Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

Basso, Ana M.; Gallagher, Kelly B.; Bratcher, Natalie A; Brioni, Jorge D.; Moreland, Robert B.; Hsieh, Gin C.; Drescher, Karla; Fox, Gerard B.; Decker, Michael; Rueter, Lynne E.

doi:10.1038/sj.npp.1300677

Cited by 73 publications

(37 citation statements)

References 81 publications

(116 reference statements)

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“…Third, few studies have proposed that drugs leading to the enhancement in dopaminergic transmission could act as potential antidepressants in both animal modeling and human clinical practice (Muscat, Towell, & Willner, 1988;Muscat & Willner, 1989;Sampson, Willner, & Muscat, 1991;Kinney, 1985;Basso et al, 2005). Therefore, the precise role of the dopaminergic system and of the different types of dopaminergic receptors is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the precise role of the dopaminergic system and of the different types of dopaminergic receptors is not fully understood. It has been demonstrated that the activation of D2 and D3 receptors could affect the forced swim test (Basso et al, 2005;Siuciak & Fujiwara, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Since its introduction in 1977, the forced swim test (FST) is one of the most widely used animal models for depression (Porsolt et al, 1977;Basso et al, 2005;Connor, Kelliher, Harkin, Kelly, & Leonard, 1999;GutierrezGarcia et al, 2003;Kitamura & Nagatani, 1996;Maj & Rogoz, 1999;Page, Detke, Dalvi, Kirby, & Lucki, 1999;Plaznik, Danysz, & Kostowski, 1985b;Reneric, Bouvard, & Stinus, 2002). It consists of a 40cm diameter cylinder, filled with water until a height of 30cm from the bottom.…”

Section: Introductionmentioning

confidence: 99%

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Contribution of the dopaminergic system to the effect of chronic fluoxetine in the rat forced swim test.

León¹,

Cárdenas²

2008

Psychology & Neuroscience

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Chronic administration of selective serotonin reuptake inhibitors (SSRI) enhances dopaminergic activity. However, the role of enhanced dopaminergic transmission in the therapeutic effects of this kind of antidepressants is still unclear. Drugs producing dopaminergic activation lead to an increment in general activity. Thus, it is reasonable to assume that some of the therapeutic effects of SSRIs are due to dopaminergic enhanced functionality. The forced swim test (FST) is a widely used test in the screening of new compounds with potential antidepressant activity. In this study the effects of pretreatment with low doses of the DA release inductor cocaine and the D2, D3 and D4 antagonist haloperidol were analyzed in the FST on rats submitted to chronic intragastric administration of the SSRI fluoxetine. Our results show that animals treated with fluoxetine and pre-treated with cocaine had significantly higher latencies than saline or haloperidol pre-treated subjects. Among both fluoxetine and saline treated animals, those pre-treated with cocaine had significant lesser immobility time. Haloperidol pre-treated animals had significantly higher immobility time than those pre-treated with saline. From these results, it is clear that the pharmacological modification of dopaminergic systems leads to behavioral changes in rats treated with both saline and fluoxetine. The FST does not have enough precision as to distinguish between dopaminergic and nondopaminergic components in the antidepressant effects of SSRIs, for this reason the use of the FST in combination to other models is mandatory.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Contribution of the dopaminergic system to the effect of chronic fluoxetine in the rat forced swim test.

León¹,

Cárdenas²

2008

Psychology & Neuroscience

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“…The pathophysiology of depression has been classically assigned to the noradrenaline and serotonine systems however, nowadays, published reports also support a role of the dopaminergic system in this disorder [2]. In regard to this, different selective D 2 -type DR agonists were found to display antidepressant-like actions in several rodent models, suggesting a specific role of this receptor subtype in their antidepressant efficacy [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands

Párraga

Cabedo

Andújar

et al. 2013

European Journal of Medicinal Chemistry

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“…[11][12][13][14] Moreover, nomifensine has been used as an antidepressant drug. [15][16][17][18] Clinically, nomifensine is reported to improve depressive mood, declined volition, libido, and fatigue. 19,20) These pharmacological effects involve motivational neurologic function.…”

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confidence: 99%

Motivational Effect of Nomifensine in the Intracranial Self-Stimulation Behavior Using a Runway Method

Sagara

Kitamura

Sendo

et al. 2008

Biological & Pharmaceutical Bulletin

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Intracranial self-stimulation (ICSS) behavior consists of both reward and motivational effects. It is well known that priming stimulation promotes the motivational effects of ICSS behavior.1) The experimental methodology on a runway method using priming stimulation is able to distinguish between the reward and motivational effects of ICSS behavior.2)The operant runway procedure is used successfully to study motivating properties of a wide variety of reinforcing stimuli including food, 3) water, 4) sex 5) i.v. injected heroin, 6,7) amphetamine, 8) nicotine, 9) and cocaine. 10) These reports indicate that the operant running speed reflects the animal's motivation.6-9) However, experimental methodology on the runway method has not yet been successfully implemented to study the motivational effect of reinforcers, including the electrical brain stimulation reward in ICSS.There are very few treatments or therapeutic drugs that have shown to improve motivation in the clinical setting. This is primarily because the methodology to evaluate how drugs influence motivation has not yet been developed in the animal model. In the present study, we examined whether the runway method using priming stimulation on ICSS behavior effective in estimating the motivational effect of several drugs. First, we ascertained whether priming stimulation elevates the motivational effect of receiving reward stimulation by pushing the goal lever. Then, we evaluated running speed and running times, from start box to pushing the goal lever, to use as an indicator of the animal's motivation to seek reward stimulation. Next, we measured the drug's enhancement effect of motivation in the runway method using priming stimulation on ICSS behavior. Finally, we used nomifensine to measure the motivational effect of this experimental design on the runway method. It is well known that nomifensine facilitates ICSS behavior. [11][12][13][14] Moreover, nomifensine has been used as an antidepressant drug. [15][16][17][18] Clinically, nomifensine is reported to improve depressive mood, declined volition, libido, and fatigue.19,20) These pharmacological effects involve motivational neurologic function. Therefore, nomifensine was used as an experimental drug to evaluate the potential increase in motivational effect.In the present study, we evaluated whether the runway method using priming stimulation on ICSS behavior is an effective experimental methodology to measure the drug's motivational effect. It was hypothesized that the delay in the decrease in running speed would reflect the drug's facilitating effect of motivation to obtain the reward stimulation. MATERIALS AND METHODS SubjectsMale Wistar rats (Charles River, Japan), weighing 250-300 g at the time of surgery, were used in this study. Three animals were housed in individual plastic cages (26ϫ36ϫ25 cm) in a room maintained at 22Ϯ2°C with an alternating 12-h light/dark cycle (lights on at 19:00 hours). Food and water were provided ad libitum. The experimental protocol was conducted according to the Guidelin...

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Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

Cited by 73 publications

References 81 publications

Contribution of the dopaminergic system to the effect of chronic fluoxetine in the rat forced swim test.

Contribution of the dopaminergic system to the effect of chronic fluoxetine in the rat forced swim test.

2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands

Motivational Effect of Nomifensine in the Intracranial Self-Stimulation Behavior Using a Runway Method

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