Antidepressant-like activity of tramadol in mice

Abstract

Objective:To evaluate antidepressant-like effect of tramadol in mice.Materials and Methods:Tramadol was administered at three different doses (10, 20, and 40 mg/kg, i.p.) once daily for 7 days to Swiss albino mice of either sex. The immobility period of control and drug-treated mice was recorded in forced swim test (FST). The antidepressant effect of tramadol was compared to that of fluoxetine (20 mg/kg, i.p.), administered for seven successive days.Results:Tramadol produced significant antidepressant effect at all the three (10, 20, and 40 mg/kg) doses, as indicated by reduction in immobility times of drug-treated mice compared to control mice. The efficacy of tramadol at doses of 10 and 20 mg/kg was comparable to that of fluoxetine, but antidepressant activity in animals administered with tramadol 40 mg/kg was significantly less as compared to fluoxetine-pretreated mice.Conclusion:The results of the present study indicate antidepressant-like activity of tramadol.

Evaluation of antidepressant activity of tramadol in albino mice using forced swim model

“…in low doses as well as in high doses. 15 But in the present study we found that tramadol was not that much effective in low doses as it was in high doses. They also compared the efficacy of tramadol with fluoxetine like previous study, but we compared the efficacy of tramadol with imipramine.…”

Evaluation of antidepressant activity of tramadol in comparison with imipramine in Swiss albino mice

“…However at higher dosage of 40mg/kg, significant antidepressant activity was seen compared to imipramine. Our finding was concurred by studies of Rojas et al, Kumar A et al and Karla B et al [14][15][16] which evaluated Tramadol using FST model. Tramadol at higher dose inhibits more number of transporters which results in increased reuptake inhibition.…”

Evaluation of antidepressant activity of tramadol in mice: an experimental study

“…On 14 th day the test was performed 30 mins after administration of drugs same as that of single dose study. 8 Open field test [7][8][9][10] This test utilizes behavioral changes in rodents exposed to novel environment and is used to confirm that the observed antidepressant effect is not due to stimulation of general motor activity. Open field apparatus have been used to test the mice.…”