Cpp Ismentioning

confidence: 99%

Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice

Calpe-López

García-Pardo

Martínez-Caballero

et al. 2020

Front. Behav. Neurosci.

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The relationship between stress and drug use is well demonstrated. Stress-induced by repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced by cocaine in mice. The phenomenon of resilience understood as the ability of subjects to overcome the negative effects of stress is the focus of increasing interest. Our aim is to characterize the behavior of resilient animals with respect to the effects of RSD on the CPP induced by cocaine. To this end, 25 male C57BL/6 mice were exposed to stress by RSD during late adolescence, while other 15 male mice did not undergo stress (controls). On the 2 days following the last defeat, all the animals carried out the elevated plus maze (EPM) and Hole Board, Social Interaction, Tail Suspension and Splash tests. Three weeks later, all the animals performed the CPP paradigm with a low dose of cocaine (1 mg/kg). Exposure to RSD decreased all measurements related to the open arms of the EPM. It also reduced social interaction, immobility in the tail suspension test (TST) and grooming in the splash test. RSD exposure also increased the sensitivity of the mice to the rewarding effects of cocaine, since only defeated animals acquired CPP. Several behavioral traits were related to resilience to the potentiating effect of RSD on cocaine CPP. Mice that showed less submission during defeat episodes, a lower percentage of time in the open arms of the EPM, low novelty-seeking, high social interaction, greater immobility in the TST and a higher frequency of grooming were those that were resilient to the long-term effects of social defeat on cocaine reward since they behaved like controls and did not develop CPP. These results suggest that the behavioral profile of resilient defeated mice is characterized by an active coping response during episodes of defeat, a greater concern for potential dangers, less reactivity in a situation of inevitable moderate stress and fewer depressive-like symptoms after stress. Determining the neurobehavioral substrates of resilience is the first step towards developing behavioral or pharmacological interventions that increase resilience in individuals at a high risk of suffering from stress.

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Section: Resilience To the Long-term Effects Of Rsd On Cocaine Cpp Ismentioning

confidence: 99%

Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice

Calpe-López

García-Pardo

Martínez-Caballero

et al. 2020

Front. Behav. Neurosci.

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“…The chronic stress is sudden, compulsive, and long-218 term. A large number of studies have shown that animal models of depression induced by chronic 219 stress are more stable and reliable [21][22][23]. The methods used to establish the stress model vary in 220 different studies.…”

Section: Elisa Resultsmentioning

confidence: 99%

Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1α Pathway

Jia

Tang

Xiao-bin

et al. 2020

IJERPH

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This study was to study the impact of aerobic exercises on the chronic unpredictable mild stress (CUMS) in mice, and to discuss the possible mechanism from the skeletal muscle AMPK/PGC-1α energy metabolism signaling pathway. The healthy male mice were randomly divided into Control Group (CG), Model Group (MG), and Model Exercise Group (ME).Twelve stress methods were adopted for four weeks (28 days) to establish the depression model. ME was subject to aerobic training plan after the model was established. The weight of the mice was recorded weekly. After the experimental intervention, the three groups of mice were subjected to behavioral assessment tests. Western blotting, RT-PCR, and ELISA were performed to test AMPK, p-AMPK, PGC-1α, and ATP in skeletal muscle. There were no significant difference in body weight between the three groups. CUMS leaded to significant decline in behavioral scores. and the p-AMPK and PGC-1α decreased significantly. But boosted ATP content. Aerobic exercise enhanced the expressions of p-AMPK and PGC-1α, increased the ratio of p-AMPK/AMPK, boosted ATP content. And improved behavioral scores significantly. Chronic stress-induced depression-like behavior was improved significantly by Aerobic exercise. The mechanism of aerobic exercise for improving depressive symptoms in mice with chronic stress depression may be related to influence AMPK/PGC-1α pathway.

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“…By testing the OFT entries, distance, and duration in the center, the results showed that CUMS mice expressed significant depression-like behavior compared to the control mice (Figure 7). For EPM, we found that CUMS group mice spent e FST and TST are two of the most commonly used depression models for evaluating antidepression activity in animals [39]. e enhanced immobility time in the FST and TST is suggestive of despair behavior.…”

Section: Discussionmentioning

confidence: 97%

Nelumbo nucifera Gaertn Stems (Hegeng) Improved Depression Behavior in CUMS Mice by Regulating NCAM and GAP‐43 Expression

Cao

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Nelumbo nucifera Gaertn stem (Hegeng [HG]) is a traditional Chinese medicine that is used to treat mental symptoms in East Asia. However, scientific evidence is generally lacking to support this traditional claim. Aim of the Study. This study’s aim is to investigate the antidepression effect of HG and to further explore the possible molecular mechanisms that are involved in its actions. Materials and Methods. HG aqueous extract was administered intragastrically for 21 days after the chronic unpredictable mild stress (CUMS) procedure, and its effect on memory, learning, and emotion was assessed using animal behavioral tests. HG aqueous extract was characterized using HPLC. Immunofluorescence was used to measure the neural cell-adhesion molecule (NCAM) and growth-associated protein-43 (GAP-43) expression. Results. Depression-like behaviors increased in the CUMS group compared with the control (CON) group, while they were reduced in the high-dose HG (H-HG) and fluoxetine (FLU) groups (p<0.05). Additionally, NCAM and GAP-43 expression was reduced in the CUMS group compared with the CON group, but it increased in the H-HG and FLU groups (p<0.05). Conclusions. These findings show the potential antidepressant effects of HG through mechanisms involving regulation of NCAM and GAP-43. This provides a new theoretical basis for its potential application as an antidepressant-like agent.

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Antidepressant-like activity of hyperforin and changes in BDNF and zinc levels in mice exposed to chronic unpredictable mild stress

Cited by 41 publications

References 51 publications

Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice

Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice

Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1α Pathway

Nelumbo nucifera Gaertn Stems (Hegeng) Improved Depression Behavior in CUMS Mice by Regulating NCAM and GAP‐43 Expression

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