Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa

Abstract

Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test (FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.

Cannabis as a substitute for prescription drugs – a cross-sectional study

“…Chronic pain is an “expensive” condition, both economically and socially, yet existing pharmacotherapeutic interventions are not always adequate 34–36. Taken with preclinical data on the role of the endocannabinoid system in stress, pain processing and immune homeostasis, it is clear that future investigation is warranted using controlled trials with human subjects to better understand the role that cannabis may play in treating pain, anxiety, depression and other conditions 37–46…”

Reflections on the ebola public health emergency of international concern, Part 1: Post-Ebola syndrome: The silent outbreak

“…[34] In addition to these efforts, a call has been made proposing therapeutic trials of cannabidiol, which has been hypothesized to improve inflammatory-mediated symptoms in a number of chronic medical conditions. [3235] In this context, a group of researchers have suggested that Cannabidiol, a phytocannabinoid compound derived from Cannabis sativa ,[32] may offer multiple beneficial properties in humans including anti-inflammatory, anti-anxiety, antinociceptive, and anticonvulsant actions in addition to treating insomnia. [35] However, it has been emphasized that a properly designed and conducted clinical trial must be performed first to determine the efficacy and safety of the proposed cannabidiol treatment.…”

“…[3235] In this context, a group of researchers have suggested that Cannabidiol, a phytocannabinoid compound derived from Cannabis sativa ,[32] may offer multiple beneficial properties in humans including anti-inflammatory, anti-anxiety, antinociceptive, and anticonvulsant actions in addition to treating insomnia. [35] However, it has been emphasized that a properly designed and conducted clinical trial must be performed first to determine the efficacy and safety of the proposed cannabidiol treatment. [32] Finally, the development of a highly effective vaccine against EBOV brings the hope of long-term sustainable containment of this deadly virus.…”

Cannabidiol as a Potential Treatment for Anxiety Disorders

“…CBD has broad therapeutic properties across a range of neuropsychiatric disorders, stemming from diverse central nervous system actions [11,12]. In recent years, CBD has attracted increasing interest as a potential anxiolytic treatment [13][14][15]. The purpose of this review is to assess evidence from current preclinical, clinical, and epidemiological studies pertaining to the potential risks and benefits of CBD as a treatment for anxiety disorders.…”